TMA (Trimethylamine) and TMAO (trimethylamine N-oxide) are key biomarkers in understanding the connection between diet, gut microbiota and heart health.
TMA is a small molecule produced by the gut microbiota when we digest certain dietary components like choline, lecithin and L-carnitine which are found in red meat, eggs and dairy.
Once TMA is formed in the gut it’s absorbed into the blood and transported to the liver where it’s converted to TMAO by the enzyme flavin-containing monooxygenase 3 (FMO3).
High levels of TMAO have been linked to increased risk of cardiovascular disease (CVD) like atherosclerosis, heart attacks and strokes. TMAO is thought to contribute to atherosclerosis by promoting cholesterol deposition in the artery walls and inhibiting reverse cholesterol transport. TMAO can also influence platelet function and increase the risk of thrombosis. Research has shown TMA and TMAO can be used as biomarkers of dietary intake and microbiota activity, linking specific dietary patterns to CVD risk. So measuring TMA and TMAO in the blood can be a useful tool in clinical settings to predict and manage CVD risk. Reducing TMAO production through dietary changes such as reducing TMA precursors or altering gut microbiota through probiotics or other interventions has been suggested as a way to mitigate CVD risk associated with high TMAO levels.
Keeping track of your medical data and laboratory results while understanding what they mean empowers positive health outcomes.
Keeping track of your medical data and lab results while understanding what they mean empowers positive health outcomes.
Save 10% off any plan with promo-code:
HEALTH10
HIGH TMA LEVELS AND NORMAL TMAO LEVELS:
If TMA levels are high but TMAO levels are normal, it could indicate a few different scenarios related to metabolism, liver function, and gut microbiota activity. Here are some potential interpretations:
Liver Function and Enzyme Activity: The liver enzyme flavin-containing monooxygenase 3 (FMO3) is responsible for converting TMA to TMAO. If TMA is high but TMAO is normal, it may suggest that there is a reduced activity or partial deficiency of FMO3. This could be due to genetic variations in the FMO3 gene, liver dysfunction, or other factors affecting enzyme activity.
Gut Microbiota Composition: The composition of gut microbiota plays a crucial role in the production of TMA from dietary precursors. High levels of TMA could indicate a gut microbiota composition that is highly efficient at producing TMA from dietary sources such as choline, lecithin, and L-carnitine. However, if TMAO levels remain normal, it suggests that the conversion of TMA to TMAO in the liver is proceeding at a typical rate, or that the body is effectively managing the excretion or metabolism of TMAO.
Dietary Factors: High TMA levels might reflect a diet high in TMA precursors like red meat, eggs, and dairy. Normal TMAO levels could suggest that, despite high precursor intake, the body's conversion mechanisms are working adequately, or dietary patterns are modulating the conversion rates effectively.
Health Implications: Elevated TMA levels with normal TMAO levels might have different health implications compared to elevated TMAO levels. While high TMAO is strongly associated with cardiovascular risk, the direct implications of high TMA alone are less clear. However, it might still indicate an underlying metabolic or microbiota imbalance that could have other health consequences or predispose an individual to certain conditions if not addressed.
Diagnostic Considerations: Clinically, this scenario would prompt further investigation to understand the underlying causes. This might include assessing liver function tests, genetic testing for FMO3 activity, detailed dietary assessment, and potentially exploring the composition and activity of gut microbiota through advanced microbiome analysis.
In summary, high TMA with normal TMAO levels could point to issues with enzyme activity in the liver, specific dietary habits, or a particular gut microbiota profile. It would require a comprehensive approach to diagnose the underlying cause and address any potential health implications.
-------------------------
Treating elevated TMA (trimethylamine) levels when TMAO (trimethylamine N-oxide) levels are normal involves addressing the sources of TMA production and modifying factors that influence gut microbiota activity. Here are several strategies to manage elevated TMA levels:
Dietary Modifications
Gut Microbiota Modulation
Pharmacological Interventions
Lifestyle Changes
Monitoring and Regular Check-Ups
By focusing on these strategies, it is possible to manage elevated TMA levels effectively while maintaining normal TMAO levels, thereby reducing the risk of potential adverse health effects.
HIGH TMA LEVELS AND HIGH TMAO LEVELS:
If both TMA (trimethylamine) and TMAO (trimethylamine N-oxide) levels are high, it can provide significant insights into a person's health status, particularly regarding cardiovascular health and metabolic processes. Elevated TMA levels indicate increased production of this compound by gut microbiota, typically due to a diet rich in TMA precursors like choline, lecithin, and L-carnitine, found in foods such as red meat, eggs, and dairy products. When both TMA and TMAO are high, it suggests not only high production of TMA by gut bacteria but also efficient conversion of TMA to TMAO in the liver, which is mediated by the enzyme flavin-containing monooxygenase 3 (FMO3).
High levels of TMAO are particularly concerning because they are associated with an increased risk of cardiovascular diseases (CVD). TMAO is implicated in promoting atherosclerosis by enhancing cholesterol deposition in arterial walls and impairing reverse cholesterol transport, which is the process of removing cholesterol from tissues and transporting it to the liver for excretion. Additionally, TMAO can affect platelet function, increasing the risk of thrombosis and related cardiovascular events like heart attacks and strokes.
The combination of high TMA and TMAO suggests a robust link between dietary habits, gut microbiota activity, and liver metabolic function, leading to an increased cardiovascular risk. It highlights the importance of dietary modifications to reduce the intake of TMA precursors and potentially using interventions to alter gut microbiota composition. These interventions may include the use of probiotics, prebiotics, or other dietary supplements aimed at reducing TMA production. Monitoring and managing these biomarker levels could be critical in preventing and treating cardiovascular diseases, emphasizing the need for integrated approaches that consider diet, gut health, and metabolic pathways.
