Parabens IgG+IgA

Optimal result: 0.2 – 1.5 ELISA Index

Clinical Significance: The detection of antibodies to Parabens bound to human protein in serum indicates a breakdown in immunological tolerance and induction of chemical intolerance. Parabens or their metabolites can bind to human tissue proteins and form neo-antigens. These new antigens are comprised of the haptenic chemical plus the tissue antigen. The formation of neo-antigens initiates an immune response which may result in antibody production against the chemical and the human tissue. Continued exposure to the chemical and the subsequent production of antibodies against various tissue antigens, may result in autoimmune reactivity. Persons with antibodies to Parabens bound to human protein in serum should avoid exposure to the substance.

Parabens are a class of chemical used as preservatives and have bactericidal and fungicidal properties. Parabens are used in many personal care and beauty products, and pharmaceuticals.

Parabens are man-made chemicals often used in small amounts as preservatives in cosmetics, pharmaceuticals, foods, and beverages. Common parabens are methylparaben, ethylparaben, propylparaben, and butylparaben. Often more than one paraben is used in a single product.

Parabens are a class of chemical used as preservatives and have bactericidal and fungicidal properties. Parabens are used in many personal care and beauty products, and pharmaceuticals.

Parabens are man-made chemicals often used in small amounts as preservatives in cosmetics, pharmaceuticals, foods, and beverages. Common parabens are methylparaben, ethylparaben, propylparaben, and butylparaben. Often more than one paraben is used in a single product.

How People Are Exposed to Parabens:

People can be exposed to parabens through touching, swallowing, or eating products that contain parabens. Many products, such as makeup, moisturizers, hair-care products, and shaving creams, contain parabens. Parabens in these products are absorbed through the skin. Parabens also can enter the body when pharmaceuticals, foods, and drinks containing parabens are swallowed or eaten. Parabens that enter the body are quickly excreted.

How Parabens Affect People’s Health:

Human health effects from environmental exposure to low levels of parabens are unknown. In 2006, the industry-led Cosmetic Ingredient Review (CIR), in a partnership with the U.S. Food and Drug Administration (FDA), determined that there was no need to change CIR’s original conclusion from 1984 that parabens are safe for use in cosmetics. The FDA allows single or multiple parabens to be added to food or food packaging as antimicrobials to prevent food spoilage.

Levels of Parabens in the U.S. Population:

Centers for Disease Control and Prevention scientists measured parabens in the urine of more than 2,548 participants aged six years and older who took part in the National Health and Nutrition Examination Survey (NHANES) during 2005–2006. By measuring these chemicals in urine, scientists can estimate the amount of parabens that has entered people’s bodies.

CDC scientists found Methylparaben and propylparaben in the urine of most of the people tested, indicating widespread exposure to these parabens in the U.S. population.

In adults younger than age 60, non-Hispanic blacks had higher levels of methyl paraben than non-Hispanic whites.

Females had several-fold higher concentrations of methylparaben and propylparabens than males, which likely reflect the greater use of products containing parabens.

Finding a measurable amount of parabens in urine does not imply that they cause an adverse health effect. Biomonitoring studies on levels of parabens provide physicians and public health officials with reference values so that they can determine whether people have been exposed to higher levels of parabens than are found in the general population. Biomonitoring data can also help scientists plan and conduct research on exposure and health effects.

References:

Chen J, et al. Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicol Applied Pharmacol, 2007; 221:278–284.

Oishi, S. Effects of propyl paraben on the male reproductive system. Food Chem Toxicol, 2002; 40:1807–1813.

Referenced links:

https://www.cdc.gov/biomonitoring/parabens_factsheet.html

Parabens IgG+IgA
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