Oleic 18:1 n9

Optimal Result: 14 - 21 wt %.

3200 Metabolomix+ - FMV Urine Genova Diagnostics

From Healthmatters.io Team

Lab Results Explained and Tracked

Oleic acid (OA) has an 18-carbon backbone with one double bond at the 9th position (18:1n9). Oleic acid’s main dietary source is olive oil, and it is also available as a supplement. OA can also be synthesized in the body by adding a double bond to stearic acid using the enzyme delta-9-desaturase. Oleic acid is important in cell membrane fluidity and has attracted a lot of positive attention due the amount of olive oil found in the ‘Mediterranean diet.’ OA’s antiinflammatory and immunomodulatory effects have been extensively studied and found to be beneficial in many conditions such as cancer, neurodegenerative disorders, inflammation, autoimmunity, cardiovascular disease, diabetes, wound healing, and infection. There is also literature to suggest that OA may be a selective biomarker of isolated impaired glucose tolerance regardless of fasting glucose. OA can lower blood lipids- mainly total cholesterol, LDL-cholesterol, and triglycerides. It also dampens the inflammatory response within the vascular endothelium.

References:

- Carrillo Pérez C, Cavia Camarero MdM, Alonso de la Torre S. Antitumor effect of oleic acid; mechanisms of action. A review. Nutrición Hospitalaria, 2012, v 27, n 6 (NoviembreDiciembre), p 1860-1865. 2012.

- Sales-Campos H, Reis de Souza P, Crema Peghini B, Santana da Silva J, Ribeiro Cardoso C. An overview of the modulatory effects of oleic acid in health and disease. Mini reviews in medicinal chemistry. 2013;13(2):201-210.

- Parthasarathy S, Khoo JC, Miller E, Barnett J, Witztum JL, Steinberg D. Low density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis. Proceedings of the National Academy of Sciences. 1990;87(10):3894-3898.

- Llor X, Pons E, Roca A, et al. The effects of fish oil, olive oil, oleic acid and linoleic acid on colorectal neoplastic processes. Clinical Nutrition. 2003;22(1):71-79.

- Massaro M, De RC. Vasculoprotective effects of oleic acid: epidemiological background and direct vascular antiatherogenic properties. Nutrition, metabolism, and cardiovascular diseases: NMCD. 2002;12(1):42-51.

- Cardoso C, Favoreto Jr S, Oliveira L, et al. Oleic acid modulation of the immune response in wound healing: a new approach for skin repair. Immunobiology. 2011;216(3):409-415.

- Cobb J, Eckhart A, Motsinger-Reif A, Carr B, Groop L, Ferrannini E. α-Hydroxybutyric acid is a selective metabolite biomarker of impaired glucose tolerance. Diabetes Care. 2016;39(6):988-995.

- Lopez-Huertas E. Health effects of oleic acid and long chain omega-3 fatty acids (EPA and DHA) enriched milks. A review of intervention studies. Pharmacological research. 2010;61(3):200-207.

- Carluccio MA, Massaro M, Bonfrate C, et al. Oleic Acid Inhibits Endothelial Activation. Arteriosclerosis, thrombosis, and vascular biology. 1999;19(2):220-228.

- Urpi-Sarda M, Casas R, Chiva-Blanch G, et al. Virgin olive oil and nuts as key foods of the Mediterranean diet effects on inflammatory biomakers related to atherosclerosis. Pharmacol Res. 2012;65(6):577-583.

- Yary T, Voutilainen S, Tuomainen T-P, Ruusunen A, Nurmi T, Virtanen JK. Serum n–6 polyunsaturated fatty acids, Δ5- and Δ6-desaturase activities, and risk of incident type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. The American journal of clinical nutrition. 2016;103(5):1337-1343.

- Lee JM, Lee H, Kang S, Park WJ. Fatty Acid Desaturases, Polyunsaturated Fatty Acid Regulation, and Biotechnological Advances. Nutrients. 2016;8(1).

Lab Results Explained and Tracked

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What does it mean if your Oleic 18:1 n9 result is too high?

Elevations can be seen in diets high in olive oil, nuts, and seeds – or in patients supplementing with OA. In general, higher levels are beneficial and no adverse clinical associations are seen.

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What does it mean if your Oleic 18:1 n9 result is too low?

Decreased dietary intake of OA-rich foods, (olive/ safflower/sunflower oils) will lower levels. Because stearic acid is its precursor, low levels of stearic acid may result in low OA. Lack of vitamin and mineral cofactors for delta9-desaturase, or a SNP in the enzyme, may result in lower production of oleic acid.

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Oleic 18:1 n9

All Your Lab Results. One Simple Dashboard.

What does it mean if your Oleic 18:1 n9 result is too high?

All Your Lab Results. One Simple Dashboard.

Import, Track, and Share Your Lab Results Easily

Import, Track, and Share Your Lab Results

What does it mean if your Oleic 18:1 n9 result is too low?

Article Review & Sources

Bring All Your Lab Results Together — In One Place

Gather Your Lab History — and Finally Make Sense of It

Finally, Your Lab Results Organized and Clear

Advanced Plan

Unlimited Account

Pro Monthly

What's included in a Healthmatters membership

Import Lab Results from Any Source

See Your Health Timeline

Understand What Your Results Mean

Enter Your Lab Reports Yourself — Always Free Enter Your Lab Reports — Always Free

Visualize Your Results

Export Your Complete Lab History in a Single File Export Your Complete Lab History

Comprehensive Data Entry Service for Your Reports Data Entry Service for Your Reports

Securely Share With Anyone You Trust

Let Your Lab Results Tell the Full Story

Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.

Bring all your results together to compare, track progress, export your history, and share securely.

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All Your Lab Results.
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