Insulin is a hormone produced by the beta cells of the pancreas that helps move glucose (sugar) from the bloodstream into your cells for energy and storage. When insulin is working well, your body can keep blood sugar in a healthy range with relatively small amounts of insulin. When insulin is not working well (insulin resistance), the pancreas often compensates by producing more insulin, which can lead to elevated insulin levels even before blood sugar becomes abnormal.
Insulin, Intact (LC/MS/MS) specifically measures intact insulin molecules using liquid chromatography–tandem mass spectrometry. Compared to many immunoassays, LC/MS/MS can provide higher analytical specificity and may be less affected by cross-reactivity from insulin precursors or breakdown products. This makes it a useful option when insulin results need to be as accurate and reliable as possible.
This test is often ordered in these situations:
Metabolic health evaluation (insulin resistance, prediabetes risk, metabolic syndrome)
Investigation of high fasting insulin with normal glucose
Unexplained low blood sugar symptoms (possible hyperinsulinemia)
Clarifying insulin status when results from other methods appear inconsistent
Monitoring metabolic improvements over time (weight loss, exercise, medication changes)
How to interpret an elevated Insulin, Intact (LC/MS/MS) result
A high intact insulin level most commonly suggests that your pancreas is producing extra insulin to compensate for insulin resistance. This can happen even when fasting glucose and HbA1c are still in the “normal” range, making insulin an early marker of metabolic stress.
Common patterns associated with elevated intact insulin include:
Insulin resistance (often linked to abdominal weight gain, inactivity, genetics, or PCOS)
Prediabetes risk (especially if fasting glucose is trending upward)
Metabolic syndrome (often alongside high triglycerides, low HDL, high blood pressure)
Fatty liver risk (non-alcoholic fatty liver disease is strongly associated with insulin resistance)
Reactive hypoglycemia symptoms (insulin spikes after meals may cause a “crash” later)
Symptoms that can sometimes occur with high insulin or insulin resistance include:
Increased hunger or cravings, especially for carbohydrates
Energy crashes after meals
Difficulty losing weight
Brain fog or fatigue
Darkened skin patches (acanthosis nigricans) in some individuals
In women: irregular cycles or acne/hair changes (possible PCOS pattern)
If insulin is elevated, it is often helpful to review related markers, such as:
Fasting glucose
HbA1c
Oral glucose tolerance test (OGTT), sometimes with insulin measurements
C-peptide (helps confirm how much insulin your body is producing)
Triglycerides and HDL cholesterol
ALT/AST (liver enzymes)
Waist circumference and blood pressure
hsCRP (inflammation often overlaps with metabolic dysfunction)
How to interpret a decreased Insulin, Intact (LC/MS/MS) result
Low intact insulin can be normal in some healthy individuals, especially those who are very insulin sensitive, physically active, or following a lower-carbohydrate diet. However, insulin that is unexpectedly low may also reflect reduced insulin production.
Potential causes of low intact insulin include:
Very high insulin sensitivity (often paired with low-normal fasting glucose)
Prolonged fasting or very low carbohydrate intake
Pancreatic beta-cell dysfunction (possible progression toward diabetes in some cases)
Type 1 diabetes or autoimmune beta-cell loss (typically with high glucose and low C-peptide)
Advanced type 2 diabetes (when the pancreas can no longer keep up)
Certain medications or conditions that reduce insulin secretion
Symptoms that may be seen when insulin production is too low (especially if glucose is high) include:
Increased thirst and urination
Unintentional weight loss
Fatigue
Blurry vision
Frequent infections or slow wound healing
If insulin is low and glucose is high, C-peptide is one of the most important follow-up tests to help determine whether your body is producing enough insulin.
What to do if your Insulin, Intact (LC/MS/MS) is abnormal
If elevated:
Consider pairing this result with fasting glucose, HbA1c, and triglycerides/HDL to assess insulin resistance risk
Focus on lifestyle strategies that improve insulin sensitivity, such as:
Resistance training 2–4 times per week
Regular walking or aerobic activity after meals
Higher-fiber meals and reduced ultra-processed carbohydrates
Prioritizing protein at meals
Improving sleep quality and stress management
Discuss with your clinician whether additional testing (OGTT with insulin, C-peptide) makes sense
If clinically appropriate, medications like metformin or GLP-1 therapies may be considered depending on your overall metabolic profile
If decreased:
Check whether fasting glucose is also low (which may be normal) or high (which may be concerning)
Consider C-peptide to confirm insulin production
If symptoms of hypoglycemia or hyperglycemia are present, follow up promptly with a clinician
If diabetes is suspected, additional testing may include autoantibodies (GAD65, IA-2, ZnT8) and ketone evaluation
Important notes about testing conditions
Insulin levels can vary significantly based on:
Whether you were truly fasting (typically 8–12 hours)
Recent carbohydrate intake the day before
Stress, illness, inflammation, or poor sleep
Steroid medications or other drugs affecting glucose metabolism
Timing and handling of the sample
For the most meaningful trend tracking, it helps to test under similar conditions each time.
A high Insulin, Intact (LC/MS/MS) result most often means your pancreas is producing more insulin than expected to keep your blood sugar in a normal range. This pattern is commonly seen with insulin resistance, where your cells don’t respond to insulin as efficiently, so your body compensates by making extra insulin. In many people, elevated insulin is an early warning sign that metabolic health is under strain, even if fasting glucose and HbA1c still look “normal.” Over time, consistently high insulin levels can be associated with increased fat storage (especially around the abdomen), stronger hunger and carbohydrate cravings, energy crashes after meals, and difficulty losing weight.
