The 2-Methoxy / 2-OH Balance is a measure used to assess the balance between two important forms of estrogen metabolites in the body. Estrogen, a hormone crucial for various bodily functions, undergoes a process called metabolism, where it is broken down into different metabolites. Among these metabolites, 2-methoxyestrone (2-Methoxy) and 2-hydroxyestrone (2-OH) are significant. The balance between these two metabolites is essential for overall health, as an imbalance can potentially indicate increased risk for certain health conditions, including hormone-related cancers and cardiovascular diseases. Specifically, a higher ratio of 2-Methoxy to 2-OH is generally considered favorable, as it suggests a more favorable estrogen metabolism pattern associated with lower cancer risk. However, the interpretation of this ratio should be done in the context of individual health and other factors.
Important Note: If Estrogen metabolite levels are very low, the reproducibility of the test is not as ideal, so calculated ratios (for the methylation-activity index and phase I estrogen metabolism ratios) are more approximate, less certain, and may not be reported.
Your medical lab tests hold vital information about your health. Our tools help you understand what's going on and how to take action.
$15 $5.99/first month
Cancel or upgrade anytime
An elevated 2-Methoxy / 2-Hydroxy balance can have several implications related to estrogen metabolism. Here's a breakdown of what it might mean:
Estrogen Metabolism: Estrogens are metabolized in the body through various pathways, leading to the production of different metabolites. Two of the key metabolites are 2-hydroxyestrone (2-OH) and 2-methoxyestrone (2-MeO). The balance between these metabolites can provide insights into how estrogen is being processed in the body.
Methylation Activity: The conversion of 2-hydroxyestrone to 2-methoxyestrone involves a process called methylation, which is facilitated by the enzyme catechol-O-methyltransferase (COMT). An elevated 2-Methoxy / 2-Hydroxy ratio suggests that there is high methylation activity. This can indicate efficient processing of estrogen through this pathway.
Protective Metabolite Production: 2-methoxyestrone is considered a protective estrogen metabolite with anti-proliferative properties, meaning it is less likely to contribute to estrogen-driven conditions such as certain cancers. An elevated balance might suggest that the body is producing a higher amount of this protective metabolite, which could be viewed positively in terms of cancer risk reduction.
Genetic Factors: Genetic variations in the COMT enzyme can influence this balance. Individuals with certain genetic polymorphisms may have more active COMT, leading to higher levels of methylated metabolites.
Nutritional and Lifestyle Factors: Nutrient status (such as levels of B vitamins, magnesium, and SAMe), as well as lifestyle factors (like stress and diet), can affect methylation processes and thus influence the 2-Methoxy / 2-Hydroxy balance.
Implications for Health:
→ Cancer Risk: Elevated levels of 2-methoxyestrone may be protective against estrogen-sensitive cancers (such as breast cancer) because it suggests efficient methylation and detoxification of potentially harmful estrogen metabolites.
→ Hormonal Balance: It might also reflect an overall healthy hormonal balance and metabolism.
→ Liver Function: Efficient methylation also points to good liver function, as the liver plays a central role in hormone metabolism and detoxification.
Considerations:
While an elevated 2-Methoxy / 2-Hydroxy balance can be seen as positive in many contexts, it is essential to consider it alongside other clinical findings and symptoms. Consulting with a healthcare provider is crucial for interpreting these results in the context of the individual’s overall health, medical history, and specific health concerns.
If you have specific symptoms or conditions that you're concerned about, it would be beneficial to discuss these test results with your healthcare provider to get a comprehensive understanding of what they mean for your health.
Important Note: If Estrogen metabolite levels are very low, the reproducibility of the test is not as ideal, so calculated ratios (for the methylation-activity index and phase I estrogen metabolism ratios) are more approximate, less certain, and may not be reported.
Anthony
Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
A low 2-Methoxy / 2-Hydroxyestrone (2-Methoxy / 2-OH) balance ratio can provide insights into estrogen metabolism and potential health implications. Here's what it signifies:
Estrogen Metabolism:
- 2-Hydroxyestrone (2-OH): This is considered a "good" estrogen metabolite because it has weaker estrogenic activity and is less likely to promote estrogen-dependent cancers.
- 2-Methoxyestrone (2-Methoxy): This is a further metabolized form of 2-OH and is considered even more protective against estrogen-related cancers.
