Klebsiella are gram-negative, facultative anaerobic, non-motile, rod-shaped bacteria. Array 12 assesses immune reactivity to Klebsiella pneumoniae, Klebsiella oxytoca and Klebsiella pneumoniae uti. Klebsiella is one of the common hospital-acquired pathogens. The cross-reactivity between Klebsiella and collagen in the uvea, may explain its involvement in uvetits and iritis. The mechanism of molecular mimicry could be applied to ankylosing spondylitis, rheumatoid arthritis and Crohn’s disease, after infection with causative microbes. After gut mucosal activation by Klebsiella antigens and production of secretory anti-Klebsiella antibodies, repeated Klebsiella infections in the large intestine of susceptible individuals could lead to increased levels of Klebsiella IgG antibodies in the blood. When these IgG anti-Klebsiella antibodies reach a certain limit, they will activate the complement cascade and complement components, plus other factors causing tissue injury leading to autoimmune reactivity.
Klebsiella
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