Organic Acids Test (OAT) - Nutritional and Metabolic Profile
UrinePerformed by: Mosaic Diagnostics
Written By: B. Dame
Updated On: January 27, 2025
Discover how the Organic Acids Test (OAT) from MosaicDX provides insights into metabolic health, gut dysbiosis, nutrient deficiencies, and chronic health conditions with 76 biomarkers in a single, easy-to-collect urine test.
What is the Organic Acids Test (OAT)?
The MosaicDX Organic Acids Test (formerly Great Plains Laboratory) is a powerful, non-invasive tool that evaluates 76 organic acids in a single, easy-to-collect urine sample. This test offers unparalleled insight into metabolic health, revealing imbalances in metabolic pathways and identifying nutrient deficiencies that may contribute to chronic health conditions.
The OAT test provides crucial data for individuals with neurological disorders, chronic illnesses, or symptoms like fatigue, anxiety, or digestive issues. By analyzing a wide range of metabolic markers, the OAT helps uncover underlying causes of complex symptoms and guides personalized treatment strategies.
What Does the Organic Acids Test Measure?
The OAT measures over 76 biomarkers through advanced techniques like gas and liquid chromatography coupled with mass spectrometry. These biomarkers fall into several clinically meaningful categories:
-
Intestinal Microbial Overgrowth Markers
- Detects overgrowth of yeast, Clostridia bacteria, and potential mold exposure.
- Assesses imbalances in gut microflora, which can impact immune function and cause behavioral issues, fatigue, and digestive problems.
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Oxalate Metabolites
- Evaluates oxalate levels linked to dietary intake or production by microorganisms.
- High oxalate levels are associated with kidney stones, pain, and inflammation.
-
Glycolytic Cycle and Mitochondrial Markers
- Includes markers from the Krebs Cycle, glycolysis, and amino acid metabolism.
- Identifies mitochondrial dysfunction, which affects energy production and may contribute to fatigue and chronic illnesses.
-
Neurotransmitter Metabolites
- Analyzes key neurotransmitter pathways, such as phenylalanine, tyrosine, and tryptophan metabolism.
- Imbalances may influence mood disorders, anxiety, and depression.
-
Pyrimidine, Ketone, and Fatty Acid Oxidation Markers
- Highlights issues in mitochondrial energy metabolism and fatty acid utilization.
- Assesses folate status and cellular turnover.
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Nutritional Markers
- Measures levels of essential vitamins, antioxidants, and co-factors.
- Detects deficiencies even when standard serum tests appear normal.
-
Detoxification Markers
- Evaluates oxidative stress, glutathione sufficiency, and detoxification pathways, including methylation and transsulfuration.
-
Amino Acid Metabolites
- Identifies potential nutrient needs or genetic metabolic dysfunction based on elevated markers.
-
Mineral Metabolism Markers
- Provides insights into dietary phosphate intake and Vitamin D status.
Why Take the Organic Acids Test?
The OAT is particularly beneficial for individuals experiencing:
- Neurological disorders (e.g., autism, ADHD, Parkinson’s disease)
- Chronic fatigue
- Depression or anxiety
- Fibromyalgia
- Digestive disorders like IBS or gut dysbiosis
- Hormonal imbalances (e.g., insulin resistance, PCOS)
- Unexplained chronic pain
With its ability to detect nutrient deficiencies, mitochondrial dysfunction, and detoxification impairments, the OAT empowers healthcare providers to craft personalized, data-driven treatment plans.
How Organic Acids Reflect Metabolic Health
Organic acids are natural byproducts of protein, carbohydrate, and fat digestion, which play a critical role in energy production and cellular function. However, an abnormal accumulation of organic acids in the urine may signal:
- Inherited enzyme deficiencies
- Nutrient deficiencies (e.g., B vitamins, magnesium)
- Toxic exposure
- Drug effects
Because vitamins and minerals are essential for enzyme function, increased organic acids can indicate a functional nutrient need at the cellular level—even if bloodwork appears normal.
Sample Requirements and Preparation
- Sample Type: First-morning urine collection after an overnight fast.
- Preparation: Avoid certain foods and supplements, such as apples, grapes, pears, cranberries, and ribose, 48 hours before the test.
Why Choose MosaicDX’s Organic Acids Test?
- Non-invasive testing: A simple urine sample provides detailed insights.
- Comprehensive analysis: Evaluates 76 biomarkers to uncover metabolic and nutritional imbalances.
- Actionable results: Helps guide personalized dietary and supplement recommendations for improved health outcomes.
Conditions Addressed by the Organic Acids Test
The OAT can help address a variety of conditions, including:
- Anxiety and mood disorders
- Autism spectrum disorders (ASD)
- Fatigue and chronic pain
- Fibromyalgia and muscle weakness
- Digestive disorders and gut dysbiosis
- Hormonal imbalances, including insulin resistance
- Neurological issues, including Parkinson’s and Alzheimer’s
Frequently Asked Questions (FAQs) About the Organic Acids Test (OAT)
1. What is the Organic Acids Test (OAT)?
The Organic Acids Test (OAT) is a comprehensive urine test that evaluates 76 metabolic markers to assess your body’s metabolic health, nutrient status, and gut microbiome. It provides insights into energy production, detoxification, neurotransmitter balance, and more.
