Molybdenum

Optimal result: 15 – 175 ug/g creat

The potential for Molybdenum toxicity is low and may be associated with aching joints, gout-like symptoms, hyperuricosuria, elevated blood Molybdenum, hallucinations and seizures.

Molybdenum deficiency is quite rare and a case report shows an acquired deficiency due to long-term parenteral nutrition.

Sources of Molybdenum:

- Beans (lima, white, red, green, pinto, peas),

- grains (wheat, oat, rice),

- nuts,

- vegetables (asparagus, dark leafy, Brassicas),

- milk, cheese.

Absorption factors:

- Molybdenum absorption is passive in the intestines.

- Urinary excretion is a direct reflection of dietary Molybdenum intake, not necessarily Molybdenum status.

- Increased Mo intake may elevate urinary copper excretion.

Sources of Molybdenum:

- Beans (lima, white, red, green, pinto, peas),

- grains (wheat, oat, rice),

- nuts,

- vegetables (asparagus, dark leafy, Brassicas),

- milk, cheese.

Absorption factors:

- Molybdenum absorption is passive in the intestines.

- Urinary excretion is a direct reflection of dietary Molybdenum intake, not necessarily Molybdenum status.

- Increased Mo intake may elevate urinary copper excretion.

Biochemical Actions:

Four enzymes require Molybdenum as a cofactor: sulfite oxidase, xanthine oxidase, aldehyde oxidase and mitochondrial amidoxime-reducing component (mARC).

These enzymes are important in detoxification. Sulfite oxidase converts sulfite to sulfate.

Molybdenum has been used clinically to treat Wilson’s disease to bind copper and prevent absorption.

Because ofthe copper-chelating property, Molybdenum has been studied as an anti-tumortherapy as well as its ability to inhibit profibrotic and proinflammatory cytokines for the treatment of arthritis and MS.

References:

Institute of Medicine Panel on M. In: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC): National Academies Press (US) Copyright 2001 by the National Academy of Sciences. All rights reserved.; 2001.

Novotny JA, Peterson CA. Molybdenum. Adv Nutr. 2018;9(3):272-273.

Molybdenum
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