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Yersinia IgG-/IgA-antibodies

YO AB Screen w/Reflex to Titer and WB, Serum

The YO AB Screen with Reflex to Titer and Western Blot (WB), Serum, is a specialized diagnostic panel primarily used for detecting paraneoplastic neurological syndromes, particularly in the context of suspected ovarian or breast cancer. This test screens for anti-Yo antibodies, which are associated with paraneoplastic cerebellar degeneration (PCD), a condition where the immune system, in response to a cancer, mistakenly attacks the central nervous system. If the initial screening is positive, the test reflexively proceeds to a titer to quantify the antibody levels and a Western Blot for further confirmation. The presence and level of anti-Yo antibodies can assist in diagnosing PCD and may also indicate an underlying malignancy, often before the cancer is clinically detectable. This makes the test a valuable tool for early cancer detection and managing associated neurological complications.