Phosphoserine

Elevated phosphoserine may be due to a functional lack of magnesium needed to catalyze the enzymatic conversion of phosphoserine to serine.

The enzyme which connects glycolysis to the formation of phosphoserine (phosphoserine aminotransferase) requires vitamin B6 as a cofactor. Lack of vitamin B6 can result in lower phosphoserine levels.

Supplementation with vitamin B6 was shown to alter plasma amino acids resulting in increased phosphoserine.

Phosphoserine is the phosphorylated ester of the amino acid serine. The addition of a phosphoryl group to an amino acid, or its removal, plays a role in cell signaling and metabolism. Phosphoserine is a byproduct of glycolysis and subsequent intermediate to then become serine. The enzyme that catalyzes this step, phosphoserine phosphatase, is magnesium dependent.

This metabolite is not to be confused with a similar-sounding metabolite, phosphatidylserine; this is a common CNS supplement and essential for neuronal cell membranes.