MALE: First AM Comp - Urine Profile + Metabolites (Physicians Lab)

a urinary metabolite of cortisol metabolism

Urinary androgen

The 2-Methoxy Estrogens are considered to be protective.

Androgenic testosterone metabolite via 5a pathway

a-THF

Alpha-Pregnanediol in men's urine is a metabolite of progesterone, a hormone present in males but at lower levels compared to premenopausal women. Progesterone is primarily produced in the corpus luteum following ovulation in women and to a lesser extent in the adrenal glands of both sexes. In men, it plays a role in the production of testosterone and sperm development. In the male body, progesterone undergoes metabolic pathways, leading to the production of two isomers of Alpha-Pregnanediol, namely 5α-pregnanediol (5A-PD) and 5β-pregnanediol (5B-PD). Among these isomers, 5B-PD represents the majority endpoint of endogenous progesterone metabolism and is considered to have little physiological activity. On the other hand, 5A-PD, the lesser metabolite of progesterone, can cross the blood-brain barrier and partially agonize GABA-A receptors. This action is likely due to its role as a precursor to allopregnanolone, a potent neuroactive steroid capable of binding the GABA-A receptor, leading to calming, sedative, and anxiolytic effects. Since Alpha-Pregnanediol levels are related to progesterone metabolism, they can be a valuable marker in monitoring hormone therapy, including supplementation of oral progesterone or pregnenolone. It's essential to consider these levels alongside other androgen and progesterone markers to gain a comprehensive understanding of the individual's hormonal status. References: [1]

Alpha-Pregnanediol and Beta-Pregnanediol are metabolites of progesterone, and they are used as surrogate markers because they are the most abundant metabolites. The ratio between these two metabolites can provide insights into the relative activity of specific steroidogenic enzymes or pathways involved in progesterone metabolism.

Elevated Beta-Pregnanediol (b-Pregnanediol) in men's urine signifies an imbalance in progesterone metabolism. Beta-Pregnanediol is a metabolite of progesterone, a hormone that is present in men, albeit at lower levels compared to premenopausal women. Progesterone is primarily produced in the corpus luteum following ovulation in women and to a lesser extent in the adrenal glands of both sexes. In men, it plays a role in the production of testosterone and sperm development. When Beta-Pregnanediol levels are elevated, it indicates an increased metabolism of progesterone through specific pathways. The metabolism of progesterone leads to the production of two isomers of Beta-Pregnanediol, namely 5α-pregnanediol and 5β-pregnanediol. Both Alpha-Pregnanediol and Beta-Pregnanediol are used as surrogate markers since they are the most abundant metabolites of progesterone.

indicates activity of HSD11B2

Dehydroepiandrosterone is a 17-Ketosteroid produced primarily by the adrenal gland by side chain cleavage of 17-Hydroxy Pregnenolone. It is reversibly converted to Dehydroepiandrosterone-Sulfate and Androstenediol. It is also converted to Androstenedione. It is excreted in the urine as Sulfate and Glucuronide conjugates and unconjugated (Free) forms. Free DHEA urine is excreted into the urine primarily from Free (unbound) blood DHEA. DHEA urine is one of the first androgens to increase significantly at the onset of adrenache. Levels increase throughout puberty until adulthood. In females, levels drop off sharply after menopause. DHEA may distinguish adrenal causes of overandrogenization from gonadal causes.

main urinary metabolite of 11-deoxycortisol.