INFLAMMATION
Inflammation/ Immunology:
Biomarkers:
- Calprotectin is a marker of neutrophil-driven inflammation. Produced in abundance at sites of inflammation, this biomarker has been proven clinically useful in differentiating between Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS). [1,2]
- Eosinophil Protein X is a marker of eosinophil-driven inflammation and allergic response.
- Fecal Secretory IgA is a marker of gut secretory immunity and barrier function.
- Fecal Occult Blood Test detects hidden blood; fecal immunochemical testing (FIT) has been recommended by the American College of Gastroenterology as the preferred noninvasive test for colorectal cancer screening/detection.
Inflammation/ Immunology Score:
Inflammation and immunology in the gastrointestinal tract are intricately linked, with biomarkers providing valuable insights into underlying conditions. Calprotectin, a calcium-binding protein released during intestinal inflammation, aids in distinguishing between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), guiding treatment decisions. Elevated levels of eosinophil protein X (EPX) signal eosinophil activation, indicating immune-mediated conditions like IBD, parasitic infections, or food allergies. Meanwhile, fecal secretory IgA (sIgA), the primary antibody in the gut, serves as a frontline defense against pathogens and toxins. Elevated sIgA levels suggest compromised intestinal barrier function or conditions like celiac disease or colon cancer, while low levels may indicate systemic IgA deficiency or severe inflammatory bowel disease. These biomarkers collectively provide a comprehensive understanding of inflammation and immune responses in the gut, facilitating targeted therapeutic interventions to restore gut health and alleviate associated symptoms.
Calprotectin: Calprotectin, a calcium-binding protein with antimicrobial properties, serves as a reliable marker for intestinal inflammation. It is released into the stool from the intestinal mucosa during inflammatory processes. Calprotectin levels are stable in feces and remain unaffected by dietary substances. Elevated levels are associated with conditions like inflammatory bowel disease (IBD), colorectal cancer, infections, and NSAID use. Differentiating between IBD and irritable bowel syndrome (IBS) is aided by fecal calprotectin testing, with higher levels indicating potential IBD. Therapeutic strategies for elevated calprotectin include addressing underlying causes such as infection or chronic NSAID use.
Eosinophil Protein X (EPX): EPX, also known as eosinophil-derived neurotoxin (EDN), is a marker of eosinophil activation and inflammation, particularly in the gastrointestinal tract. Elevated EPX levels are associated with immune-mediated conditions like IBD, certain parasitic infections, and food allergies. Inflammatory bowel disorders such as microscopic colitis and eosinophilic gastrointestinal disorders may also elevate EPX. Therapeutic considerations involve targeting underlying causes such as allergies, IBD, or parasitic infections.
Fecal Secretory IgA: Secretory IgA (sIgA), the predominant antibody in the intestinal lumen, plays a vital role in protecting the gut epithelium from pathogens and toxins. Elevated levels of fecal sIgA may indicate defective epithelial barrier function, celiac disease, colon cancer, infections, or IBS. Therapeutic approaches involve addressing factors contributing to immune upregulation and inflammation, such as infections, compromised intestinal barrier function, or heightened response to noninfectious stimuli. Conversely, low levels of fecal sIgA may be associated with systemic IgA deficiency or severe/prolonged inflammatory bowel disease (IBD), necessitating a comprehensive assessment and consideration of the patient's medical condition.
These biomarkers provide valuable insights into inflammation and immune responses in the gastrointestinal tract, aiding in the diagnosis, monitoring, and management of various gastrointestinal disorders. Therapeutic interventions targeted at underlying causes can help restore gut health and alleviate symptoms associated with inflammation.
Score explanation:
The functional imbalance scores are generated using weighted algorithms that incorporate biomarkers belonging to each functional category.
0 to 2: This represents a low need for support.
2 to 3: This represents an optional need for support.
4 to 6: This represents moderate need for support.
7 to 10: This represents high need for support.
Therapeutic Support Options:
Therapeutic support options are static to serve as potential treatment ideas. Clinician discretion is advised when selecting appropriate therapeutics for individual patients.
- Elimination Diet/ Food Sensitivity Testing
- Mucosa Support: Slippery Elm, Althea, Aloe, DGL, etc.
- Zinc Carnosine
- L-Glutamine
- Quercetin
- Turmeric
- Omega-3's
What does it mean if your INFLAMMATION result is too high?
Score explanation:
The functional imbalance scores are generated using weighted algorithms that incorporate biomarkers belonging to each functional category.
0 to 2: This represents a low need for support.
2 to 3: This represents an optional need for support.
4 to 6: This represents moderate need for support.
7 to 10: This represents high need for support.
Therapeutic Support Options:
Therapeutic support options are static to serve as potential treatment ideas. Clinician discretion is advised when selecting appropriate therapeutics for individual patients.
- Elimination Diet/ Food Sensitivity Testing
- Mucosa Support: Slippery Elm, Althea, Aloe, DGL, etc.
- Zinc Carnosine
- L-Glutamine
- Quercetin
- Turmeric
- Omega-3's
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