2. Who should take the Organic Acids Test?
The OAT is ideal for individuals experiencing:
- Chronic fatigue or fibromyalgia
- Anxiety, depression, or other mood disorders
- Digestive issues, such as bloating or IBS
- Neurological disorders like ADHD, autism, or Parkinson’s disease
- Hormonal imbalances, including insulin resistance or PCOS
- Unexplained pain or inflammation
3. What does the Organic Acids Test measure?
The OAT measures a wide range of markers, including:
- Gut microbial overgrowth (yeast, bacteria, and mold toxins)
- Oxalate levels (linked to kidney stones and inflammation)
- Mitochondrial function (energy production)
- Neurotransmitter metabolites (dopamine, serotonin, etc.)
- Detoxification markers (glutathione and oxidative stress)
- Nutritional markers (vitamins, antioxidants, and co-factors)
4. How is the Organic Acids Test performed?
The test requires a first-morning urine sample collected after fasting overnight. Certain foods and supplements, such as apples, grapes, cranberries, ribose, and echinacea, should be avoided 48 hours before collection.
5. How does the OAT detect gut microbial overgrowth?
The test identifies specific organic acids produced by yeast, bacteria, or molds in the gut. Elevated levels of these markers can signal microbial overgrowth or dysbiosis, which may cause digestive issues, fatigue, or immune dysfunction.
6. Can the Organic Acids Test detect nutrient deficiencies?
Yes. The OAT reveals nutrient deficiencies by identifying elevated levels of specific organic acids that indicate a functional need for vitamins or minerals, such as B vitamins, magnesium, or antioxidants.
7. Is the Organic Acids Test suitable for children?
Yes, the OAT is safe for children and can be particularly helpful in identifying metabolic imbalances or gut microbial issues in children with developmental or behavioral conditions, such as autism spectrum disorder (ASD).
8. How long does it take to get results from the OAT?
Results are typically available within 1-2 weeks after the lab receives the urine sample. A detailed report categorizes findings into actionable sections for healthcare providers.
9. What are the benefits of the Organic Acids Test over traditional tests?
The OAT provides functional insights that traditional blood tests may not detect. It evaluates how well your body’s metabolic pathways are working, uncovering nutrient needs, detoxification issues, and mitochondrial dysfunction even when serum levels appear normal.
10. What conditions can the OAT help address?
The Organic Acids Test can provide insights for managing:
- Fatigue and low energy
- Depression, anxiety, and mood disorders
- Digestive imbalances, such as gut dysbiosis
- Neurological disorders (ADHD, autism, Parkinson’s, etc.)
- Fibromyalgia and chronic pain
- Oxalate-related conditions (e.g., kidney stones)
11. Can the results of the Organic Acids Test guide treatment?
Yes, the results can guide your healthcare provider in creating a personalized treatment plan, including recommendations for dietary changes, targeted nutrient supplementation, and strategies to address underlying imbalances.
12. Are there any limitations to the Organic Acids Test?
While the OAT is highly comprehensive, its findings are best interpreted alongside clinical symptoms and under the guidance of a qualified healthcare provider. The test does not diagnose specific diseases but identifies metabolic imbalances that may contribute to symptoms.
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Biomarkers included in this panel:
What is 2-Hydroxybutyric acid? 2-Hydroxybutyric acid (aka α-Hydroxybutyrate) is a by-product of glutathione production. Levels of 2-Hydroxybutyric acid in the urine may reflect levels of glutathione production. What is Glutathione? Glu
Learn moreWhat is 2-Hydroxybutyric acid? 2-Hydroxybutyric acid (aka α-Hydroxybutyrate) is a by-product of glutathione production. Levels of 2-Hydroxybutyric acid in the urine may reflect levels of glutathione production. What is Glutathione? Glu
Learn moreWhat is 2-Hydroxybutyric acid? 2-Hydroxybutyric acid (aka α-Hydroxybutyrate) is a by-product of glutathione production. Levels of 2-Hydroxybutyric acid in the urine may reflect levels of glutathione production. What is Glutathione? Glu
Learn more2-Hydroxyhippuric acid is a conjugate of hydroxybenzoic acid (salicylic acid) and glycine.
Learn more2-Hydroxyhippuric acid is a conjugate of hydroxybenzoic acid (salicylic acid) and glycine.
Learn more2-Hydroxyhippuric acid is a conjugate of hydroxybenzoic acid (salicylic acid) and glycine.
Learn more2-Hydroxyhippuric acid is a conjugate of hydroxybenzoic acid (salicylic acid) and glycine.
Learn more2-Hydroxyisocaproic acid (aka Leucic acid / α-hydroxyisocaproic acid / HICA) is a metabolite of the branched-chain amino acid leucine.
Learn more2-Hydroxyisocaproic acid (aka Leucic acid / α-hydroxyisocaproic acid / HICA) is a metabolite of the branched-chain amino acid leucine.
Learn more2-Hydroxyisovaleric acid (aka 2-Hydroxy-3-methylbutyric acid) is a branched-chain amino acid metabolite.
Learn more2-Hydroxyisovaleric acid (aka 2-Hydroxy-3-methylbutyric acid) is a branched-chain amino acid metabolite.
Learn more2-Hydroxyisovaleric acid (aka 2-Hydroxy-3-methylbutyric acid) is a branched-chain amino acid metabolite.
Learn moreThe metabolite of phenylalanine via phenyl pyruvate.