Because this test measures intact insulin using LC/MS/MS, it is considered a more specific way to assess true circulating insulin, with less risk of interference from insulin-related fragments that can affect some other testing methods. That makes it particularly useful for tracking trends over time and for identifying early metabolic changes.
If your intact insulin is high, it’s helpful to interpret it alongside other markers such as fasting glucose, HbA1c, triglycerides, HDL cholesterol, and C-peptide. A high insulin level together with high-normal glucose, rising HbA1c, elevated triglycerides, or low HDL can strengthen the case for insulin resistance and increased risk for prediabetes and type 2 diabetes. Some people may also experience symptoms such as fatigue after meals, brain fog, increased appetite, or shakiness if insulin spikes lead to reactive low blood sugar later on.
The good news is that elevated insulin is often modifiable. Many people can lower insulin levels and improve insulin sensitivity through targeted lifestyle changes such as strength training, regular movement (especially walking after meals), improving sleep, reducing ultra-processed carbohydrates, increasing fiber and protein at meals, and managing stress. If levels are significantly elevated or trending upward, your clinician may recommend additional testing (such as an oral glucose tolerance test with insulin measurements) or discuss medication options depending on your overall risk profile and goals.
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Every lab result is automatically organized on a chronological timeline, giving you a complete picture of your health journey.
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Whether it's a blood test, GI panel, urinalysis, or something else, lab reports measure numerous biomarkers that reveal what's happening inside your body. Our extensive database covers over 10,000 biomarkers, providing clear, simple explanations of what each result means and how you can take action—no matter your membership level. Say goodbye to confusion and get the insights you need to better understand your health.
Our database covers over 10,000 biomarkers with clear, simple explanations—so you can finally understand your results and what to do next.
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Enter Your Lab Reports — Always Free
If you'd like to handle inputting your health data into your account, you can do so with our easy-to-use data entry forms. Our user-friendly form is designed to guide you through the quick and easy submission process, making it simple to keep track of your health metrics. This is available to both Complete plan and Unlimited plan members.
Our user-friendly form guides you through a quick, simple submission process, making it easy to enter your health metrics.
Add your results anytime with our easy entry form. It's quick, guided, and helps you stay organized — free for all members.
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View your lab data through easy-to-read graphs and tables. Quickly spot patterns, track changes, and compare results across different dates — all without digging through multiple reports. You can also select and compare graphs of specific biomarkers side-by-side to better understand how they relate and change over time.
See your lab reports in clear graphs and tables. Spot patterns, track changes, and compare results over time — all in one place.
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Export Your Complete Lab History
After collecting lab results from different providers, you can download your entire history combined into a single file. Choose from PDF, Excel, or CSV formats to easily review, share, or get a second opinion—no more juggling multiple reports.
After collecting lab results from different providers, you can download your entire history combined into a single file.
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Data Entry Service for Your Reports
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest. Complete plan members receive one report entered for free, then $15 per report after that. Unlimited plan members receive ten report entries for free, then $15 per report after that.
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest.
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Whether you're working with a doctor, nutritionist, caregiver, or wellness coach, you can securely share your complete lab history by sending an invite link to anyone you trust. You have full control over who sees your information and for how long, ensuring your privacy and peace of mind at every step.
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I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
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As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
With a Healthmatters account, you can:
Professionals can also analyze client data more efficiently and save time managing lab reports.
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you're on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
The Complete Plan ($15/month) is perfect for individuals who want ongoing access to their health data. It includes unlimited lab imports, visual tracking, custom ranges, result explanations, full account exports, and secure sharing — all with a simple monthly subscription. You can cancel anytime and restart your plan whenever you're ready — your data will still be there waiting for you. You can also upgrade to the Unlimited Plan at any time, with the cost prorated based on what you've already paid.
The Unlimited Plan ($250 one-time) is also designed for individuals but offers lifetime access with no ongoing subscription. You'll get all the same features as the Complete Plan, plus a larger initial data entry allowance (10 reports), making it a great choice if you prefer a one-time payment and long-term use without monthly fees.
In short:
There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our Data Entry Service is for when you don't want to manually type in your lab results yourself. You simply upload your report (PDF, image, or screenshot), and our trained team enters the information into your Healthmatters account for you — accurately and neatly organized, ready to view in graphs, tables, and timelines.
The $15 per report covers the time and care it takes for a real person to review your file, make sure each result is entered correctly, and double-check for accuracy. This ensures your health data is precise and easy to work with — without you having to spend the time doing it yourself.
Prefer to do it yourself? You can always use our free self-entry tool to add results manually — it just takes a bit more time and attention.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
All professional accounts allow you to import and onboard an unlimited number of clients and their lab results. The distinction between professional plans lies solely in the data entry service.
The Pro Monthly Plus plan is priced at $75 per month and includes a data entry service for five reports each month. Additional reports can be self-entered at no extra cost or, if preferred, you can use our data entry service for an additional fee of $15 per report.
The Pro Monthly plan is priced at $45 per month and does not include a data entry service. Self-entry is free for an unlimited number of reports, and you can opt for the data entry service at a fee of $15 per report.
You also have the option to upgrade to higher monthly or to annual plans, which come with substantial discounts. All upgrades can be done directly from your account.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewExplore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Yes, you can download your information anytime. We offer two easy ways to export your lab data:
This makes it simple to save, back up, or share your health data whenever you need.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
Optimal Result:
0 - 16 uIU/ml.