Progesterone is metabolized into numerous downstream compounds, but most immediately into pregnanediol and pregnanetriol. Urine levels of these metabolites tend to correlate with levels of serum progesterone, thus may be used to assess status of the hormone.
Progesterone is an active hormone and a prohormone in both men and women. It is completely metabolized into two primary molecules:
Pregnanediol and Pregnanetriol.
These metabolites are easily measured in the urine and together provide a robust analysis of progesterone status, which may be used to evaluate the need for, and monitoring of, progesterone hormone therapy.
Pregnanetriol (FMV urine, menopause)
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