Learn moreThe metabolite of phenylalanine via phenyl pyruvate.
Learn moreThe metabolite of phenylalanine via phenyl pyruvate.
Learn more2-Oxo-4-methylthiobutanoic acid, also known as 4-(methylsulfanyl)-2-oxobutanoate or 2-keto-4-methylthiobutyrate, belongs to the class of organic compounds known as thia fatty acids. Thia substituted fatty acids are saturated
Learn more2-Oxo-4-methylthiobutanoic acid, also known as 4-(methylsulfanyl)-2-oxobutanoate or 2-keto-4-methylthiobutyrate, belongs to the class of organic compounds known as thia fatty acids. Thia substituted fatty acids are saturated
Learn more2-Oxoglutaric acid is an organic acid that is important for the proper metabolism of all essential amino acids. It is formed in the Krebs cycle, the energy-producing process that occurs in most body cells.
Learn more2-Oxoglutaric acid is an organic acid that is important for the proper metabolism of all essential amino acids. It is formed in the Krebs cycle, the energy-producing process that occurs in most body cells.
Learn more2-Oxoisocaproic acid (also known as Ketoleucine) is an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids. 2-Oxoisocaproic acid is both a neurotoxin and a metabotoxin.
Learn more2-Oxoisocaproic acid (also known as Ketoleucine) is an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids. 2-Oxoisocaproic acid is both a neurotoxin and a metabotoxin.
Learn more2-Oxoisovaleric acid is an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids (=BCAA). 2-Oxoisovaleric acid is a neurotoxin, an acidogen, and a metabotoxin.
Learn more2-Oxoisovaleric acid is an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids (=BCAA). 2-Oxoisovaleric acid is a neurotoxin, an acidogen, and a metabotoxin.
Learn more- A precursor in the production of cholesterol in both humans and yeast. - Elevated levels may also indicate decreased CoQ10 synthesis. - Moderate increases are probably due to yeast overgrowth of the GI tract and might also implicate yeast ove
Learn more- A precursor in the production of cholesterol in both humans and yeast. - Elevated levels may also indicate decreased CoQ10 synthesis. - Moderate increases are probably due to yeast overgrowth of the GI tract and might also implicate yeast ove
Learn more3-Hydroxybutyric acid is a typical partial-degradation product of branched-chain amino acids (primarily valine) released from muscle for hepatic and renal gluconeogenesis. This acid is metabolized by 3-hydroxybutyrate dehydrogenase. The enzyme f
Learn more3-Hydroxybutyric acid is a typical partial-degradation product of branched-chain amino acids (primarily valine) released from muscle for hepatic and renal gluconeogenesis. This acid is metabolized by 3-hydroxybutyrate dehydrogenase. The enzyme f
Learn more3-Hydroxybutyric acid is a typical partial-degradation product of branched-chain amino acids (primarily valine) released from muscle for hepatic and renal gluconeogenesis. This acid is metabolized by 3-hydroxybutyrate dehydrogenase. The enzyme f
Learn more3-Hydroxyglutaric is a marker for glutaryl CoA dehydrogenase deficiency.
Learn more3-Hydroxyglutaric is a marker for glutaryl CoA dehydrogenase deficiency.
Learn more3-Indoleacetic is a Tryptophan byproduct of Clostria: C. stricklandii, C. litusburense, C. subterminale, and C. putrefaciens.
Learn more3-Indoleacetic is a Tryptophan byproduct of Clostria: C. stricklandii, C. litusburense, C. subterminale, and C. putrefaciens.
Learn more3-Methyl-2-oxovaleric acid is an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids. Moderate increase may result from lactic acidosis, episodic ketosis, or thiamine/lipoic acid deficiency. Significan
Learn more3-Methyl-2-oxovaleric acid is an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids. Moderate increase may result from lactic acidosis, episodic ketosis, or thiamine/lipoic acid deficiency. Significan
Learn more3-Methyl-2-oxovaleric acid is an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids. Moderate increase may result from lactic acidosis, episodic ketosis, or thiamine/lipoic acid deficiency. Significan
Learn moreThe marker, 3-methylglutaconic acid in high values indicates a reduced ability to metabolize the amino acid, leucine. This abnormality is found in the genetic disease, methylglutaconic aciduria and in mitochondrial disorders.
Learn moreThe marker, 3-methylglutaconic acid in high values indicates a reduced ability to metabolize the amino acid, leucine. This abnormality is found in the genetic disease, methylglutaconic aciduria and in mitochondrial disorders.
Learn more3-methylglutaric acid is an organic acid classically associated with two distinct leucine pathway enzyme deficiencies.
Learn more3-methylglutaric acid is an organic acid classically associated with two distinct leucine pathway enzyme deficiencies.
Learn more3-methylglutaric acid is an organic acid classically associated with two distinct leucine pathway enzyme deficiencies.
Learn more3-methylglutaric acid is an organic acid classically associated with two distinct leucine pathway enzyme deficiencies.
Learn more3-Oxoglutaric indicates yeast overgrowth in the gastrointestinal tract.
Learn more3-Oxoglutaric indicates yeast overgrowth in the gastrointestinal tract.
Learn more3-Oxoglutaric indicates yeast overgrowth in the gastrointestinal tract.
Learn more4-Cresol has been used as a specific marker for Clostridium difficile.
