Hormone & Urinary Metabolites Assessment Profile
UrinePerformed by: Doctor's Data
The Hormone and Urinary Metabolites Assessment Profile (HuMap) provides a comprehensive overview of hormones and their metabolites, as well as efficiency of enzymes involved in their metabolism.
The Hormone and Urinary Metabolites Assessment Profile (HuMap) provides a comprehensive overview of steroid hormones, their metabolites, and the efficiency of the enzymes that metabolize these hormones. This non-invasive test requires only 4 or 5 separate urine collections. Because the breakdown of hormones relies so heavily on processes within the liver, this test can also help reveal patterns of liver metabolism and conjugation. Additionally, testing urinary hormone metabolites can contribute to further understanding of endogenous hormone secretion, supplemental hormone utilization, enzyme activity, oxidative stress, and insight into how your body metabolizes hormones.
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Biomarkers included in this panel:
11-Deoxycortisol has very little glucocorticoid activity yet its role as an intermediate in cortisol creation may assist in understanding of impairment along this pathway. CYP21A (21-hydroxylase) is responsible for the conversion of 17-hydroxyprogest
Learn more11-Deoxycortisol (Pre-menopausal)
11-Hydroxy-Androsterone (OHAN) is a urinary metabolite of cortisol metabolism as well as 11-oxygenated androgens production from the adrenal glands. While research is limited in the significance of elevations of this metabolite, it may be associated
Learn moreOHAN is a urinary metabolite of cortisol metabolism as well as 11-oxygenated androgens production from the adrenal glands.
Learn moreOHET is the product of cortisol metabolism as well as 11-oxygenated androgens produced from the adrenal gland. Levels tend to reflect levels of etiocholanolone.
Learn morePercentages of 2-OH-E1, 4-OH-E1, and 16-OH-E1 When evaluating phase I metabolism, it can be helpful to compare the percentages of 2, 4, and 16 OH-E1 metabolites. Most individuals metabolize the majority of their estrogens down the 2-OH-E1 pathway
Learn moreIn a Hormone Metabolite Assessment Panel (HUMAP) for pre-menopausal women, the percentage of 16-Hydroxyestrone (16-OH-E1) is a critical marker for evaluating estrogen metabolism and its implications for health. 16-OH-E1 is a metabolite of estrogen
Learn more16a-Hydroxyestrone, particularly in the context of a pre-menopausal Hormone Metabolite Assessment Panel (HUMAP), is a significant marker in understanding estrogen metabolism. Estrogens are a group of hormones critical for sexual and reproductive deve
Learn more17-OH Progesterone is the product of progesterone hydroxylation.
Learn more17-OH Progesterone is the product of progesterone hydroxylation.
Learn moreIn a Hormone & Urinary Metabolite Assessment Panel (HUMAP) for pre-menopausal women, the ratio of 2-Methoxyestradiol (2-M-E2) to 2-Hydroxyestrone (2-OH-E2) (2-M-E2:2-OH-E2) is an important marker of estrogen metabolism. Estrogens are metabolized
Learn morePercentages of 2-OH-E1, 4-OH-E1, and 16-OH-E1 When evaluating phase I metabolism, it can be helpful to compare the percentages of 2, 4, and 16 OH-E1 metabolites. Most individuals metabolize the majority of their estrogens down the 2-OH-E1 pathway
Learn moreIn a Hormone Metabolite Assessment Panel (HUMAP) for pre-menopausal women, the ratio of 2-Hydroxyestrone (2-OH-E1) to 16-Hydroxyestrone (16-OH-E1) is a critical metric for assessing estrogen metabolism and its implications for health. This ratio refl
Learn more21-Hydroxyprogesterone is a steroid hormone with mineralocorticoid properties produced in the adrenal gland which serves as a precursor hormone to aldosterone.
Learn more21-Hydroxyprogesterone is a steroid hormone with mineralocorticoid properties produced in the adrenal gland which serves as a precursor hormone to aldosterone.
Learn more4-OH-E2 is associated with a higher risk of certain cancers and other negative markers for breast health in females. Due to the lack of research in this area, it may be postulated that males carry a similar risk.