Low 2-Methoxy / 2-OH Ratio:
Impaired Methylation:
- A low ratio suggests that the conversion of 2-OH to 2-Methoxy is inefficient, which may indicate impaired methylation processes. Methylation is crucial for various biochemical processes, including detoxification and DNA synthesis.
- Factors affecting methylation include deficiencies in nutrients like folate, vitamin B6, and vitamin B12, and genetic polymorphisms (e.g., MTHFR mutations).
Increased Risk of Estrogen-Related Cancers:
- With a higher proportion of 2-OH and a lower proportion of 2-Methoxy, the protective effect of the latter is reduced. This may lead to a relatively higher risk of developing estrogen-related cancers (e.g., breast cancer).
Hormonal Imbalance:
- This imbalance might suggest a need for closer monitoring of overall hormonal health. It can be part of a broader pattern of estrogen dominance, which could contribute to symptoms like breast tenderness, heavy periods, or mood swings.
Detoxification Pathways:
- The liver's ability to effectively detoxify estrogen may be compromised, indicating that supporting liver function through diet, lifestyle, and potentially supplementation could be beneficial.
Clinical Context:
Symptoms and Health History:
- It's important to consider this ratio within the broader context of the individual's symptoms, medical history, and other hormone levels. A comprehensive hormonal panel and assessment by a healthcare provider specializing in hormone health are recommended.
Intervention and Monitoring:
- Interventions may include dietary adjustments (e.g., increasing cruciferous vegetables), lifestyle changes (e.g., reducing alcohol intake, managing stress), and supplements that support methylation (e.g., methylated B vitamins).
Conclusion:
A low 2-Methoxy / 2-OH balance ratio indicates that the body may not be effectively converting 2-hydroxyestrone to its more protective form, 2-methoxyestrone. This could signal potential issues with methylation, an increased risk of estrogen-related cancers, and a need for strategies to support estrogen detoxification and balance. A healthcare provider can offer personalized recommendations based on a thorough evaluation.
Important Note: If Estrogen metabolite levels are very low, the reproducibility of the test is not as ideal, so calculated ratios (for the methylation-activity index and phase I estrogen metabolism ratios) are more approximate, less certain, and may not be reported.
Guiding our users for 10 years to promptly understand, track, and act on their laboratory results.
$15 $5.99/first month
Cancel your subscription at any time.
$250/once
full premium version
$45/month
track your clients’ labs
Cancel your subscription at any time.
Guiding our users for 10 years to promptly understand, track, and act on their laboratory results.
Personal plans
track personal results
Professional Plan
track multiple client's results
$15 $5.99/first month
$250/once
own it for life
$45/month
for health professionals
Complete Plan
Unlimited Plan
$15 $5.99
$250 full version
Are you a health professional?
Level up your lab report analysis with our Pro plan, built for health practitioners like you.
Health Business Account
$45/month
Cancel your subscription at any time.
Unlock additional Pro plans when you sign up.
Anthony
Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
Healthmatters is a highly-personalized health dashboard.
Instead of searching for your lab results in different places or tracking them down from different providers, Healthmatters houses, organizes, and interprets them all in one central location.
With a Healthmatters account, you can dive into the details of each biomarker and gain insights into the meaning behind your medical test data, anytime, anywhere.
For our professional users, Healthmatters provides intuitive tools that not only streamline analysis but also save valuable time when delving into your client's lab report history.
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you’re on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our special data entry service makes it easy to add your results to your private dashboard. Just attach an image or a file of your lab test results, and our skilled data entry team will do the work for you. It's all done by humans, ensuring that your data is entered accurately and with personal care for each client.
Depending on your account, the data entry service can be included for free or come at an additional cost of $15 per report.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
The Unlimited plan is a one-time purchase for $250, and it covers your account for a lifetime with no additional payments.
For the Complete plan, the cost is $15 per month. You have the flexibility to cancel it anytime through your account settings, ensuring no further payments. To avoid charges, remember to cancel at least a day before the renewal date. Once canceled, the subscription remains active until the end of the current billing cycle.
Additionally, you can upgrade to the yearly Advanced plan from within your account. The annual cost is $79, and it comes with a data entry service for five reports.
You can always upgrade to a lifetime version with a prorated price from a monthly or yearly subscription.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We’ve crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewExplore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
