Saliva Cortisone Total on a DUTCH (Dried Urine Test for Comprehensive Hormones) test measures the overall amount of cortisone present in saliva over a specified period, usually a day. Cortisone is a metabolite of cortisol, the body's primary stress hormone, produced by the adrenal glands. This measurement is crucial in assessing adrenal gland function and the body's stress response. Unlike single-point measurements, the total cortisone level provides a broader view of how cortisone levels fluctuate and are maintained throughout the day, offering insights into the health of the hypothalamic-pituitary-adrenal (HPA) axis and the body’s circadian rhythm. Abnormal total cortisone levels can indicate various conditions such as adrenal insufficiency, chronic stress, HPA axis dysregulation, or disturbances in circadian rhythms. It’s particularly important in understanding conditions related to stress, fatigue, and cortisol-cortisone balance disorders. When interpreted alongside other hormone levels and metabolites measured in the DUTCH test, Saliva Cortisone Total can help healthcare providers develop comprehensive diagnostic and treatment plans addressing adrenal health, stress management, and overall hormonal balance.
Every lab result you’ve ever had, charted and explained.
Healthmatters is a tracker for your lab results. Upload a report from any lab, any country — every marker charted and explained.
Start with my report →All our content is backed by peer-reviewed studies, academic research, and trusted medical sources. We’re committed to accuracy and transparency — see our editorial policy for details.