Learn moreHigher levels indicate slowed COMT activity (methylation) and are associated with a higher risk for breast cancer in females. Due to the lack of research in this area, it may be postulated that men carry a similar risk. Elevation may also be due to a
Learn more4-M-E2 (4-Methoxyestradiol) and 4-OH-E2 (4-Hydroxyestradiol) are two important estrogen metabolites whose levels are of particular interest in post-menopausal women, especially when assessed through a Hormone and Urinary Metabolites Assessment Profil
Learn moreMethyl metabolites are considered inactive and are correlated with antiproliferative effects. Proper elimination of 4-M-E2 requires optimal excretion via GI tract optimization. To fully understand this value, it may be beneficial to examine the 4-M-E
Learn more4-Methoxyestradiol is a metabolite of estradiol. 4-Methoxyestradiol is analyzed for its concentration and metabolic behavior in the human body. This analysis is vital for understanding its biological role and implications in various physiological and
Learn more4-Methoxyestrone is a metabolite of estrone, a form of estrogen, and is produced through the methoxylation process. This metabolite is considered to be a less active form of estrogen, having weaker estrogenic effects compared to other metabolites lik
Learn morePercentages of 2-OH-E1, 4-OH-E1, and 16-OH-E1 When evaluating phase I metabolism, it can be helpful to compare the percentages of 2, 4, and 16 OH-E1 metabolites. Most individuals metabolize the majority of their estrogens down the 2-OH-E1 pathway
Learn moreIn a Hormone Metabolite Assessment Panel (HUMAP) designed for pre-menopausal women, the percentage of 4-Hydroxyestrone (4-OH-E1) plays a crucial role in understanding estrogen metabolism and its associated risks. 4-OH-E1 is one of the metabolites of
Learn morePregnenetriol is a metabolite of 17a-pregnenolone, an intermediary resulting from the hydroxylation of pregnenolone by CYP17A1 enzyme.
Learn more5A-AD is a metabolite of 5αDHT. Research suggests: - that postmenopausal women may experience low levels of this metabolite. - elevations of this pathway in females maybe due to PCOS and hirsutism.
Learn more5A-DHT is converted from testosterone by 5-α reductase in the ovaries and peripherally in fat tissue.
Learn moreThe metabolic prioritization for alpha or beta reductase activity within the progesterone pathway may be confirmatory of a general preference of metabolism. Comparing these results with the metabolic preference of androgens and corticoids may provide
Learn moreThe metabolic prioritization for alpha or beta reductase activity within the progesterone pathway may be confirmatory of a general preference of metabolism. Comparing these results with the metabolic preference of androgens and corticoids may provide
Learn moreThe most important progesterone metabolite, pregnanediol (PDL), can serve as a urinary marker for endogenous progesterone levels and as an indicator of ovulation. PDL exists as two isomers, 5α-pregnanediol and 5β-pregnanediol. 5β-preg
Learn moreMetabolites of progesterone are measured in urine, including 5b-pregnanediol and 5a-pregnanediol. 5b-pregnanediol is inactive in the body but is the major metabolite of progesterone. 5a-pregnanediol is often a metabolite of more interest, as it can c
Learn more5B-THB is a terminal metabolite of corticosterone. This metabolite in combination with other terminal metabolites can be used to estimate metabolism of corticosterone. While research in elevations or low levels of single terminal metabolites is limit
Learn more5a-Tetrahydrocorticosterone (5a-THB) is a lesser-known metabolite of cortisol, and its measurement on a HUMAP panel can provide valuable insights, particularly for pre-menopausal females. 5a-THB is a part of the complex hormonal interplay within t
Learn more5A-THF is a terminal metabolite of cortisol metabolized via 5-alpha reductase. This metabolite along with the other terminal metabolites can be used to determine metabolized cortisol.
Learn moreThe relationship of the cortisol metabolites (5-alpha THF + THF) to cortisone metabolite (THE) is another tool in the assessment of the dominance of active cortisol or inactive cortisone.
Learn moreThe 5A-THF/5B-THF ratio is a calculation used to show the preference of 5-alpha reductase activity to 5-beta reductase activity. While research is limited in the significance of 5-alpha or 5-beta reductase activity in the glucocorticoids, it can serv
Learn more5B-AD is the result of 5-beta reduction of DHT as well as a metabolite of etiocholanolone.
Learn moreThe most important progesterone metabolite, pregnanediol (PDL), can serve as a urinary marker for endogenous progesterone levels and as an indicator of ovulation. PDL exists as two isomers, 5α-pregnanediol and 5β-pregnanediol. 5β-preg
Learn more5B-PD is the major progesterone metabolite. Progesterone is produced by the corpus luteum following ovulation and to a lesser extent by the adrenal glands in both sexes. While found in the urine in small amounts, progesterone can be seen as a clin
Learn more5B-THB is a terminal metabolite of corticosterone. This metabolite in combination with other terminal metabolites can be used to estimate metabolism of corticosterone. While research in elevations or low levels of single terminal metabolites is limit
Learn more5B-THF is a terminal metabolite of cortisol metabolized via 5-beta reductase. This metabolite along with the other terminal metabolites can be used to determine metabolized cortisol.
Learn more8-hydroxy-2’-deoxyguanosine is marker resulting from DNA damage due to oxidative stress.
