Diabetic Ketoacidosis

Diabetic ketoacidosis (DKA) is a life-threatening metabolic emergency that occurs when insulin levels are too low for the body to use glucose properly, leading to excess ketone production and a high anion gap metabolic acidosis. It is often first recognized on blood tests showing high glucose, elevated ketones, and low bicarbonate, sometimes before symptoms become severe.

DKA develops when insulin deficiency prevents cells from using glucose for energy. In response, the body breaks down fat, producing ketones such as beta-hydroxybutyrate and acetoacetate. As these ketones accumulate, they cause metabolic acidosis and disrupt fluid and electrolyte balance.

What Causes Diabetic Ketoacidosis?

The most common triggers of DKA are infection, missed insulin doses, and new-onset diabetes. Additional contributing factors include:

• Missed or insufficient insulin therapy
• Infections (e.g., pneumonia, urinary tract infections)
• New-onset diabetes
• Acute illness or major stress (such as surgery or trauma)
• Medications (e.g., corticosteroids, SGLT2 inhibitors, including euglycaemic DKA)

These factors either increase insulin demand or reduce insulin availability, leading to uncontrolled ketone production.

Key Biomarkers & Tests

DKA is diagnosed and monitored through blood and urine testing:

• Glucose (typically elevated, often >250 mg/dL / 13.9 mmol/L)
• Blood ketones (especially beta-hydroxybutyrate)
• Anion gap (elevated)
• Serum bicarbonate (low levels)
• Blood pH (metabolic acidosis)
• Electrolytes (especially potassium)
• Creatinine (to assess dehydration and kidney function)

An elevated anion gap reflects the buildup of ketones. Low bicarbonate and low pH confirm metabolic acidosis.

Potassium levels may be high, normal, or low on initial testing, but total body potassium is typically depleted due to urinary losses—making careful monitoring and replacement essential during treatment.

Note: Urine ketone tests may underestimate severity because they mainly detect acetoacetate, while beta-hydroxybutyrate—best measured in blood—is the predominant ketone in DKA.

Signs and Symptoms of Diabetic Ketoacidosis

Symptoms of DKA often develop over hours to days and may include:

• Excessive thirst and frequent urination
• Nausea and vomiting
• Abdominal pain
• Rapid, deep breathing (Kussmaul respirations)
• Fruity-scented breath
• Fatigue and weakness
• Confusion or decreased consciousness in severe cases

These symptoms reflect dehydration, acidosis, and electrolyte imbalance.

Complications

If untreated, DKA can lead to:

• Severe dehydration
• Electrolyte disturbances (especially potassium shifts affecting heart rhythm)
• Cerebral edema (rare but serious, especially in children)
• Acute kidney injury
• Shock or death in severe cases

Many of these complications can be detected early through lab monitoring—worsening acidosis, rising ketones, and electrolyte abnormalities are key warning signs.

Treatment & Management

DKA requires urgent medical treatment and is typically managed in a hospital setting:

• Intravenous fluids to correct dehydration
• Insulin therapy to stop ketone production and lower glucose
• Electrolyte replacement (especially potassium)
• Treatment of underlying triggers (e.g., infection)
• Close monitoring with repeat labs (glucose, ketones, electrolytes, blood gases)

Insulin is a central component of treatment and distinguishes DKA from other forms of ketoacidosis.

Diabetic vs Alcoholic Ketoacidosis

Distinguishing DKA from alcoholic ketoacidosis is important:

• DKA: Markedly elevated glucose, absolute or relative insulin deficiency, typically in individuals with diabetes
• Alcoholic ketoacidosis: Normal or mildly elevated glucose, associated with heavy alcohol use and poor intake, usually without known diabetes

This distinction is critical for selecting the correct treatment approach.

For people with diabetes, tracking glucose, ketones, and bicarbonate trends over time can help identify early warning signs before a full DKA episode develops.