Phosphoserine is a product of glycolysis and is formed by amino group transfer from glutamic acid to phosphohydroxypyruvic acid. Low levels of phosphoserine may be secondary to: vitamin B6 deficiency (as coenzyme pyridoxal phosphate for amino group transfer), low pyruvic acid, impaired glycolysis, or serine insufficiency where phosphoserine is consumed as a source for serine.
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