Learn moreAllopregnanolone is a potent neuroactive steroid capable of binding the GABA-A receptor often leading to sedative and anxiolytic action. The calming action of allopregnanolone is often seen with orally supplemented progesterone, as the liver metaboli
Learn moreAllopregnanolone is a downstream metabolite of progesterone considered a neurosteroid due to its ability to influence the GABA-A receptor, creating anxiolytic effects. Progesterone is produced by the corpus luteum following ovulation and to a less
Learn moreAndrostenedione is a weak androgen secreted by adrenal glands, testes, and ovaries that is converted to testosterone or estrone in the periphery.
Learn moreThe ratio of Androsterone (5a) to Etiocholanolone (5b) in a Human Urinary Metabolic Profile (HUMAP) panel is a critical marker for assessing the balance of androgen metabolism in the body. Androsterone and Etiocholanolone are both metabolites of test
Learn moreAndrosterone is the product of androgens metabolized by 5-alpha reductase. It acts as a neurosteroid and a weak potentiator of GABA-A receptor activity.
Learn moreCorticosterone is a precursor hormone to aldosterone. Research is limited in the clinical significance of both elevated or low corticosterone and may be due to levels of precursor hormones.
Learn moreCortisol is the main glucocorticoid released from the adrenal gland in response to stress. High levels of cortisol have been reported in cases of Cushing’s disease, malnutrition, early life stress, hypothyroidism, depression, alcoholism, obesit
Learn moreThe Cortisol Bedtime marker is a critical indicator in endocrinology, representing the level of cortisol in the body at bedtime. Cortisol, a hormone produced by the adrenal glands, is central to various physiological processes, including stress respo
Learn moreCortisol is the main glucocorticoid released from the adrenal gland in response to stress. High levels of cortisol have been reported in cases of Cushing’s disease, malnutrition, early life stress, hypothyroidism, depression, alcoholism, obesit
Learn moreCortisol, often referred to as the "stress hormone," plays a crucial role in various bodily functions, including metabolism, immune response, and the body's response to stress. The Cortisol Dinnertime marker, a specific measure of corti
Learn moreCortisol is the main glucocorticoid released from the adrenal gland in response to stress. High levels of cortisol have been reported in cases of Cushing’s disease, malnutrition, early life stress, hypothyroidism, depression, alcoholism, obesit
Learn moreCortisol is the main glucocorticoid released from the adrenal gland in response to stress. High levels of cortisol have been reported in cases of Cushing’s disease, malnutrition, early life stress, hypothyroidism, depression, alcoholism, obesit
Learn moreCortisol / cortisone ratio indicates activity of HSD11B2 activity and assessment of tissue specific concentrations of cortisol, which normally cannot be measured without a biopsy.
Learn moreCortisol is the main glucocorticoid released from the adrenal gland in response to stress. High levels of cortisol have been reported in cases of Cushing’s disease, malnutrition, early life stress, hypothyroidism, depression, alcoholism, obesit
Learn moreThe Cortisol/day measurement on a HUMAP panel is a crucial indicator of cortisol levels throughout a typical day, reflecting the hormone's diurnal pattern and its overall balance in the body. Cortisol, produced by the adrenal glands, is integral
Learn moreCortisone is the inactive form of cortisol. Elevations of cortisone may reflect high cortisol production, excessive 11BHSD2 activity, or insufficient conversion by 11BHSD1.
Learn moreCortisone Bedtime as measured on a HUMAP panel is a significant indicator of cortisone levels in the body at bedtime. Cortisone, a metabolite of cortisol, plays a key role in various physiological functions, including the regulation of inflammation,
Learn moreCortisone is the inactive form of cortisol. Elevations of cortisone may reflect high cortisol production, excessive 11BHSD2 activity, or insufficient conversion by 11BHSD1.
Learn moreCortisone Dinnertime on a HUMAP panel represents the measurement of cortisone levels in the body during the evening. Cortisone is a steroid hormone and is closely related to cortisol, often referred to as the "stress hormone." While cortiso
Learn moreCortisone is the inactive form of cortisol. Elevations of cortisone may reflect high cortisol production, excessive 11BHSD2 activity, or insufficient conversion by 11BHSD1.
Learn moreCortisone is the inactive form of cortisol. Elevations of cortisone may reflect high cortisol production, excessive 11BHSD2 activity, or insufficient conversion by 11BHSD1.
Learn moreCortisone is the inactive form of cortisol. Elevations of cortisone may reflect high cortisol production, excessive 11BHSD2 activity, or insufficient conversion by 11BHSD1.
Learn moreDehydroepiandrosterone (DHEA) is predominantly produced in the adrenal glands and serves as a precursor hormone for androstenedione and eventually estrone and testosterone. High levels of DHEA may be due to DHEA or pregnenolone supplementation. Addit
Learn moreDehydroepiandrosterone (DHEA) is a hormone predominantly produced in the adrenal glands which serves as precursor hormone for androstenedione and eventually estrone and testosterone.
