Phosphoserine is the phosphorylated ester of the amino acid serine. The addition of a phosphoryl group to an amino acid, or its removal, plays a role in cell signaling and metabolism. Phosphoserine is a byproduct of glycolysis and subsequent intermediate to then become serine. The enzyme that catalyzes this step, phosphoserine phosphatase, is magnesium dependent. This metabolite is not to be confused with a similar-sounding metabolite, phosphatidylserine; this is a common CNS supplement and essential for neuronal cell membranes.
References:
- Peeraer Y, Rabijns A, Collet JF, Van Schaftingen E, De Ranter C. How calcium inhibits the magnesium-dependent enzyme human phosphoserine phosphatase. Eur J Biochem. 2004;271(16):3421-3427.
- Kim HY, Huang BX, Spector AA. Phosphatidylserine in the brain: metabolism and function. Prog Lipid Res. 2014;56:1-18.
- Ramos RJ, Pras-Raves ML, Gerrits J, et al. Vitamin B6 is essential for serine de novo biosynthesis. J Inherit Metab Dis. 2017;40(6):883-891.
- Kang-Yoon SA, Kirksey A. Relation of short-term pyridoxineHCl supplementation to plasma vitamin B-6 vitamers and amino acid concentrations in young women. Am J Clin Nutr. 1992;55(4):865-872.
Phosphoserine
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