Epitestosterone is the biologically inactive 17-alphahydroxy epimer of testosterone. The interconversion between epitestosterone and testosterone is assumed to be very small in man, and only an insignificant fraction of testosterone (a maximum of 1-2%) is metabolized to epitestosterone in the body. Most healthy males exhibit a testosterone to epitestosterone ratio (T/E ratio) in urine of about 1:1.
Epi-testosterone is not androgenic like testosterone. It happens to be produced in about the same concentrations as testosterone (this is an approximate relationship). This can be helpful to assess testosterone therapy and rare cases where testosterone may have other complexities.
T/Epi-T
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