Learn more4-Cresol has been used as a specific marker for Clostridium difficile.
Learn more4-Hydroxybenzoic Acid is a marker for intestinal dysbiosis.
Learn more4-Hydroxybenzoic Acid is a marker for intestinal dysbiosis.
Learn more4-Hydroxybenzoic Acid is a marker for intestinal dysbiosis.
Learn moreA moderate urinary increase in 4-hydroxybutyric acid may be due to intake of dietary supplements containing 4-hydroxybutyric acid, also known as gamma-hydroxybutyric acid. Very high levels may indicate the genetic disorder 3-methylglutaconic aciduria
Learn moreA moderate urinary increase in 4-hydroxybutyric acid may be due to intake of dietary supplements containing 4-hydroxybutyric acid, also known as gamma-hydroxybutyric acid. Very high levels may indicate the genetic disorder 3-methylglutaconic aciduria
Learn moreA moderate urinary increase in 4-hydroxybutyric acid may be due to intake of dietary supplements containing 4-hydroxybutyric acid, also known as gamma-hydroxybutyric acid. Very high levels may indicate the genetic disorder 3-methylglutaconic aciduria
Learn moreA moderate urinary increase in 4-hydroxybutyric acid may be due to intake of dietary supplements containing 4-hydroxybutyric acid, also known as gamma-hydroxybutyric acid. Very high levels may indicate the genetic disorder 3-methylglutaconic aciduria
Learn more4-Hydroxyhippuric is a glycine conjugate of 4-hydroxybenzoic acid, the paraben metabolite.
Learn more4-Hydroxyhippuric is a glycine conjugate of 4-hydroxybenzoic acid, the paraben metabolite.
Learn more4-Hydroxyhippuric is a glycine conjugate of 4-hydroxybenzoic acid, the paraben metabolite.
Learn moreA tyrosine metabolic product of GI bacteria.
Learn moreA tyrosine metabolic product of GI bacteria.
Learn moreA tyrosine metabolic product of GI bacteria.
Learn moreA tyrosine metabolic product of GI bacteria.
Learn more4-hydroxyphenyllactate is present in relatively higher concentrations in the cerebrospinal fluid and urine of patients with phenylketonuria (PKU) and tyrosinemia.
Learn more4-hydroxyphenyllactate is present in relatively higher concentrations in the cerebrospinal fluid and urine of patients with phenylketonuria (PKU) and tyrosinemia.
Learn more5-Hydroxyindoleacetic acid (5HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin is a hormone found at high levels in many body tissues. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels
Learn more5-Hydroxyindoleacetic acid (5HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin is a hormone found at high levels in many body tissues. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels
Learn moreA metabolite produced by Aspergillus and possibly other fungal species in the GI tract.
Learn moreA metabolite produced by Aspergillus and possibly other fungal species in the GI tract.
Learn moreA metabolite produced by Aspergillus and possibly other fungal species in the GI tract. Prescription or natural antifungals, along with high-potency, multi-strain probiotics, may reduce overgrowth levels.
Learn moreAcetoacetic acid (=acetoacetate) is a ketone body and a weak Beta-keto acid produced from acetyl-CoA in the mitochondrial matrix of hepatocytes.
Learn moreAcetoacetic acid (=acetoacetate) is a ketone body and a weak Beta-keto acid produced from acetyl-CoA in the mitochondrial matrix of hepatocytes.
Learn moreAcetoacetic acid (=acetoacetate) is a ketone body and a weak Beta-keto acid produced from acetyl-CoA in the mitochondrial matrix of hepatocytes.
Learn moreElevated in mitochrondrial disorders. Aconitase metabolizes citric and aconitic acids, and is dependent on glutathione.
Learn moreElevated in mitochrondrial disorders. Aconitase metabolizes citric and aconitic acids, and is dependent on glutathione.
Learn moreElevated in mitochrondrial disorders. Aconitase metabolizes citric and aconitic acids, and is dependent on glutathione.
Learn moreAdipic Acid, together with Suberate and Ethylmalonate are all functional markers for deficiency of carnitine.
Learn moreAdipic Acid, together with Suberate and Ethylmalonate are all functional markers for deficiency of carnitine.
Learn moreAdipic Acid, together with Suberate and Ethylmalonate are all functional markers for deficiency of carnitine.
Learn moreBreakdown product of hyaluronic acid; also found in certain foods.
Learn moreProduced by action of Candida hyaluronidase on the intercellular cement, hyaluronic acid. Oxidation of the hyaluronic acid breakdown by white blood cell hypochlorite produces tartaric acid and arabinose. Antifungal treatment and high-potency, multi-s
Learn moreBreakdown product of hyaluronic acid; also found in certain foods.
Learn moreProduced by action of Candida hyaluronidase on the intercellular cement, hyaluronic acid. Oxidation of the hyaluronic acid breakdown by white blood cell hypochlorite produces tartaric acid and arabinose. Antifungal treatment and high-potency, multi-s
Learn moreAscorbic Acid is a natural water-soluble vitamin (Vitamin C). Ascorbic acid is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen in fibro
Learn moreAscorbic Acid is a natural water-soluble vitamin (Vitamin C). Ascorbic acid is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen in fibro
Learn moreAscorbic Acid is a natural water-soluble vitamin (Vitamin C). Ascorbic acid is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen in fibro
Learn moreCarboxycitric is a metabolite of yeast/fungi and general indicator of gastrointestinal dysbiosis. Elevated yeast/fungal metabolites indicate overgrowth in the GI tract.
