Linoleic acid (LA) is the only essential omega-6 fatty acid and must be obtained from the diet. From LA, other omega-6s can be created using elongase and desaturase enzymes. LA contains 18 carbons, with 2 double bonds, the first of which is at the 6th carbon position (18:2n6). LA is found in nuts and vegetable oils (corn, soybean, canola, sunflower, etc.) as well as most meats. When the double bonds of LA are arranged differently, the term conjugated LA (CLA) is used. Although technically CLA can be termed a trans-fat, a natural type of CLA can be obtained in the dietary intake of meat and milk from ruminant animals. There are many isomers of CLA – some beneficial and others are not as well defined. There is some controversy regarding how much LA is needed from the diet for adequacy. Although LA is needed to synthesize downstream fatty acids, it may lead to increased inflammatory fatty acid production. Several studies show that LA lowers blood cholesterol levels and improves all-cause mortality However, their current role in atherosclerosis and cardiometabolic disease are being revisited. There is difficulty in differentiating the biological effects of LA from arachidonic acid in health and disease. In fact, it has been shown that LA is the most abundant fatty acid found in LDL and is one of the first fatty acids to oxidize. Studies are showing that LA promotes oxidative stress, oxidized LDL, and may be a major dietary cause of cardiovascular disease, especially when consumed via industrial vegetable oils.
References:
- Whelan J, Fritsche K. Linoleic Acid. Advances in Nutrition. 2013;4(3):311-312.
- Subbaiah PV, Sircar D, Aizezi B, Mintzer E. Differential effects of conjugated linoleic acid isomers on the biophysical and biochemical properties of model membranes. Biochimica et biophysica acta. 2010;1798(3):506-514.
- Jandacek RJ. Linoleic acid: a nutritional quandary. Paper presented at: Healthcare2017
- Salas-Salvado J, Marquez-Sandoval F, Bullo M. Conjugated Linoleic Acid Intake In Humans: A Systematic Review Focusing on Its Effect on Body Composition, Glucose, and Lipid Metabolism. Critical Reviews in Food Science and Nutrition. 2006;46(6):479-488.
- Li J, Guasch-Ferre M, Li Y, Hu FB. Dietary intake and biomarkers of linoleic acid and mortality: systematic review and meta-analysis of prospective cohort studies. The American journal of clinical nutrition. 2020.
- Hegazy M, Elsayed NM, Ali HM, Hassan HG, Rashed L. Diabetes Mellitus, Nonalcoholic Fatty Liver Disease, and Conjugated Linoleic Acid (Omega 6): What Is the Link? Journal of Diabetes Research. 2019;2019:5267025.
- Smedman A, Vessby B. Conjugated linoleic acid supplementation in humans--metabolic effects. Lipids. 2001;36(8):773-781.
- DiNicolantonio JJ, O Keefe JH. Omega-6 vegetable oils as a driver of coronary heart disease: the oxidized linoleic acid hypothesis. Open Heart. 2018;5(2):e000898.
- Burns JL, Nakamura MT, Ma DW. Differentiating the biological effects of linoleic acid from arachidonic acid in health and disease. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2018;135:1-4.
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Elevations are seen with high dietary fat intake (especially vegetable oils), or with supplementation of CLA. The delta-6-desaturase enzyme converts LA to downstream fatty acids. Lack of vitamin and mineral cofactors, or a SNP in the enzyme may slow its ability to covert and elevate LA levels. Additionally, there is competition with the omega-3 fatty acids for use of this enzyme which may contribute to elevated levels depending on availability. High levels of LA are associated with obesity, inflammatory conditions such as IBD, various cancers, cardiovascular disease, altered cognition, and brain development.
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Linoleic acid deficiency is rare, especially give current dietary trends which include excess vegetable oils. However, lack or decreased intake of foods containing LA can contribute to lower levels. Additionally, a SNP in delta-6-desaturase may potentially alter the enzyme function and promote downstream metabolism. Essential linoleic acid deficiencies have been mainly associated with skin conditions and impaired growth and development. Low levels of LA may contribute to impaired wound healing since it has been found to modulate a cellular response in wound healing by increasing the migration and functions of inflammatory and endothelial cells, and by inducing angiogenesis at the wound site.
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I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
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What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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AA/EPA, Akkermansia muciniphila, Alloprevotella, Alpha Gliadin IgG, Alpha-Beta Gliadin IgG, Amylase/Protease Inhibitors IgG, Anti-Actin IgG, Anti-LPS (IgG + IgM), Anti-LPS IgA, Anti-Zonulin IgG, Arachidonic acid (AA), Bacillus coagulans, Bacteroides, Bifidobacterium bifidum, Bifidobacterium infantis, Bifidobacterium lactis, Clostridium, Clotridiales Incertae Sedis IV, Copper to Zinc Ratio, Eggerthella lenta, Escherichia coli Nissle, Faecalibacterium, Farinins IgG, Gamma Gliadin IgG, Globulins IgG, Gluteomorphin IgG, HMW Glutenin IgG, Lactobacillus paracasei, Linoleic acid (LA), LMW Glutenin IgG, Omega Gliadin IgG, Oscillospira, Porphyromonas gingivalis, Prodynorphin IgG, Pseudobutyrivibrio, Purinin IgG, Serpin IgG, Streptococcus, Total Omega-6, Tyzzerella
