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White Blood Cell Differential Test

Polymorphs

Optimal Result: 40 - 75 %.

Polymorphonuclear (PMN) cells refer to the group of white cells known as granulocytes. The three types of granulocytes are:

Neutrophils

Basophils

Eosinophils

What does it mean if your Polymorphs result is too high?

When "POLYS," or polymorphonuclear leukocytes, are elevated on a hematology test panel, it generally indicates an increase in neutrophils. Neutrophils are a type of white blood cell essential for fighting infections and are typically the first responders to bacterial infections and inflammatory conditions. Elevated levels of POLYS can suggest that the body is responding to an infection, inflammation, stress, or other factors such as trauma or certain medications.

Possible Causes of Elevated POLYS:

  1. Bacterial Infections: The most common reason for elevated POLYS is an active bacterial infection. The body produces more neutrophils to help combat the infection and protect against further spread.

  2. Inflammatory Conditions: Autoimmune diseases like rheumatoid arthritis or inflammatory conditions such as inflammatory bowel disease can also elevate POLYS as part of the immune response.

  3. Stress and Trauma: Physical stress, surgery, trauma, or intense exercise can sometimes lead to a temporary increase in POLYS.

  4. Medications: Some medications, including corticosteroids, may increase neutrophil levels by causing them to be released from storage in the bone marrow.

  5. Chronic Health Conditions: Conditions like chronic kidney disease, certain cancers, and other chronic inflammatory states can also elevate POLYS.

Interpretation and Next Steps:

If POLYS are elevated, it’s important to consider the full clinical picture, including symptoms, medical history, and other test results. Often, an elevated POLYS count is temporary and resolves once the underlying cause is treated. However, if levels remain high without an obvious cause, further investigation may be needed to rule out underlying infections, inflammatory diseases, or other health issues.

Your healthcare provider can guide you on the significance of this finding in your specific context and whether any additional tests or treatments are needed.

What does it mean if your Polymorphs result is too low?

Granulocytopenia is an abnormally low concentration of granulocytes in the blood. This condition reduces the body's resistance to many infections. Closely related terms include agranulocytosis (etymologically, "no granulocytes at all"; clinically, granulocyte levels less than 5% of normal) and neutropenia (deficiency of neutrophil granulocytes).

Frequently asked questions

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