Learn moreCarboxycitric is a metabolite of yeast/fungi and general indicator of gastrointestinal dysbiosis. Elevated yeast/fungal metabolites indicate overgrowth in the GI tract.
Learn moreMetabolite of yeast or anaerobic bacteria, including Clostridia.
Learn moreMetabolite of yeast or anaerobic bacteria, including Clostridia.
Learn moreCitric acid, cis-aconitic acid, and isocitric acid are the first three metabolites in the Krebs Citric Acid energy production cycle, which operates in the mitochondria of your cells.
Learn moreCitric acid, cis-aconitic acid, and isocitric acid are the first three metabolites in the Krebs Citric Acid energy production cycle, which operates in the mitochondria of your cells.
Learn moreCitric acid, cis-aconitic acid, and isocitric acid are the first three metabolites in the Krebs Citric Acid energy production cycle, which operates in the mitochondria of your cells.
Learn moreProduced when Clostridia acts upon unabsorbed tryptophan, tyrosine or phenylalanine.
Learn moreProduced when Clostridia acts upon unabsorbed tryptophan, tyrosine or phenylalanine.
Learn moreProduced when Clostridia acts upon unabsorbed tryptophan, tyrosine or phenylalanine.
Learn moreHVA and DOPAC are the major metabolites of dopamine.
Learn moreHVA and DOPAC are the major metabolites of dopamine.
Learn moreHVA and DOPAC are the major metabolites of dopamine.
Learn moreHVA and DOPAC are the major metabolites of dopamine.
Learn moreEthylmalonate, together with Adipate and Suberate, gives information about your ability to process fatty acids.
Learn moreFumaric acid, measured on the Organic Acids Test (OAT), is a key marker of your body’s energy production and detoxification pathways. It plays a vital role in the Citric Acid Cycle, which generates cellular energy, and the urea cycle, which eli
Learn moreFumarate (together with Succinate and Malate) is used in the body’s metabolic pathway that generates cellular energy – the Citric Acid Cycle.
Learn moreFumarate (together with Succinate and Malate) is used in the body’s metabolic pathway that generates cellular energy – the Citric Acid Cycle.
Learn moreFuran 2,5-dicarboxylic is a byproduct of Aspergillus and other fungal species.
Learn moreFuran 2,5-dicarboxylic is a byproduct of Aspergillus and other fungal species.
Learn moreFurancarbonylglycine is a metabolite produced by Aspergillus and possibly other fungal species in the GI tract.
Learn moreA metabolite produced by Aspergillus and possibly other fungal species in the GI tract. Prescription or natural antifungals, along with high-potency, multi-strain probiotics, may reduce overgrowth.
Learn moreFurancarbonylglycine is a metabolite produced by Aspergillus and possibly other fungal species in the GI tract.
Learn moreA metabolite produced by Aspergillus and possibly other fungal species in the GI tract. Prescription or natural antifungals, along with high-potency, multi-strain probiotics, may reduce overgrowth.
Learn moreGlutaric acid is made from lysine & tryptophan via alphaketo-adipic acid. - Elevated in the genetic diseases glutaric academia types I and II. - Moderate increases may be due to deficiencies in riboflavin and coenzyme Q10, or celiac disease.
Learn moreGlutaric acid is made from lysine & tryptophan via alphaketo-adipic acid. - Elevated in the genetic diseases glutaric academia types I and II. - Moderate increases may be due to deficiencies in riboflavin and coenzyme Q10, or celiac disease.
Learn moreGlutaric acid is made from lysine & tryptophan via alphaketo-adipic acid. - Elevated in the genetic diseases glutaric academia types I and II. - Moderate increases may be due to deficiencies in riboflavin and coenzyme Q10, or celiac disease.
Learn moreGlutaric acid is made from lysine & tryptophan via alphaketo-adipic acid. - Elevated in the genetic diseases glutaric academia types I and II. - Moderate increases may be due to deficiencies in riboflavin and coenzyme Q10, or celiac disease.
Learn moreThe organic acids test by Great Plains Laboratory measures a few oxalate metabolites which can determine if someone has high oxalate levels. These include oxalic, glycolic, and glyceric. In humans and in yeast, glyoxalate is the parent compound th
Learn moreNormal values rule out genetic causes of significantly elevated urinary oxalic acid.
Learn moreNormal values rule out genetic causes of significantly elevated urinary oxalic acid.
Learn moreIndicator of genetic disease of oxalate metabolism called Hyperoxaluria type I due to a deficiency in the enzyme activity of alanine glyoxylate amino transferase (AGT).
Learn moreIndicator of genetic disease of oxalate metabolism called Hyperoxaluria type I due to a deficiency in the enzyme activity of alanine glyoxylate amino transferase (AGT).
Learn moreHippuric acid is a conjugate (=a compound formed by the joining of two or more compounds) of glycine and benzoic acid formed in the liver. Most hippuric acid in urine is derived from microbial breakdown of chlorogenic acid to benzoic aci
Learn moreHippuric acid is a conjugate (=a compound formed by the joining of two or more compounds) of glycine and benzoic acid formed in the liver. Most hippuric acid in urine is derived from microbial breakdown of chlorogenic acid to benzoic aci
Learn moreHippuric acid is a conjugate (=a compound formed by the joining of two or more compounds) of glycine and benzoic acid formed in the liver. Most hippuric acid in urine is derived from microbial breakdown of chlorogenic acid to benzoic aci
Learn moreHomogentisic acid is a breakdown product of 4-Hydroxyphenylpyruvic Acid (4-HPPA). Elevated in the genetic disease homogentisic aciduria (alkaptonuria).
