Organic Acids Test (OAT) - Nutritional and Metabolic Profile

Glutaric

Optimal result: 0.04 – 0.36 mmol/mol creatinine

Mosaic Diagnostics

By Healthmatters Editorial Team

Peer-reviewed sources

Elevation indicates riboflavin (vitamin B2) deficiency. Other possible factors include fatty acid oxidation defects, and metabolic effects of valproic acid (Depakene), or celiac disease. The probability of a genetic disease is higher with very high values. The use of dietary supplements containing riboflavin and coenzyme Q10 may improve clinical symptoms. This compound may be elevated in about 10% of children with autism.

Possible causes:

- Low B2

- Inborn error of metabolism

- Associated with CETP genetic polymorphism

Additional investigations:

- Red blood cell B2

- Genetic Diagnostic Testing

Treatment considerations:

- Supplement B2

- Consider mitochondrial support nutrients (e.g. CoQ10)

Glutaric acid is made from lysine & tryptophan via alphaketo-adipic acid.

- Elevated in the genetic diseases glutaric academia types I and II.
- Moderate increases may be due to deficiencies in riboflavin and coenzyme Q10, or celiac disease.
- Moderate increases are common in autism possibly due to defective vitamin absorption or microbial production in the GI tract.

Elevation indicates riboflavin deficiency (vitamin B2), a common factor in moderate urinary increases of glutaric acid.

Other possible factors include:

- fatty acid oxidation defects

- metabolic effects of valproic acid (Depakene),

- or celiac disease.

The probability of a genetic disease is higher with very high values.

The use of dietary supplements containing riboflavin and coenzyme Q10 may improve clinical symptoms.

This compound may be elevated in about 10% of children with autism.

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Written by Healthmatters Editorial Team

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