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Connective Tissue Disease Cascade

Serum

Performed by: LabCorp

The Connective Tissue Disease Cascade panel is an advanced diagnostic tool used for the detection and evaluation of autoimmune connective tissue diseases. This comprehensive panel includes a series of tests that identify specific antibodies commonly associated with these disorders, such as systemic lupus erythematosus, Sjögren's syndrome, scleroderma, polymyositis, and rheumatoid arthritis. By analyzing antibodies like ANA (Antinuclear Antibody), dsDNA, Smith antibodies, and others, the panel provides crucial information about the presence and type of autoimmune connective tissue disease a patient may have. This aids in early diagnosis, which is essential for effective management and treatment. The panel is particularly useful in cases where symptoms are unclear or overlap with multiple conditions, offering a detailed immunological profile that guides clinicians in their diagnostic and therapeutic decision-making. The Connective Tissue Disease Cascade panel is thus a vital resource in the field of rheumatology and autoimmune diagnostics, helping to tailor patient care more effectively.

Biomarkers included in this panel:

Anti-Beta2 Glycoprotein I IgG
Serum

Anti-Beta2 Glycoprotein I IgG is a specific class of autoantibodies directed against beta-2 glycoprotein I (β2GPI), a plasma protein that plays a critical role in the regulation of coagulation. The presence of these autoantibodies is clinically

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Anti-Beta2 Glycoprotein I IgM
Serum

Anti-Beta2 Glycoprotein I IgM antibodies are a critical serological marker in the field of immunology and hematology, particularly in the diagnosis and management of antiphospholipid syndrome (APS). Beta2 Glycoprotein I, a phospholipid-binding plasma

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