Streptozymes (NADase, DNase, streptokinase, streptolysin O, and hyaluronidase) are extracellular products, or exoantigens, of the streptococcus bacteria. Streptococcal antigens can bind to specific receptors on human cells and if found to pharyngeal or dermal epithelial cells, tissue penetration by the pathogen can occur. In this scenario, a throat culture will not detect the pathogen, while a serological antibody assay will. Streptozyme antibodies are markedly increased in PANDAS and OCD disorders, as well as rheumatic heart disorders and reactive arthritis.
Every lab result you’ve ever had, charted and explained.
Healthmatters is a tracker for your lab results. Upload a report from any lab, any country — every marker charted and explained.
Start with my report →All our content is backed by peer-reviewed studies, academic research, and trusted medical sources. We’re committed to accuracy and transparency — see our editorial policy for details.