Learn moreHomogentisic acid is a breakdown product of 4-Hydroxyphenylpyruvic Acid (4-HPPA). Elevated in the genetic disease homogentisic aciduria (alkaptonuria).
Learn moreHomovanillate (aka Homovanillic Acid) is a dopamine metabolite. Homovanillate and Vanilmandelate are breakdown products from neurotransmitters involved in hormone and nerve impulse transmission, called catecholamines.
Learn moreHomovanillate (aka Homovanillic Acid) is a dopamine metabolite. Homovanillate and Vanilmandelate are breakdown products from neurotransmitters involved in hormone and nerve impulse transmission, called catecholamines.
Learn moreHPHPA is a clostridia metabolite and dysbiosis marker and stands for 3-(3-hydroxyphenyl)-3-hydroxypropionic acid.
Learn moreHPHPA is a clostridia metabolite and dysbiosis marker and stands for 3-(3-hydroxyphenyl)-3-hydroxypropionic acid.
Learn moreHPHPA is a clostridia metabolite and dysbiosis marker and stands for 3-(3-hydroxyphenyl)-3-hydroxypropionic acid.
Learn moreThe Organic Acids Test measures levels of HVA (homovanillic acid) and VMA (vanillylmandelic acid), the metabolites of the neurotransmitters, dopamine and epinephrine/norepinephrine. It also measures the ratio of the two metabolites.
Learn moreThe Organic Acids Test measures levels of HVA (homovanillic acid) and VMA (vanillylmandelic acid), the metabolites of the neurotransmitters, dopamine and epinephrine/norepinephrine. It also measures the ratio of the two metabolites.
Learn moreThe Organic Acids Test measures levels of HVA (homovanillic acid) and VMA (vanillylmandelic acid), the metabolites of the neurotransmitters, dopamine and epinephrine/norepinephrine. It also measures the ratio of the two metabolites.
Learn moreHVA and DOPAC are the major metabolites of dopamine. HVA stands for Homovanillic acid and DOPAC stands for Dihydroxyphenylacetic.
Learn moreHVA and DOPAC are the major metabolites of dopamine. HVA stands for Homovanillic acid and DOPAC stands for Dihydroxyphenylacetic.
Learn moreKynurenic Acid is product of the metabolism of L-Tryptophan and appears in urine in Vitamin B6 deficiencies. Your body needs vitamin B6 (pyridoxine) to utilize amino acids derived from dietary protein.
Learn moreKynurenic Acid is product of the metabolism of L-Tryptophan and appears in urine in Vitamin B6 deficiencies. Your body needs vitamin B6 (pyridoxine) to utilize amino acids derived from dietary protein.
Learn moreFormed from pyruvate in anaerobic or oxygen-starved (hypoxic) conditions to allow for ongoing production of ATP.
Learn moreFormed from pyruvate in anaerobic or oxygen-starved (hypoxic) conditions to allow for ongoing production of ATP.
Learn moreFormed from pyruvate in anaerobic or oxygen-starved (hypoxic) conditions to allow for ongoing production of ATP.
Learn moreMalic Acid is involved in the citric acid cycle (aka. Krebs cycle). The citric acid cycle is a series of reactions that occur in the mitochondrion to generate chemical energy that fuels the metabolism.
Learn moreMalic Acid is involved in the citric acid cycle (aka. Krebs cycle). The citric acid cycle is a series of reactions that occur in the mitochondrion to generate chemical energy that fuels the metabolism.
Learn moreMalic Acid is involved in the citric acid cycle (aka. Krebs cycle). The citric acid cycle is a series of reactions that occur in the mitochondrion to generate chemical energy that fuels the metabolism.
Learn moreMalonic acid is found to be associated with malonyl-CoA decarboxylase deficiency, which is an inborn error of metabolism. The name “Malonic” originates from Latin malum, meaning apple. Malonic acid is the archetypal example of a competiti
Learn moreMalonic acid is found to be associated with malonyl-CoA decarboxylase deficiency, which is an inborn error of metabolism. The name “Malonic” originates from Latin malum, meaning apple. Malonic acid is the archetypal example of a competiti
Learn moreMandelic acid is the major metabolite of styrene. Styrene (vinylbenzene) is used as an intermediate in plastic synthesis. Values less than 5 mg/L are due to normal metabolism of phenylalanine or tyrosine.
Learn moreMandelic acid is the major metabolite of styrene. Styrene (vinylbenzene) is used as an intermediate in plastic synthesis. Values less than 5 mg/L are due to normal metabolism of phenylalanine or tyrosine.
Learn moreMethylcitric is an organic acids that reflects decreased activity of the biotin-dependent enzyme propionyl-CoA carboxylase.
Learn moreMethylcitric is an organic acids that reflects decreased activity of the biotin-dependent enzyme propionyl-CoA carboxylase.
Learn moreMethylmalonic acid (MMA) is a substance produced in very small amounts and is necessary for human metabolism and energy production.
