Viral Panel Comprehensive
Performed by: Immunosciences Lab, Inc.
Understand your immune system’s response to common and clinically significant viruses
The Viral Panel Comprehensive evaluates your body’s immune response to a group of important viruses, including herpesviruses (HSV, HHV-6, EBV), cytomegalovirus (CMV), measles, and varicella-zoster. These pathogens are widespread, and many people are exposed to them during childhood or adolescence. While most infections remain silent or mild, in some individuals they can contribute to chronic symptoms, immune dysregulation, or viral reactivation.
This panel measures both IgG (long-term immunity or past exposure) and IgM (recent or active immune response) antibodies. Together, these markers help identify whether your immune system is responding to a current infection, showing evidence of a past infection, or displaying patterns that may suggest viral reactivation.
What This Panel Helps You Understand
1. Past Exposure vs. Recent Infection
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IgG antibodies indicate previous contact with a virus and long-term immune memory.
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IgM antibodies can signal a more recent or active response.
This distinction is essential when evaluating symptoms such as fatigue, swollen lymph nodes, recurrent infections, or suspected viral reactivation.
2. Viral Reactivation Patterns
Some viruses—especially Epstein-Barr virus (EBV) and Human Herpesvirus-6 (HHV-6)—can remain dormant and reactivate under certain conditions. Reactivation may contribute to:
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Chronic fatigue
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Immune dysfunction
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Autoimmune processes
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Neurological symptoms
The panel includes markers that help identify possible reactivation, such as EBV Early Antigen or elevated IgM levels in the absence of an acute infection.
3. Immunity Status for Childhood Viruses
Markers for measles, varicella-zoster (chickenpox), and CMV help determine whether you have protective immunity or evidence of recent exposure. This is particularly useful for:
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Children
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Immunocompromised individuals
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People evaluating vaccine immunity
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Anyone with recurrent or unexplained viral symptoms
Who This Panel Is Helpful For
This panel is often used by clinicians when evaluating:
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Persistent fatigue, flu-like symptoms, or unexplained malaise
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Suspected EBV or HHV-6 involvement
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Immune system dysregulation
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Chronic inflammatory or autoimmune conditions
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Recurrent viral infections
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Immune status in children or adolescents
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Follow-up after previous abnormal viral titers
What the Results Mean
Your report will show each viral marker with:
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Your measured value
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Reference ranges
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Whether the result suggests past exposure, active infection, immunity, or reactivation patterns
This makes it easier to see how your immune system is interacting with each virus.
For example:
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Negative IgG and IgM → No evidence of prior or current infection
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Positive IgG, negative IgM → Past infection or immunity
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Positive IgM → Recent or ongoing immune activity
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EBV Early Antigen elevation → Possible reactivation
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High HHV-6 IgM → Possible active or reactivated HHV-6 response
Why These Viruses Matter
Herpesviruses—such as EBV, CMV, HSV, and HHV-6—establish lifelong latency in the body. For most people this is harmless, but in others these viruses can influence:
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Energy levels
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Neurological function
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Autoimmune activity
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Susceptibility to other infections
Identifying which viruses the immune system is responding to can be an important step in understanding chronic or unexplained symptoms.
Takeaway
The Viral Panel Comprehensive provides a detailed look at how your immune system interacts with some of the most common and clinically relevant viruses. Whether you’re evaluating new symptoms, monitoring an ongoing condition, or simply confirming immune status, this panel helps provide clarity and direction for next steps.
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Biomarkers included in this panel:
IgG to the Epstein–Barr Virus Early Antigen (EA) helps evaluate whether the virus may have been active or reactivated at some point. Early Antigen is a protein produced during the early phase of EBV replication. While most people only develop l
Learn moreIgG EB Nuclear Antigen (EBNA IgG) measures long-term antibodies produced after infection with Epstein–Barr virus (EBV). EBNA IgG is a key marker because it typically appears later in the infection, often several months after the initial illness
Learn moreIgG Epstein–Barr Virus Viral Capsid Antigen (EBV VCA IgG) measures long-term antibodies produced after infection with Epstein–Barr virus (EBV)—one of the most common human viruses. EBV typically causes infectious mononucleosis (&ldq
Learn moreIgM Cytomegalovirus (CMV) measures the level of IgM antibodies, which are the body’s first line of defense when encountering a virus. These antibodies typically appear during a new CMV infection or during viral reactivation. Because CMV is a co
Learn moreIgM EB Nuclear Antigen (EBNA IgM) measures early antibodies directed against the Epstein–Barr Virus (EBV) Nuclear Antigen. Unlike other EBV markers, such as VCA IgM, EBNA IgM is not commonly produced and is generally not a standard marker of ac
Learn moreIgM Epstein–Barr Virus Viral Capsid Antigen (EBV VCA IgM) measures early antibodies produced by the immune system during a new or recent Epstein–Barr virus infection. EBV is a common virus best known for causing infectious mononucleosis (
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