2-Hydroxyhippuric (Females Under Age 13)

Optimal result: 0 – 1.2 mmol/mol creatinine

High 2-hydroxyhippuric acid may result from: 

- ingestion of aspartame (Nutrasweet)

- salicylates (aspirin)

- dietary salicylates

- from GI bacteria converting tyrosine or phenylalanine to salicylic acid. 

Very high 2-hydroxyhippuric also inhibits dopamine beta-hydroxylase resulting in elevated HVA, decreased VMA, and elevated HVA/VMA ratio.

2-Hydroxyhippuric acid is a conjugate of hydroxybenzoic acid (salicylic acid) and glycine.

A conjugate of the amino acids, glycine and hydroxybenzoic acid (salicylic acid). Intake of aspirin (salicylates) or the growth of salicylate-producing gastrointestinal bacteria may elevate levels. Also increased after the ingestion of the arti cial sweetener, aspartame (Nutrasweet).

2-Hydroxyhippuric (Females Under Age 13)
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