Sign up
Sign up now and create your account. Use code HEALTH10 for a 10% discount on any plan. Don't miss out!
Organize
Bring all results from any laboratories to your account. You can enter your tests yourself, or we'll be happy to organize your files—whether in PDF, JPEG, CSV, or even screenshots.
Learn and improve
Once your information is stored in your account, dive into a wealth of insights about your results. If you have any more questions, we are here to answer them.
Guiding our user for 10 years to promptly understand, track, and act on their laboratory results.
$15/month
for personal lab results
Cancel your subscription at any time.
$250/once
full premium version
$45/month
track your clients’ labs
Cancel your subscription at any time.
Guiding our user for 10 years to promptly understand, track, and act on their laboratory results.
Personal plans
track personal results
Professional Plan
track multiple client's results
$15/month
for personal lab results
$250/once
own it for life
$45/month
for health professionals
Complete Plan
Unlimited Plan
$15 per month
$250 full version
Are you a health professional?
Level up your lab report analysis with our Pro plan, built for health practitioners like you.
Health Business Account
$45/month
Cancel your subscription at any time.
Unlock additional Pro plans when you sign up.
Unlock Your Health Journey with Healthmatters.io! Ever wished for a one-stop digital health haven for all your lab tests? Look no further! Healthmatters.io is your personalized health dashboard, bringing together test reports from any lab. Say goodbye to scattered results—organize and centralize your lab data effortlessly. Dive into the details of each biomarker and gain insights into the meaning behind your medical test data.
Join the community of thousands who've transformed the way they understand their lab results. Experience the joy of having all your lab data neatly organized, regardless of where or when the tests were done.
For our professional users, Healthmatters.io is a game-changer. Revel in the intuitive tools that not only streamline analysis but also save valuable time when delving into your client's lab report history. It's not just a dashboard; it's your gateway to a smarter, more informed health journey!
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we do talk about popular labs, we welcome reports from lots of other places too. It's as simple as this: if you can get a test done, you can upload it to Healthmatters. We can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
Still on the hunt for a specific biomarker? Just tell us, and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account!
There are two ways to add your test reports to your healthmatters.io account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you. We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our special data entry service makes it easy to add your results to your private dashboard. Just attach an image or a file of your lab test results, and our skilled data entry team will do the work for you. It's all done by humans, ensuring that your data is entered accurately and with personal care for each client.
Depending on your account, the data entry service can be included for free or come at an additional cost of $15 per report.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
The Unlimited plan is a one-time purchase for $250, and it covers your account for a lifetime with no additional payments.
For the Complete plan, the cost is $15 per month. You have the flexibility to cancel it anytime through your account settings, ensuring no further payments. To avoid charges, remember to cancel at least a day before the renewal date. Once canceled, the subscription remains active until the end of the current billing cycle.
Additionally, you can upgrade to the yearly Advanced plan from within your account. The annual cost is $79, and it comes with a data entry service for five reports.
You can always upgrade to a lifetime version with a prorated price from a monthly or yearly subscription.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Unlocking the insights from your lab tests has never been this intuitive! We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into a treasure trove of testing data.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewGet a quick grasp of your test reports in minutes! Explore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Experience the power of clear, organized data visualization with Healthmatters.io — your key to understanding and taking charge of your health journey!
Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional or business account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
1,5-Anhydroglucitol (1,5-AG), Intermediate Glycemic Control, 5-Methyltetrahydrofolate, AC/FC, Acylcarnitine, Adiponectin, Adiponectin (Boston Heart), Albumin/Creatinine Ratio, Random Urine, Anti-Thyroglobulin ab. (0-39), Anti-Thyroglobulin Antibody (Boston Heart), C-Peptide, LC/MS/MS, C-Peptide, Serum, C-Peptide, Ultrasensitive (Endocrine Sciences), Ceruloplasmin, Choline, CoQ10, Creatinine, Random Urine, Cyclic AMP, Plasma, Dihydrotestosterone (female), Dihydrotestosterone (male), Estimated Average Glucose (eAG), Free Androgen Index, Free testosterone, Free Testosterone (Male) in pmol/L, Free Testosterone (Male/Serum) in ng/ml, Free Testosterone, Direct (Female), Free Testosterone, Direct (Male), Free Testosterone, Percent (Female), Fructosamine, Glutamic Acid Decarboxylase, Glycated Hb (HbA1c), Glycated Serum Protein (GSP), Hemoglobin A1c (HbA1c), HOMA-B, HOMA-IR, HOMA-S, Homocysteine, Insulin (Fasting), Insulin Antibody, Insulin Resistance Score, Insulin, Free (Bioactive), Insulin, Intact, LC/MS/MS, Insulin-Like Growth Factor I (IGF-1), Iodine, Serum/Plasma, Nonesterified Fatty Acids (Free Fatty Acids), Pregnenolone, Proinsulin, Sex Horm Binding Glob, Serum (Male), Sex Hormone-Binding Globulin (SHBG), T7 Index, Testost., % Free+Weakly Bound, Testost., % Free+Weakly Bound (female), Testost., F+W Bound (female), Testost., Free, Calc (Female), Testosterone, Testosterone (Female/Child), Testosterone, bioavailable, Testosterone, bioavailable (male), Testosterone, Serum (Female), Thyroglobulin, Thyroglobulin Antibodies (0 - 1 IU/L), Thyrotropin Receptor Ab, Serum, Thyroxine-binding globulin, TBG, TMA, TMAO, TMAO (Trimethylamine N-oxide), Triiodothyronine, Serum, TSH Receptor Antibody (TBII), Zinc Transporter 8 (ZnT8) Antibody
