Interleukin 13 is a mediator of allergic inflammation and different diseases including asthma.
Interleukin 13 is implicated in numerous processes, including a) recruitment of eosinophils and M2 macrophages to the lung, b) induction of mucus secretion into the airways and goblet cell metaplasia, c) proliferation of smooth muscle cells, and d) fibrosis via fibroblast activation and subsequent collagen deposition.
References:
- Ingram JL, Kraft M (2012). "IL-13 in asthma and allergic disease: asthma phenotypes and targeted therapies". The Journal of Allergy and Clinical Immunology. 130 (4): 829–42, quiz 843–4. doi:10.1016/j.jaci.2012.06.034. PMID 229510
- https://insight.jci.org/articles/view/150107
Interleukin 13, Serum
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