- High glyceric levels on an organic acids test usually relates to primary hyperoxaluria type 2. In this condition there is a deficiency of glyoxylate reductase/hydroxypyruvate reductase (GRHFR). Whereas primary hyperoxaluria type 1 can lead to kidney failure, primary hyperoxaluria type 2 is more likely to cause the formation of kidney stones.
- Elevated levels of glyceric acid in addition to an elevation in oxalates on the OAT test indicates the presence of the type 2 GRHPR genetic variance.
- Elevated values may also be due to microbial sources such as yeast (Aspergillus, Penicillium, probably Candida) or due to dietary sources containing glycerol (glycerine). Glyceric acid is isolated from various plants (e.g. brassicas, pulses, and Vicia faba).
Low levels of glyceric acid in an organic acid test can be indicative of various metabolic conditions, although it's not as commonly discussed or as straightforward in interpretation as high levels are. Organic acid tests are specialized diagnostic tools used to detect abnormalities in the body's metabolic processes, which can reveal insights into a person's overall health, including nutrient deficiencies, the presence of unusual bacteria or yeasts, and the efficiency of metabolic pathways. Specifically, glyceric acid is a marker that can help assess carbohydrate metabolism and mitochondrial function among other things. A decrease in glyceric acid levels could potentially point towards an inefficiency in glycolysis (the process of breaking down glucose for energy) or issues with mitochondrial function, although it's important to note that interpretations can be complex and context-dependent.
→ Causes of altered glyceric acid levels can range from genetic metabolic disorders to nutritional deficiencies, or even environmental factors.
→ Symptoms associated with metabolic imbalances can vary widely, from fatigue and weakness to more severe neurological or developmental issues, depending on the underlying cause and the specific metabolic pathways affected.
→ Treatment options also vary significantly based on the diagnosis. They can include dietary modifications, supplementation to correct deficiencies, or more specific treatments aimed at managing symptoms or addressing the underlying metabolic pathways involved.
Additional note: As with any diagnostic test, results from an organic acid test, including glyceric acid levels, should be interpreted by a healthcare professional within the context of the individual's overall health, symptoms, and medical history to ensure accurate diagnosis and appropriate treatment planning.
The organic acids test by Great Plains Laboratory measures a few oxalate metabolites which can determine if someone has high oxalate levels. These include oxalic, glycolic, and glyceric.
In humans and in yeast, glyoxalate is the parent compound that can be converted into the three metabolites measured on the Organic Acids Test (OAT): glyceric, glycolic, and oxalic acid.
Normal values rule out genetic causes of significantly elevated urinary oxalic acid.
Glyceric
