Pancreatic Polypeptide: A Key Marker for Pancreatic Health and Endocrine Function
Pancreatic Polypeptide (PP) is a 36-amino acid hormone secreted by the F-cells in the pancreas, playing an essential role in regulating digestive functions, pancreatic secretion, and appetite. As a critical component of the pancreas's endocrine system, it is involved in controlling pancreatic enzyme release and influencing gastrointestinal motility.
Pancreatic Polypeptide is produced by specialized cells in the pancreas, known as F-cells, which are located in the islets of Langerhans. It is released into the bloodstream in response to various physiological conditions such as food intake, digestion, and changes in the body's energy balance. PP helps regulate the release of pancreatic enzymes and bicarbonate, which are vital for proper digestion. It also plays a role in reducing appetite and influencing the motility of the gastrointestinal tract.
Measurement of Pancreatic Polypeptide levels is important in diagnosing and monitoring a range of conditions related to pancreatic health, particularly those affecting the pancreas's endocrine and exocrine functions. Elevated levels of PP are often associated with:
Pancreatic Neuroendocrine Tumors (PanNETs): Increased levels of PP can be indicative of pancreatic endocrine tumors, particularly in conditions like multiple endocrine neoplasia type 1 (MEN1).
Pancreatitis: During acute pancreatitis, PP levels may rise initially but can decrease as the condition progresses. Chronic pancreatitis can lead to impaired secretion of PP.
Diabetes: Altered PP levels may contribute to metabolic dysfunction and impaired glucose regulation, especially in chronic pancreatic conditions.
PP plays a significant role in regulating the pancreas's exocrine function by inhibiting the secretion of digestive enzymes and bicarbonate. It also influences the motility of the gastrointestinal tract, helping maintain the body's digestive processes. As a result, abnormalities in PP levels can serve as valuable biomarkers for detecting pancreatic dysfunction and disorders such as pancreatitis and pancreatic cancer.
A Pancreatic Polypeptide test is typically used when there's a need to investigate pancreatic function, particularly in conditions like neuroendocrine tumors or pancreatitis. The test can help determine whether elevated or decreased levels of PP correlate with the presence of underlying pancreatic diseases. Normal PP levels typically range between 40–80 pmol/L, though values may vary depending on individual health factors.
Pancreatic Polypeptide is a vital hormone that provides insight into the overall health and function of the pancreas. By measuring PP levels, healthcare providers can diagnose and monitor conditions such as pancreatic neuroendocrine tumors, pancreatitis, and metabolic disorders like diabetes. Its role in regulating pancreatic and gastrointestinal functions makes it an essential marker for maintaining proper digestive health.
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Decreased levels of Pancreatic Polypeptide (PP) can indicate several conditions related to pancreatic dysfunction, particularly those affecting the pancreas's endocrine and exocrine functions. Here are some potential causes and conditions associated with low PP levels:
In chronic pancreatitis, which is long-term inflammation of the pancreas, the ability of the pancreas to secrete hormones and digestive enzymes can be impaired. Low levels of PP can occur due to damage to the pancreatic cells responsible for its production.
Exocrine pancreatic insufficiency (EPI) occurs when the pancreas cannot produce enough digestive enzymes. This condition may also lead to a decrease in pancreatic polypeptide production, as the pancreas struggles to perform its necessary functions effectively.
In individuals with diabetes, especially when related to pancreatic dysfunction (such as in type 1 or advanced type 2 diabetes), pancreatic polypeptide secretion may be reduced due to damage to the pancreatic cells involved in hormone production.
After surgical removal of a portion of the pancreas, such as in cases of pancreatic cancer or severe pancreatitis, there may be a reduction in PP secretion because the number of F-cells (the cells that produce PP) is decreased.
As pancreatic polypeptide has a role in regulating digestive enzymes and gastrointestinal motility, decreased levels may also reflect disturbances in the overall functioning of the digestive system.
In summary, low pancreatic polypeptide levels may signal underlying pancreatic damage or dysfunction. It’s important for healthcare providers to evaluate PP levels in the context of clinical symptoms and other diagnostic tests to accurately assess pancreatic health.
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Easily upload lab results from any provider, whether it's a hospital, independent lab, or home testing service. We support PDFs, scanned documents, and JPEGs from patient portals. No need to log in to multiple platforms — everything is centralized in one secure space.
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Our database covers over 10,000 biomarkers with clear, simple explanations—so you can finally understand your results and what to do next.
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Enter Your Lab Reports — Always Free
If you'd like to handle inputting your health data into your account, you can do so with our easy-to-use data entry forms. Our user-friendly form is designed to guide you through the quick and easy submission process, making it simple to keep track of your health metrics. This is available to both Complete plan and Unlimited plan members.
Our user-friendly form guides you through a quick, simple submission process, making it easy to enter your health metrics.
Add your results anytime with our easy entry form. It's quick, guided, and helps you stay organized — free for all members.
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View your lab data through easy-to-read graphs and tables. Quickly spot patterns, track changes, and compare results across different dates — all without digging through multiple reports. You can also select and compare graphs of specific biomarkers side-by-side to better understand how they relate and change over time.
See your lab reports in clear graphs and tables. Spot patterns, track changes, and compare results over time — all in one place.
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Export Your Complete Lab History
After collecting lab results from different providers, you can download your entire history combined into a single file. Choose from PDF, Excel, or CSV formats to easily review, share, or get a second opinion—no more juggling multiple reports.
After collecting lab results from different providers, you can download your entire history combined into a single file.
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Data Entry Service for Your Reports
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest. Complete plan members receive one report entered for free, then $15 per report after that. Unlimited plan members receive ten report entries for free, then $15 per report after that.
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest.
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Whether you're working with a doctor, nutritionist, caregiver, or wellness coach, you can securely share your complete lab history by sending an invite link to anyone you trust. You have full control over who sees your information and for how long, ensuring your privacy and peace of mind at every step.
Share your full lab history with your doctor, nutritionist, or coach using a secure invite link.
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I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
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Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
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If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
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There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our Data Entry Service is for when you don't want to manually type in your lab results yourself. You simply upload your report (PDF, image, or screenshot), and our trained team enters the information into your Healthmatters account for you — accurately and neatly organized, ready to view in graphs, tables, and timelines.
The $15 per report covers the time and care it takes for a real person to review your file, make sure each result is entered correctly, and double-check for accuracy. This ensures your health data is precise and easy to work with — without you having to spend the time doing it yourself.
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All professional accounts allow you to import and onboard an unlimited number of clients and their lab results. The distinction between professional plans lies solely in the data entry service.
The Pro Monthly Plus plan is priced at $75 per month and includes a data entry service for five reports each month. Additional reports can be self-entered at no extra cost or, if preferred, you can use our data entry service for an additional fee of $15 per report.
The Pro Monthly plan is priced at $45 per month and does not include a data entry service. Self-entry is free for an unlimited number of reports, and you can opt for the data entry service at a fee of $15 per report.
You also have the option to upgrade to higher monthly or to annual plans, which come with substantial discounts. All upgrades can be done directly from your account.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
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Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional account is designed for health professionals who wish to track and organize their clients' laboratory results.
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Optimal Result:
26.1 - 518.1 pg/mL.