Pyruvate is a key player in energy metabolism, serving as a critical intermediate in the glycolytic pathway, where glucose is converted into pyruvate, and subsequently, pyruvate plays a central role in the Citric Acid Cycle (CAC), also known as the Krebs cycle. Elevated pyruvate levels on the panel can indicate a range of metabolic challenges and disruptions. High pyruvate levels may arise due to factors such as nutritional inhibitions affecting enzymes involved in pyruvate breakdown, the presence of low-activity enzyme variants inherited genetically, an abundance of precursor molecules like glucose and amino acids, or elevated levels of downstream products like lactate and citrate. These findings can signal potential issues with the entry of pyruvate into the CAC, affecting overall energy production and metabolism. Pyruvate's levels can also be influenced by various medical conditions, such as acidosis or chronic fatigue syndrome, which may further impact its metabolic functions. Additionally, pyruvate's interconversion with other metabolites, like lactate, can be compromised in cases of inadequate NAD+ synthesis or the presence of inherited enzyme variants with reduced activity, potentially necessitating vitamin B3 supplementation for improved NAD+ levels. Furthermore, understanding pyruvate's role in the context of environmental exposures, such as arsenic contamination and phthalate exposure, is crucial. Arsenic exposure can disrupt pyruvate metabolism and affect other organic acids, while phthalate exposure may inhibit the enzyme responsible for pyruvate-lactate interconversion. Overall, monitoring pyruvate levels on the US BioTek Organic Acids Panel aids healthcare practitioners in assessing metabolic health, identifying potential enzymatic deficiencies or imbalances, and guiding personalized interventions to optimize overall well-being.
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Elevated pyruvate levels can stem from multiple factors. These may include nutritional inhibition of the enzymes involved in its breakdown, the presence of inherited low-activity enzyme variations along the breakdown pathway, increased levels of precursors like glucose and amino acids, or elevated downstream products such as lactate and citrate. Elevated pyruvate levels can serve as an indicator of potential issues related to its entry into the Citric Acid Cycle (CAC), warranting a closer examination of citrate levels. Medical conditions like acidosis or chronic fatigue syndrome may also contribute to heightened pyruvate levels, potentially impeding the synthesis of essential compounds like carbohydrates, fatty acids, ketone bodies, alanine, and steroids. In cases where pyruvate is elevated while lactate is lower, challenges in interconverting these compounds may arise due to inadequate NAD+ synthesis or inherited low-activity enzyme variants, which may benefit from vitamin B3 supplementation. Additionally, if pyruvate is high and citrate is low, considering support for pyruvate's entry into the CAC with nutrients such as B1, B3, biotin, R-lipoic acid, magnesium, manganese, potassium, zinc, and glutathione is essential. It's worth noting that pyruvate's entry into the CAC may be hindered by arsenic or other toxic metal exposures, with arsenic exposure potentially elevating alpha-ketoglutarate and pyruvate while decreasing citrate and succinate levels. Arsenic contamination can be found in ground and well water, and it is sometimes added to factory-farmed poultry feed and used as a pesticide on fruits. Secondary lactic acidosis can be a contributing factor, associated with conditions like sleep apnea, blood infections, seizures, respiratory or cardiac insufficiency, and elevated dicarboxylic acid levels (cis-aconitate, isocitrate, succinate, malate, suberate, and adipate). Chronic fatigue may manifest with low levels of citrate, cis-aconitate, isocitrate, and malate. Additionally, phthalate exposures may hinder the enzyme responsible for pyruvate-lactate interconversion, prompting consideration of the US BioTek Environmental Pollutants Profile for assessing phthalate exposure.
Anthony
Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
Low levels of pyruvate may be indicative of several underlying factors. Such deficiencies can result from reduced levels of precursors like glucose and amino acids, nutritional enzyme inhibitions, or the presence of low-activity enzyme variants due to genetic inheritance. Low pyruvate levels can potentially highlight issues within the glycolysis pathway, fatty acid oxidation, or gluconeogenesis. Particularly, patients adhering to low-carbohydrate or ketogenic diets may derive pyruvate precursors from amino acids or fats instead of carbohydrates, and during extended fasting periods, most pyruvate may be channeled into gluconeogenesis rather than entering the Citric Acid Cycle. In such cases, it is crucial to review results in the Fatty Oxidation and Markers for Protein Metabolism sections to assess potential enzyme inhibitions related to pyruvate synthesis. If all three sections indicate low results, the patient may be fasting or following a low-calorie diet. To address low pyruvate levels, considerations should include supporting pyruvate production from carbohydrates or proteins, with nutrients like biotin, R-lipoic acid, B1, B3, B6, magnesium, potassium, zinc, and glutathione (antioxidants). Interestingly, high-lycopene tomato sauce consumption has been shown to increase lactate and pyruvate in human subjects. Furthermore, if pyruvate is low and lactate is elevated, it could suggest an inability to interconvert the two compounds, potentially due to insufficient NAD+ synthesis or inherited low-activity enzyme variants, which may benefit from vitamin B3 supplementation. For patients on high-fat or ketogenic diets, nutritional supports should be consideredv. Additionally, exposure to phthalate chemicals can hinder the enzyme responsible for pyruvate-lactate interconversion, prompting consideration of the US BioTek Environmental Pollutants Profile for assessing phthalate exposure.
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Anthony
Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
Healthmatters is a highly-personalized health dashboard.
Instead of searching for your lab results in different places or tracking them down from different providers, Healthmatters houses, organizes, and interprets them all in one central location.
With a Healthmatters account, you can dive into the details of each biomarker and gain insights into the meaning behind your medical test data, anytime, anywhere.
For our professional users, Healthmatters provides intuitive tools that not only streamline analysis but also save valuable time when delving into your client's lab report history.
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you’re on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our special data entry service makes it easy to add your results to your private dashboard. Just attach an image or a file of your lab test results, and our skilled data entry team will do the work for you. It's all done by humans, ensuring that your data is entered accurately and with personal care for each client.
Depending on your account, the data entry service can be included for free or come at an additional cost of $15 per report.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
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Additionally, you can upgrade to the yearly Advanced plan from within your account. The annual cost is $79, and it comes with a data entry service for five reports.
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Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We’ve crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewExplore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
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To learn more about Healthmatters Pro, please refer to the professional page.
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2-Hydroxyphenylacetate, 2-Methylhippurate, 3,4-Dimethylhippurate, 3-Indoleacetate, 3-Methylhippurate, 5-Hydroxyindoleacetate, Adipate, Alpha-Hydroxybutyrate, Alpha-Hydroxyisobutyrate, Alpha-Keto-Beta-Methylvalerate, Alpha-Ketoglutarate, Alpha-Ketoisocaproate, Alpha-Ketoisovalerate, Benzoate, Beta-Hydroxybutyrate, Beta-Hydroxyisovalerate, Cis-Aconitate, Citrate, Ethylmalonate, Fumarate, Hippurate, Homovanillate, Hydroxymethylglutarate, Isocitrate, Kynurenate, Lactate, Malate, Mandelate, Mandelate + Phenylglyoxylate, Methylmalonate, Methylsuccinate, Monoethyl Phthalate, Orotate, Para-Hydroxybenzoate, Para-Hydroxyphenylacetate, Para-Hydroxyphenyllactate, Phenylglyoxylate, Phthalate, Pyroglutamate, Pyruvate, Quinolinate, Suberate, Succinate, t,t-Muconic Acid, Tricarballylate, Vanilmandelate