Learn moreDehydroepiandrosterone sulfate or DHEA-S is the sulfated form of dehydroepiandrosterone (DHEA) and the major steroid precursor in humans. This sulfation is reversibly catalyzed by sulfotransferase 2A1 (SULT2A1) primarily in the adrenals, the liver, a
Learn moreDehydroepiandrosterone sulfate or DHEA-S is the sulfated form of dehydroepiandrosterone (DHEA) and the major steroid precursor in humans. This sulfation is reversibly catalyzed by sulfotransferase 2A1 (SULT2A1) primarily in the adrenals, the liver, a
Learn moreDHEA and DHEAs are produced in the adrenal gland and serve as precursors to androgens and estrogens. Due to the interconversion between DHEA and DHEAS via SULT2A1 and/or STS, the sum of these maybe a better representation of total DHEA synthesis.
Learn moreDHEA and DHEAs are produced in the adrenal gland and serve as precursors to androgens and estrogens. Due to the interconversion between DHEA and DHEAS via SULT2A1 and/or STS, the sum of these may be a better representation of total DHEA synthesis.
Learn moreEstradiol level is most consistent with exogenous exposure, supplementation, or aromatization of testosterone to estradiol. CYP19, also known as aromatase, can be upregulated raising intracellular estrogens in men which can contribute to increased ad
Learn moreIn a Hormone Metabolite Assessment Panel (HUMAP) for pre-menopausal women, estradiol plays a pivotal role as a primary estrogen hormone. Estradiol is not just a crucial marker for assessing overall estrogenic activity but also for understanding a wom
Learn moreEvaluation of the estrogen metabolism pathway relies on understanding several key steps of metabolism: the amount of unconjugated estrogens, hydroxylation of E1 and E2, methylation of hydroxy estrogens, and the function of key enzymes. Evaluation
Learn moreIn the context of a Hormone Metabolite Assessment Panel (HUMAP) for pre-menopausal women, Estriol plays a unique and informative role in the spectrum of estrogen metabolites. Estriol, a weaker estrogen compared to estradiol and estrone, is predominan
Learn moreA component of the estrone level may be due to aromatization of androstenedione and testosterone by CYP19 (aromatase) enzyme in adipose tissue, and/or conversion from estradiol due to HSD17B activity. Aromatase up-regulation and increased intracellul
Learn moreEstrone is one of the three major naturally occurring estrogens, alongside estradiol and estriol. Estrone, as a marker in a Human Urinary Metabolic Profile (HUMAP) panel for pre-menopausal women, offers valuable insights into estrogen metabolism a
Learn moreEtiocholanolone is a 5-beta reduced isomer of androsterone, and a major metabolite of testosterone and androstenedione, however it is not active as an androgen.
Learn moreProgesterone is produced by the corpus luteum following ovulation and to a lesser extent by the adrenal glands in both sexes. While found in the urine in small amounts, progesterone can be seen as a clinical marker of luteal activity and therapu
Learn moreProgesterone is produced by the corpus luteum following ovulation and to a lesser extent by the adrenal glands in both sexes. While found in the urine in small amounts, progesterone can be seen as a clinical marker of luteul activity and theraputic o
Learn moreTestosterone is the major anabolic androgen found in females. Because urinary testosterone levels are independent of circadian rhythm fluctuation, urine may be a better medium than serum to indicate androgen production.
Learn moreThe ratio of Testosterone to Epi-Testosterone in pre-menopausal women, as part of a Human Urinary Metabolic Profile (HUMAP) panel, is a significant indicator of hormonal balance and metabolic function. Testosterone, although primarily considered a ma
Learn moreTetrahydrocortisone is a terminal metabolite of cortisone. This metabolite along with the other terminal metabolites can be used to determine metabolized cortisol. Research in elevations or low levels of single terminal metabolites is limited, assess
Learn moreTHE is a terminal metabolite of cortisone. This metabolite along with the other terminal metabolites can be used to determine metabolized cortisol. Research in elevations or low levels of single terminal metabolites is limited, assessing metabolized
Learn more5B-THA is a terminal metabolite of corticosterone. This metabolite in combination with other terminal metabolites can be used to estimate metabolism of corticosterone. While research in elevations or low levels of single terminal metabolites is limit
Learn moreThis calculation includes the daily metabolites of cortisol (5-alpha THF, THF) and cortisone (THE) which maybe a better representation of daily cortisol output than measuring cortisol and cortisone alone due to metabolism differences in the liver (wi
Learn moreThis calculation includes the daily metabolites of cortisol (5-alpha THF, THF) and cortisone (THE) which maybe a better representation of daily cortisol output than measuring cortisol and cortisone alone due to metabolism differences in the liver (wi
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