Anti-Saccharomyces cerevisiae antibody (ASCA) IgG is an immune protein directed against a sugar in the cell wall of common yeast — not against your own tissue. It appears far more often in people with Crohn's disease than in ulcerative colitis, so it's used alongside pANCA and other markers to support the differential diagnosis of inflammatory bowel disease. On its own it can't diagnose or rule out Crohn's, but a positive result — especially paired with a positive ASCA IgA — raises the likelihood of Crohn's and, in people already diagnosed, is associated with earlier onset and a more complicated disease course.

Note on the equivocal range: results that fall between the negative and positive cutoffs are reported as equivocal — neither clearly negative nor positive. An equivocal ASCA IgG usually calls for correlation with the other markers and, sometimes, repeat testing.

Saccharomyces cerevisae, baker’s yeast, contains Chl1p, a putative helicase with human homologs (antiSaccharamyces cerevisae antibody – ASCA). It is required for DNA repair, recombination, transcriptional silencing and aging. Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies produced against antigens in the cytoplasm of neutrophil granulocytes and monocytes.

Known Cross-Reactions: Mannan, enteric bacterial antigens

Antibodies Appear: Crohn’s disease, Sjögren’s syndrome

Ascaris lumbricoides, an intestinal roundworm, is one of the most common helminthic human infections worldwide.

Ascaris lumbricoides is the largest intestinal nematode of man. The female worms are larger than the males and can measure 40 cm in length and 6 mm in diameter. They are white or pink and are tapered at both ends. 

Ascaris is a worm that infects the small intestine, but its life cycle includes migration through the circulation to the heart and lungs, and into the oropharynx. Infection is acquired through the ingestion of embryonated eggs in contaminated soil or water. Ascariasis is the most prevalent intestinal helminth infection in the world; current estimates suggest that more than 1 billion persons are infected. In the US, infection is more common in rural parts of the southeast.

Most individuals have no noticeable symptoms. Migrating larvae may produce “verminous pneumonia”. However, heavy infection, especially in children, may produce abdominal cramps, and a mass of tangled worms may cause intestinal obstruction. Aberrant migration of individual adult worms occasionally leads to obstructions resulting in cholangitis, cholecystitis, liver abscess, pancreatitis, appendicitis, or peritonitis.

Ascorbic Acid is a natural water-soluble vitamin (Vitamin C). Ascorbic acid is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen in fibrous tissue, teeth, bones, connective tissue, skin, and capillaries.

Ascorbic Acid is a natural water-soluble vitamin (Vitamin C). Ascorbic acid is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen in fibrous tissue, teeth, bones, connective tissue, skin, and capillaries.

Ascorbic Acid is a natural water-soluble vitamin (Vitamin C). Ascorbic acid is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen in fibrous tissue, teeth, bones, connective tissue, skin, and capillaries.

Ascorbic Acid is a natural water-soluble vitamin (Vitamin C). Ascorbic acid is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen in fibrous tissue, teeth, bones, connective tissue, skin, and capillaries.

Ascorbic Acid is a natural water-soluble vitamin (Vitamin C). Ascorbic acid is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen in fibrous tissue, teeth, bones, connective tissue, skin, and capillaries.

Ascorbic Acid is a natural water-soluble vitamin (Vitamin C). Ascorbic acid is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen in fibrous tissue, teeth, bones, connective tissue, skin, and capillaries.

GM1 is exposed at the surface of spinal motor neurons, and in the peripheral nerves, it is limited to the node and paranodal region. Low levels of antibodies can be found in normal individuals and in patients with certain autoimmune disorders, however, high titers may be helpful in the diagnosis of multifocal motor neuropathy with conduction block (MMNCB), and paraproteinenia including motor neuron disease and multifocal motor neuropathy.

Asialoganglioside is exposed at the surface of spinal motor neurons, and in the peripheral nerves, it is limited to the node and paranodal region. Low levels of antibodies can be found in normal individuals and in patients with certain autoimmune disorders, however, high titers may be helpful in the diagnosis of multifocal motor neuropathy with conduction block (MMNCB), and paraproteinenia including motor neuron disease and multifocal motor neuropathy.

Asparagine is a dietarily dispensable amino acid synthesized from aspartate and glutamine. Asparagine has three major functions:

1) incorporation into amino acid sequences of proteins;

2) storage form for aspartate (is a required precursor for synthesis of DNA, RNA and ATP); and

3) source of amino groups for production of other dispensable amino acids via trasaminases.