Vit B7 Biotin

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check icon Optimal Result: 10.51 - 29.69 Healthy Relative Abundance IQR (%).

Biotin is a water soluble vitamin necessary for growth, development, and energy production and may support healthy hair, skin, and nails. Biotin also acts as a cofactor for 5 carboxylases and plays an important role in balancing immune responses. Biotin is synthesized from tryptophan by intestinal bacteria and can also be found in foods such as meat, beans, milk, and cereal grains. Interestingly, when the human body is deficient in biotin, intestinal cells can actually increase the biotin uptake process, allowing the human host to feed off of biotin produced by the gut microbiome. Bacteroides fragilis, Prevotella copri, and several members of the Proteobacteria phylum possess a vitamin B7 biosynthesis pathway. In contrast, species belonging to Prevotella, Bifidobacterium, Clostridium, Ruminococcus, Faecalibacterium, and Lactobacillus are unable to produce biotin yet need it for survival, suggesting that these bacteria may compete with the host for biotin utilization.

Free biotin in the gut can change the composition of the gut microbiome and is linked to the overgrowth of Lactobacillus murinus and unfavorable outcomes. Furthermore, Bifidobacterium longum produces a B7 precursor that enhances vitamin B7 production by other intestinal bacteria. Gut bacteria only contribute about 5% of the daily recommended intake of B7 for adults, so it is important to ensure adequate biotin intake from the diet and/or supplementation.

What does it mean if your Vit B7 Biotin result is too high?

Elevated levels of Vitamin B7 (Biotin) on a BiomeFx test generally do not signify a health concern. Here are the key points:

  1. Potential causes of elevation:
    • Consumption of biotin-rich foods
    • Taking supplements with high amounts of biotin
    • Recent dietary intake or supplementation
  2. Safety profile:
    • High biotin levels have not been associated with adverse effects in humans or animals, even with daily doses up to 200 mg orally and up to 20 mg intravenously.
    • No observable toxicities have been reported with high intakes from food sources or supplements.
  3. Excretion of excess:
    • Biotin is water-soluble, and excess amounts are typically excreted in the urine.
  4. Gut microbiome effects:
    • Free biotin in the gut can change the composition of the gut microbiome.
    • It has been linked to the overgrowth of certain bacteria like Lactobacillus murinus.
  5. Interpretation considerations:
    • Elevated levels may simply reflect recent intake rather than a health issue.

While elevated biotin levels are generally not a cause for concern, it's important to note that extremely high levels could potentially affect the gut microbiome composition. As with any test result, it's advisable to consult with a healthcare professional for personalized interpretation and advice, especially if there are concerns about excessive supplementation or potential impacts on gut health.

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What does it mean if your Vit B7 Biotin result is too low?

When biotin levels appear low on a BiomeFX panel, it indicates a potential deficiency. This could impact various bodily functions and the balance of the gut microbiome. If you notice low biotin levels, consider discussing dietary changes or supplementation with a healthcare professional.

Biotin, also known as vitamin B7, is a water-soluble vitamin essential for growth, development, and energy production. It supports healthy hair, skin, and nails, and plays a vital role in balancing immune responses. Importantly, biotin acts as a cofactor for five carboxylases - enzymes crucial for various metabolic processes in the body.

Biotin is found in foods such as meat, beans, milk, and cereal grains. Interestingly, it can also be synthesized from tryptophan by certain intestinal bacteria. When the human body is deficient in biotin, intestinal cells can increase their biotin uptake, allowing the host to utilize biotin produced by the gut microbiome.

The relationship between biotin and gut bacteria is complex:

  1. Biotin Producers: Some bacteria, including Bacteroides fragilis, Prevotella copri, and several members of the Proteobacteria group, can produce biotin.
  2. Biotin Consumers: Other bacteria, such as certain species of Prevotella, Bifidobacterium, Clostridium, Ruminococcus, Faecalibacterium, and Lactobacillus, require biotin but cannot produce it. This creates competition between these bacteria and the host for biotin utilization.
  3. Microbiome Influence: Free biotin in the gut can alter the microbiome composition. For example, it's linked to the overgrowth of Lactobacillus murinus, which may have unfavorable outcomes.
  4. Cooperative Production: Bifidobacterium longum produces a biotin precursor that enhances vitamin B7 production by other intestinal bacteria.

While gut bacteria contribute to biotin production, they only provide about 5% of the daily recommended intake for adults. Therefore, ensuring adequate biotin intake from diet and/or supplementation is crucial for maintaining overall health and a balanced gut microbiome.

Biotin plays a significant role in both overall health and gut microbiome balance. While some gut bacteria can produce biotin, dietary sources remain crucial. Understanding the interplay between biotin, gut bacteria, and host health can help in maintaining optimal wellness and a balanced microbiome.

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