Learn moreMethylmalonic acid (MMA) is a substance produced in very small amounts and is necessary for human metabolism and energy production.
Learn moreMethylsuccinic acid is a normal metabolite found in human fluids and is an intermediate metabolite in the breakdown of fatty acids.
Learn moreMethylsuccinic acid is a normal metabolite found in human fluids and is an intermediate metabolite in the breakdown of fatty acids.
Learn moreMethylsuccinic acid is a normal metabolite found in human fluids and is an intermediate metabolite in the breakdown of fatty acids.
Learn moreElevated N-acetylaspartic acid is due to the genetic disorder Carnavan’s disease, a potentially fatal disease causing spongy degeneration of the brain. What is Carnavan’s disease? Canavan disease is a rare inherited disorder t
Learn moreElevated N-acetylaspartic acid is due to the genetic disorder Carnavan’s disease, a potentially fatal disease causing spongy degeneration of the brain. What is Carnavan’s disease? Canavan disease is a rare inherited disorder t
Learn moreN-Acetylcysteine (NAC) is a powerful antioxidant that increases the glutathione reserves in the body. Together with glutathione, N-Acetylcysteine (NAC) directly binds to toxic metabolites. Although N-Acetylcysteine (NAC) may be benefici
Learn moreN-Acetylcysteine (NAC) is a powerful antioxidant that increases the glutathione reserves in the body. Together with glutathione, N-Acetylcysteine (NAC) directly binds to toxic metabolites. Although N-Acetylcysteine (NAC) may be benefici
Learn moreOrotic Acid is a sensitive marker of your liver’s capacity to convert toxic ammonia to non-toxic urea that you can excrete. That capacity can be increased by additional arginine. Ammonia toxicity can also be reduced by
Learn moreOrotic Acid is a sensitive marker of your liver’s capacity to convert toxic ammonia to non-toxic urea that you can excrete. That capacity can be increased by additional arginine. Ammonia toxicity can also be reduced by
Learn moreOrotic Acid is a sensitive marker of your liver’s capacity to convert toxic ammonia to non-toxic urea that you can excrete. That capacity can be increased by additional arginine. Ammonia toxicity can also be reduced by
Learn moreOxalic acid may be associated with dysbiosis from Aspergillus, Penicillium, Candida, or high dose vitamin C. If yeast or fungal markers are elevated, antifungal therapy may reduces oxalates. Also associated with anti-freeze (ethylene glycol) poisonin
Learn moreOxalic acid may be associated with dysbiosis from Aspergillus, Penicillium, Candida, or high dose vitamin C. If yeast or fungal markers are elevated, antifungal therapy may reduces oxalates. Also associated with anti-freeze (ethylene glycol) poisonin
Learn moreOxalic acid may be associated with dysbiosis from Aspergillus, Penicillium, Candida, or high dose vitamin C. If yeast or fungal markers are elevated, antifungal therapy may reduces oxalates. Also associated with anti-freeze (ethylene glycol) poisonin
Learn moreOxalic acid may be associated with dysbiosis from Aspergillus, Penicillium, Candida, or high dose vitamin C. If yeast or fungal markers are elevated, antifungal therapy may reduces oxalates. Also associated with anti-freeze (ethylene glycol) poisonin
Learn morePantothenic acid is an essential B vitamin (=Vitamin B5) that is converted to coenzyme A (unrelated to vitamin A). Coenzyme A is needed for the synthesis of fatty acids, cholesterol, and acetyl choline and is also needed for the Krebs cycle and fatty
Learn morePantothenic acid is an essential B vitamin (=Vitamin B5) that is converted to coenzyme A (unrelated to vitamin A). Coenzyme A is needed for the synthesis of fatty acids, cholesterol, and acetyl choline and is also needed for the Krebs cycle and fatty
Learn morePantothenic acid is an essential B vitamin (=Vitamin B5) that is converted to coenzyme A (unrelated to vitamin A). Coenzyme A is needed for the synthesis of fatty acids, cholesterol, and acetyl choline and is also needed for the Krebs cycle and fatty
Learn morePhenyllactic acid is a metabolite of phenylalanine.
Learn morePhenyllactic acid is a metabolite of phenylalanine.
Learn morePhenylpyruvic acid is a keto-acid that is an intermediate or catabolic byproduct of phenylalanine metabolism. It has a slight honey-like odor.
Learn morePhenylpyruvic acid is a keto-acid that is an intermediate or catabolic byproduct of phenylalanine metabolism. It has a slight honey-like odor.
Learn morePhosphoric acid is a marker of vitamin D and calcium. This marker indicates whether vitamin D receptors are activated. If phosphoric acid is low, then the person is likely vitamin D and/or calcium deficient. Low levels can be due to low phosphat
Learn morePhosphoric acid is a marker of vitamin D and calcium. This marker indicates whether vitamin D receptors are activated. If phosphoric acid is low, then the person is likely vitamin D and/or calcium deficient. Low levels can be due to low phosphat
Learn moreA major metabolite of vitamin B6. High pyridoxic acid indicates high recent intake of vitamin B6. Because some individuals may require very high doses of vitamin B6, high values do not necessarily indicate the need to reduce vitamin B6 intake. Low va
Learn moreThe main urinary metabolite of pyridoxine (Vitamin B6) and is a measure of recent dietary intake. Low values of pyridoxic acid in the urine indicate low recent intake while high values indicate high recent dietary intake.
