- Alistipes does not contribute significantly to short chain fatty acid production.

- A diet rich in animal protein and fat increases the abundance of Alistipes.

- High abundance of Alistipes was identified as a possible predictor of successful weight loss.

- Alistipes may positively correlate with depression.

Alistipes does not contribute significantly to short chain fatty acid production. A diet rich in animal protein and fat increases the abundance of Alistipes. High abundance of Alistipes was identified as a possible predictor of successful weight loss. Increased abundance of Alistipes has been correlated with a greater frequency of pain in pediatric irritable bowel syndrome patients.

What is Alkaline phosphatase (ALP)?

Alkaline phosphatase (ALP) is an enzyme (= enzymes are proteins that act as biological catalysts by accelerating chemical reactions) found in the blood that helps break down proteins and that plays a role in numerous processes in the human body. Any abnormalities in blood concentrations (either high or low) may be indicative of diseases ranging from gallstones and thyroid disease to hepatitis and cancer.

ALP is found in all tissues of the body but, not surprisingly, is found in its highest concentration in the liver, bones, kidneys, and intestines as well as the bile ducts (that drain bile from the liver) and gallbladder (that stores bile).

Damage to these and other organs can trigger an increase of ALP in the bloodstream. By contrast, certain diseases or conditions can impair ALP synthesis and lead to a drop in the blood concentration.

Allo-Tetrahydrocorticosterone (5α-THB) is a significant biomarker in dried urine panel analysis, offering vital insights into the body's hormonal balance and stress response. As a metabolite of cortisol, 5α-THB is crucial in understanding the body's glucocorticoid activity, a fundamental aspect of the stress response mechanism. Cortisol, produced by the adrenal glands, is known as the "stress hormone," playing a pivotal role in various physiological processes including metabolism regulation, immune response modulation, and stress adaptation. In the metabolic pathway, cortisol is reduced to tetrahydrocortisol (THF) and subsequently transformed into 5α-THB. This conversion is catalyzed by the enzyme 5α-reductase, which also participates in other critical physiological processes such as androgen metabolism.

Metabolized cortisol is the sum of a-tetrahydrocortisol (a-THF), b-tetrahydrocortisol (b-THF), and b-tetrahydrocortisone (b-THE). They are a good indication of the total cortisol output from the adrenal gland or clearance out the body.

This marker is part of the "17-Hydroxysteroids" group. Please refer to the "17-Hydroxysteroids, Total" marker.

This marker is part of the "17-Hydroxysteroids" group. Please refer to the "17-Hydroxysteroids, Total" marker.

This marker is part of the "17-Hydroxysteroids" group. Please refer to the "17-Hydroxysteroids, Total" marker.

Allo-isoleucine is nearly undetectable in individuals not affected by maple-syrup urine disease (MSUD). Accordingly, its presence is diagnostic for MSUD, and its absence is sufficient to rule-out MSUD.

Allo-isoleucine is nearly undetectable in individuals not affected by maple-syrup urine disease (MSUD). Accordingly, its presence is diagnostic for MSUD, and its absence is sufficient to rule-out MSUD.

Allopregnanediol, or 5a-pregnane-3a,20a-diol, is an endogenous metabolite of progesterone and allopregnanolone and an isomer of pregnanediol.

Allopregnanediol, or 5a-pregnane-3a,20a-diol, is an endogenous metabolite of progesterone and allopregnanolone and an isomer of pregnanediol. Progesterone is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans. It belongs to a group of steroid hormones called the progestogens and is the major progestogen in the body. Progesterone has a variety of important functions in the body. It is also a crucial metabolic intermediate in the production of other endogenous steroids, including the sex hormones and the corticosteroids, and plays an important role in brain function as a neurosteroid. In addition to its role as a natural hormone, progesterone is used as a medication, for instance in menopausal hormone therapy.

Allopregnanolone, also known as brexanolone, is a medication and a naturally produced steroid that acts on the brain. Allopregnanolone possesses a wide variety of effects, including, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding, prosocial, antiaggressive, prosexual, sedative, pro-sleep, cognitive, memory-impairment, analgesic, anesthetic, anticonvulsant, neuroprotective, and neurogenic effects.

Allopregnanolone is a potent neuroactive steroid capable of binding the GABA-A receptor often leading to sedative and anxiolytic action. The calming action of allopregnanolone is often seen with orally supplemented progesterone, as the liver metabolizes a large portion of oral progesterone to the neuroactive steroid allopregnanolone.

Allopregnanolone, a neurosteroid of growing interest in male health. This metabolite of progesterone plays a crucial role in modulating brain function, particularly influencing mood, stress response, and cognitive processes. In men, allopregnanolone levels are essential for maintaining neurological and psychological well-being. Abnormal levels of allopregnanolone can be indicative of various health issues, ranging from mood disorders to neurodegenerative diseases. The inclusion of allopregnanolone in ZRT's urinary neurotransmitter panel allows for a more comprehensive assessment of a patient's neuroendocrine status, contributing to a deeper understanding of the complex interplay between hormones and neurotransmitters in men's health. 

Allopregnanolone, also known as brexanolone, is a medication and a naturally produced steroid that acts on the brain. Allopregnanolone possesses a wide variety of effects, including, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding, prosocial, antiaggressive, prosexual, sedative, pro-sleep, cognitive, memory-impairment, analgesic, anesthetic, anticonvulsant, neuroprotective, and neurogenic effects.

Allopregnanolone is a downstream metabolite of progesterone considered a neurosteroid due to its ability to influence the GABA-A receptor, creating anxiolytic effects.

Progesterone is produced by the corpus luteum following ovulation and to a lesser extent by the adrenal glands in both sexes. While found in the urine in small amounts, progesterone can be seen as a clinical marker of luteul activity and theraputic oral progesterone administration. The most important progesterone metabolite, pregnanediol (PDL), can serve as a urinary marker for endogenous progesterone levels and as an indicator of ovulation. PDL exists as two isomers, 5α-pregnanediol and 5β-pregnanediol.

5β-pregnanediol represents the majority end point of endogenous progesterone metabolism and appears to have little activity within the body, while 5α-pregnanediol, the lesser metabolite of PDL, can cross the blood brain barrier and may partially agonize GABA-A receptors.

This action is possibly due to its role as an immediate precursor to allopregnanolone. Allopregnanolone is a potent neuroactive steroid capable of binding the GABA-A receptor often leading to sedative and anxiolytic action. The calming action of allopregnanolone is often seen with orally supplemented progesterone, as the liver metabolizes a large portion of oral progesterone to the neuroactive steroid allopregnanolone.

Allopregnanolone is a neurosteroid hormone that plays a significant role in the context of postmenopausal women. During the menopausal transition, there is a notable reduction in allopregnanolone levels, primarily due to decreased ovarian synthesis of progesterone. This hormonal change can have implications for mood and cognition.