Interleukin-10 is an important suppressor of immune responses.
In vitro studies indicate that Interleukin-10 directly inhibits IL-2 and IL-5 production by TH1 and TH2 cells. Interleukin-10 acts as an immunosuppressor of antigen presenting cells (APC). Interleukin-10 suppresses epidermal Langerhans cell APC function, monocyte chemokines expression, and the bactericidal responses of macrophages. A number of studies suggest that IL-10 plays a role in controlling inflammation, autoimmunity, and angiogenesis.
References:
- Ding UZ, Fu S, Zamarin D, et al. Interleukin-10. In: Thomson AW, Lotze MT eds. Cytokine Handbook. 4th ed, vol 1. London, UK, and San Diego, Calif: Academic Press, Elsevier Science;2003:603-625.
- Mosser DM, Zhang X. Interleukin-10: New perspectives on an old cytokine. Immunol Rev. 2008 Dec; 226:205-218. PubMed 19161426
- Hedrich CM, Bream JH. Cell type-specific regulation of IL-10 expression In inflammation and disease. Immunol Res. 2010 Jul; 47(1-3):185-206. PubMed 20087682
- Iyer SS, Cheng G. Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Crit Rev Immunol. 2012;32(1):23-63. doi:10.1615/critrevimmunol.v32.i1.30
Interleukin 10, Serum
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