Learn morePyroglutamate (or Pyroglutamic acid) is an intermediate in the glutathione metabolism and a marker of glutathione deficiency.
Learn morePyroglutamate (or Pyroglutamic acid) is an intermediate in the glutathione metabolism and a marker of glutathione deficiency.
Learn morePyruvic Acid feeds into the citric acid cycle & converts into acetyl CoA. Pyruvate is formed from carbohydrate via glucose or glycogen & secondarily from fats (glycerol) & glycogenic amino acids.
Learn morePyruvic Acid feeds into the citric acid cycle & converts into acetyl CoA. Pyruvate is formed from carbohydrate via glucose or glycogen & secondarily from fats (glycerol) & glycogenic amino acids.
Learn morePyruvic Acid feeds into the citric acid cycle & converts into acetyl CoA. Pyruvate is formed from carbohydrate via glucose or glycogen & secondarily from fats (glycerol) & glycogenic amino acids.
Learn moreQuinolinic acid is a neurotoxic substance produced by our own bodies and a metabolite of tryptophan.
Learn moreQuinolinic acid is a neurotoxic substance produced by our own bodies and a metabolite of tryptophan.
Learn moreA high ratio of quinolinic acid to the tryptophan metabolite, 5-hydroxyindoleacetic acid, indicates excessive inflammation due to recurrent infections, excessive tryptophan intake, immune overstimulation, excessive adrenal production of cortisol, or
Learn moreIncreased urinary products of the omega fatty acid metabolism pathway may be due to carnitine deficiency, fasting, or increased intake of triglycerides from coconut oil, or some infant formulas.
Learn moreIncreased urinary products of the omega fatty acid metabolism pathway may be due to carnitine deficiency, fasting, or increased intake of triglycerides from coconut oil, or some infant formulas.
Learn moreSuberic Acid, Adipate, and Ethylmalonate elevations can indicate that you may need additional carnitine and/or vitamin B2 to assist your cells in converting fats into energy efficiently.
Learn moreSuberic Acid, Adipate, and Ethylmalonate elevations can indicate that you may need additional carnitine and/or vitamin B2 to assist your cells in converting fats into energy efficiently.
Learn moreSuberic Acid, Adipate, and Ethylmalonate elevations can indicate that you may need additional carnitine and/or vitamin B2 to assist your cells in converting fats into energy efficiently.
Learn moreSuccinate (or succinic acid) is an important metabolite that is involved in several chemical processes in the body.
Learn moreSuccinate (or succinic acid) is an important metabolite that is involved in several chemical processes in the body.
Learn moreSuccinate (or succinic acid) is an important metabolite that is involved in several chemical processes in the body.
Learn moreBreakdown product of hyaluronic acid; also found in some foods.
Learn moreBreakdown product of hyaluronic acid; also found in some foods.
Learn moreBreakdown product of hyaluronic acid; also found in some foods.
Learn moreA pyrimidine (DNA building block) that is elevated in the genetic disease dihydropyrimidine dehydrogenase deficiency. In this genetic disease, the pyrimidine uracil is also elevated. - Thymine is one of the five bases used to build nucleic acids.
Learn moreA pyrimidine (DNA building block) that is elevated in the genetic disease dihydropyrimidine dehydrogenase deficiency. In this genetic disease, the pyrimidine uracil is also elevated. - Thymine is one of the five bases used to build nucleic acids.
Learn moreA chemical byproduct released from fumonisins during passage through the gastrointestinal tract. Fumonisins are fungal toxins produced primarily by F. verticillioides. Elevated levels can be caused by the intake of corn or corn-based food contaminate
Learn moreA chemical byproduct released from fumonisins during passage through the gastrointestinal tract. Fumonisins are fungal toxins produced primarily by F. verticillioides. Elevated levels can be caused by the intake of corn or corn-based food contaminate
Learn moreA chemical byproduct released from fumonisins during passage through the gastrointestinal tract. Fumonisins are fungal toxins produced primarily by F. verticillioides. Elevated levels can be caused by the intake of corn or corn-based food contaminate
Learn moreA chemical byproduct released from fumonisins during passage through the gastrointestinal tract. Fumonisins are fungal toxins produced primarily by F. verticillioides. Elevated levels can be caused by the intake of corn or corn-based food contaminate
Learn moreThe pyrimidine metabolites are markers of folate metabolism. The two markers are uracil and thymine. Folate acts as a methyl donor in converting uracil to thymine. Elevated values of uracil suggest folic acid deficiency. Folate is needed to conver
Learn moreThe pyrimidine metabolites are markers of folate metabolism. The two markers are uracil and thymine. Folate acts as a methyl donor in converting uracil to thymine. Elevated values of uracil suggest folic acid deficiency. Folate is needed to conver
Learn moreThe pyrimidine metabolites are markers of folate metabolism. The two markers are uracil and thymine. Folate acts as a methyl donor in converting uracil to thymine. Elevated values of uracil suggest folic acid deficiency. Folate is needed to conver
Learn moreMetabolite of epinephrine and norepinephrine. Often elevated due to stress induced catecholamine output or lead toxicity.
Learn moreMetabolite of epinephrine and norepinephrine. Often elevated due to stress induced catecholamine output or lead toxicity.
Learn more