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YO AB Screen w/Reflex to Titer and WB, Serum

Serum

Performed by: Quest Diagnostics

The YO AB Screen with Reflex to Titer and Western Blot (WB), Serum, is a specialized diagnostic panel primarily used for detecting paraneoplastic neurological syndromes, particularly in the context of suspected ovarian or breast cancer. This test screens for anti-Yo antibodies, which are associated with paraneoplastic cerebellar degeneration (PCD), a condition where the immune system, in response to a cancer, mistakenly attacks the central nervous system. If the initial screening is positive, the test reflexively proceeds to a titer to quantify the antibody levels and a Western Blot for further confirmation. The presence and level of anti-Yo antibodies can assist in diagnosing PCD and may also indicate an underlying malignancy, often before the cancer is clinically detectable. This makes the test a valuable tool for early cancer detection and managing associated neurological complications. The YO AB Screen with Reflex to Titer and WB is crucial for providing comprehensive care in oncology and neurology, reflecting the importance of integrated diagnostics in early detection and intervention for cancer-related neurological disorders.

Biomarkers included in this panel:

YO Ab Screen, IFA, Serum
Serum

The YO Ab Screen, IFA (Immunofluorescence Assay), Serum test is a crucial diagnostic marker used primarily in neurology and oncology to detect paraneoplastic neurological syndromes, especially paraneoplastic cerebellar degeneration (PCD) associated w

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