Arabinose (Males Under Age 13)

Elevated arabinose levels on an Organic Acids Test (such as the one by Mosaic Diagnostics) in a male under age 13 typically indicate a fungal or yeast overgrowth in the gastrointestinal tract. Arabinose is a sugar metabolite produced mainly by Candida species and other yeast organisms. When these organisms grow excessively, arabinose levels in urine often rise.

Clinical implications of elevated arabinose in children:

• Candida or fungal overgrowth:
  The most common cause is gastrointestinal yeast overgrowth, frequently Candida albicans. Children might exhibit digestive symptoms (bloating, gas, constipation, diarrhea), behavioral or cognitive changes (hyperactivity, irritability, attention difficulties), skin rashes, recurrent infections, or fatigue.

• Potential gut dysbiosis:
  Elevated arabinose may indicate disrupted gut flora balance, possibly due to antibiotic use, high sugar diets, or compromised immunity.

• Influence on neurological and behavioral health:
  Candida overgrowth and elevated arabinose levels have been associated with symptoms similar to those seen in children diagnosed with autism spectrum disorders, ADHD, or other developmental conditions.

Recommended next steps:

• Dietary adjustments: Reduce sugar and refined carbohydrates to limit yeast proliferation.
• Probiotics and gut-supportive nutrients: Introduce beneficial bacteria through probiotics or fermented foods.
• Antifungal treatment: Consider natural antifungals (such as caprylic acid, oregano oil, or grapefruit seed extract) or pharmaceutical antifungals under the guidance of a healthcare provider.
• Further clinical evaluation: Consult a practitioner knowledgeable in pediatric gut health to determine underlying causes and appropriate interventions.

Elevated arabinose is a valuable marker indicating a need for improved gut microbiome balance, particularly in young children.

Produced by action of Candida hyaluronidase on the intercellular cement, hyaluronic acid. Oxidation of the hyaluronic acid breakdown by white blood cell hypochlorite produces tartaric acid and arabinose. Antifungal treatment and high-potency, multi-strain probiotics may help rebalance GI flora.