5a-DHT is a testosterone metabolite. 

5a-DHT is essential for the development of the male sex characteristics before birth, particularly the formation of the external genitalia. In the adult, 5a-DHT is needed to develop and maintain male gender characteristics, such as facial hair, deep voice, and muscle growth. In women, 5a-DHT may induce the onset of puberty and causes the body and pubic hair growth.

Increased 5a-DHT levels are found in about 40% of patients with idiopathic hirsutism and 35% of patients with polycystic ovarian syndrome (=PCOS).

5a-Dihydrotestosterone (5a-DHT), a potent androgen, is a crucial marker in the ZRT Laboratory Urinary Neurotransmitters panel, underscoring its significance in male health and hormonal research. 5a-DHT, derived from testosterone via the enzyme 5-alpha reductase, plays a key role in male physiology, including the development of male characteristics, maintenance of prostate health, and regulation of hair growth.

5A-DHT is converted from testosterone by 5-α reductase in the ovaries and peripherally in fat tissue.

The metabolic prioritization for alpha or beta reductase activity within the progesterone pathway may be confirmatory of a general preference of metabolism. Comparing these results with the metabolic preference of androgens and corticoids may provide additional insight.

The metabolic prioritization for alpha or beta reductase activity within the progesterone pathway may be confirmatory of a general preference of metabolism. Comparing these results with the metabolic preference of androgens and corticoids may provide additional insight.

The most important progesterone metabolite, pregnanediol (PDL), can serve as a urinary marker for endogenous progesterone levels and as an indicator of ovulation. PDL exists as two isomers, 5α-pregnanediol and 5β-pregnanediol. 5β-pregnanediol represents the majority end point of endogenous progesterone metabolism and appears to have little activity within the body, while 5α-pregnanediol, the lesser metabolite of PDL, can cross the blood brain barrier and may partially agonize GABA-A receptors.

Metabolites of progesterone are measured in urine, including 5b-pregnanediol and 5a-pregnanediol. 5b-pregnanediol is inactive in the body but is the major metabolite of progesterone. 5a-pregnanediol is often a metabolite of more interest, as it can cross the blood brain barrier and up-regulate GABA activity and is considered neuroprotective to the brain. Both taken together represent the major metabolic end points for progesterone and can be used to represent total progesterone production.

The Etiocholanolone/Androsterone (E/A) Ratio assesses androgen metabolism by comparing the enzymatic activity of 5β-reductase/5α-reductase.

5B-THB is a terminal metabolite of corticosterone. This metabolite in combination with other terminal metabolites can be used to estimate metabolism of corticosterone. While research in elevations or low levels of single terminal metabolites is limited, assessing metabolism may provide valuable information about enzyme activity.

5a-Tetrahydrocorticosterone (5a-THB) is a lesser-known metabolite of cortisol, and its measurement on a HUMAP panel can provide valuable insights, particularly for pre-menopausal females.

5a-THB is a part of the complex hormonal interplay within the body and serves as an indicator of not just adrenal function but also of the body's overall response to stress and metabolic processes.

5A-THF is a terminal metabolite of cortisol metabolized via 5-alpha reductase. This metabolite along with the other terminal metabolites can be used to determine metabolized cortisol.

5α-Tetrahydrocortisol (5α-THF), a crucial adrenal metabolite, is an essential marker in the Comprehensive 24-Hour Urine Steroid Hormone Profile Test, particularly for evaluating male adrenal function and stress response. 5α-THF, a metabolite derived from cortisol, the body's primary stress hormone, provides a key insight into cortisol metabolism and adrenal gland health in men. The 24-hour urine collection method for assessing 5α-THF levels offers a comprehensive overview of daily cortisol activity, which is vital for understanding the body’s response to stress and overall adrenal function.