Xanthurenic Acid

Optimal Result: 0 - 0.96 mmol/mol creatinine.

3200 Metabolomix+ - FMV Urine Genova Diagnostics

From Healthmatters.io Team

Lab Results Explained and Tracked

Xanthurenic acid is produced as part of the kynurenine pathway of tryptophan catabolism, along with kynurenic and quinolinic acid.

References:

- Brown R, Thornton MJ, Price J. The effect of vitamin supplementation on the urinary excretion of tryptophan metabolites by pregnant women. J Clin Invest. 1961;40(4):617- 623.

- Ciorba MA. Kynurenine pathway metabolites: relevant to vitamin B-6 deficiency and beyond. Am J Clin Nutri. 2013;98(4):863-864.

- Payne IR, Walsh EM, Whittenburg EJR. Relationship of dietary tryptophan and niacin to tryptophan metabolism in schizophrenics and nonschizophrenics. Am J Clin Nutr. 1974;27(6):565-571.

- Linkswiler H. Biochemical and Physiological Changes in Vitamin B6 Deficiency. Am J Clin Nutr. 1967;20(6):547-557.

- Luhby AL, Brin M, Gordon M, Davis P, Murphy M, Spiegel H. Vitamin B6 metabolism in users of oral contraceptive agents. I. Abnormal urinary xanthurenic acid excretion and its correction by pyridoxine. Am J Clin Nutr. 1971;24(6):684-693.

- Chiang EP, Selhub J, Bagley PJ, Dallal G, Roubenoff R. Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis. Arthr Res Ther. 2005;7(6):R1404-1411.

- Yess N, Price JM, Brown RR, Swan PB, Linkswiler H. Vitamin B6 Depletion in Man: Urinary Excretion of Tryptophan Metabolites. J Nutr. 1964;84(3):229-236.

Lab Results Explained and Tracked

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What does it mean if your Xanthurenic Acid result is too high?

Because this pathway is heavily dependent on vitamin B6, elevations of xanthurenic acid can reflect a functional need for vitamin B6.

Kynurenine pathway metabolites may also become elevated when there are needs for vitamin B3.

Elevations in urinary xanthurenic acid are seen with increased intake of tryptophan, and in high estrogen states. Pregnancy and oral contraceptive use is associated with elevated levels of urinary xanthurenic acid where a functional nutrient need for B-vitamins is pronounced.

Abnormalities in the kynurenine pathway have been associated with many clinical conditions including immune suppression, cancer, and inflammatory conditions. Administration of vitamin B6 can decrease xanthurenic acid excretion.

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Xanthurenic Acid

All Your Lab Results. One Simple Dashboard.

What does it mean if your Xanthurenic Acid result is too high?

All Your Lab Results. One Simple Dashboard.

Import, Track, and Share Your Lab Results Easily

Import, Track, and Share Your Lab Results

Article Review & Sources

Bring All Your Lab Results Together — In One Place

Gather Your Lab History — and Finally Make Sense of It

Finally, Your Lab Results Organized and Clear

Advanced Plan

Unlimited Account

Pro Monthly

What's included in a Healthmatters membership

Import Lab Results from Any Source

See Your Health Timeline

Understand What Your Results Mean

Enter Your Lab Reports Yourself — Always Free Enter Your Lab Reports — Always Free

Visualize Your Results

Export Your Complete Lab History in a Single File Export Your Complete Lab History

Comprehensive Data Entry Service for Your Reports Data Entry Service for Your Reports

Securely Share With Anyone You Trust

Let Your Lab Results Tell the Full Story

Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.

Bring all your results together to compare, track progress, export your history, and share securely.

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All Your Lab Results.
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