Borrelia burgdorferi p83-93 IgG – Tickborne Diseases Panel (Vibrant America)
What is it?
The Borrelia burgdorferi p83-93 IgG marker detects the presence of IgG antibodies against a specific protein (p83-93) found in Borrelia burgdorferi, the bacterium that causes Lyme disease. This protein is associated with the late stages of Lyme disease and is considered highly specific to Borrelia.
What does p83-93 mean?
The numbers “p83-93” refer to a protein with a molecular weight of 83 to 93 kilodaltons, which is strongly immunogenic. It is typically expressed during later phases of infection, and the body produces IgG antibodies in response.
Why is this marker important?
A positive p83-93 IgG result may indicate a long-standing or late-stage infection with Borrelia burgdorferi. IgG antibodies generally take weeks to develop, so this marker is not used to detect early infection but rather to assess chronic or past exposure.
Elevated or positive IgG p83-93 may suggest:
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Late-stage Lyme disease, especially with neurological, cardiac, or joint symptoms
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Persistent immune response following prior infection
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Previous Borrelia exposure, even if current symptoms are not present
Limitations and context:
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A positive result should be interpreted alongside clinical symptoms and other Borrelia-specific markers (such as p41, p18, OspC)
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False positives can occur, though p83-93 is considered relatively specific to Lyme disease
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A full clinical evaluation and possibly confirmatory testing (Western blot, PCR, or C6 peptide ELISA) are recommended
Who should be tested?
This marker is most useful for individuals who:
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Have unexplained chronic fatigue, joint pain, or neurological symptoms
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Suspect long-term Lyme disease
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Have been exposed to tick-endemic areas and have persistent health issues
Clinical note:
A positive p83-93 IgG result alone does not confirm active infection—it reflects immune memory. It must be interpreted in the broader clinical context.
Borrelia burgdorferi p83-93 (IgG)
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