IgG LFA Antigen + CK10
The IgG LFA Antigen + CK10 test evaluates long-term antibody responses to both Borrelia antigens (using a lateral flow assay, or LFA) and Cytokeratin 10 (CK10), a structural protein found in epithelial tissues such as the skin. This combined test helps clinicians explore the connection between infection-driven immune responses and autoimmune reactivity.
What IgG LFA Antigen + CK10 Means
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IgG antibodies usually appear weeks after infection and remain detectable long-term as part of immune memory.
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A positive IgG LFA antigen result suggests past exposure to Borrelia or related tick-borne pathogens.
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The detection of IgG antibodies against CK10 may point toward autoimmune activity involving epithelial tissues, which can sometimes develop after infection-triggered immune responses.
Clinical Importance
This test may be most useful in patients who have:
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Chronic or unexplained skin symptoms such as rashes, blistering, or inflammatory dermatoses
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Persistent immune symptoms following a suspected tick-borne infection
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Overlap of infection and autoimmunity, where Borrelia exposure may have triggered autoimmune processes
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Complex or long-standing multi-system symptoms that are difficult to classify with single-marker tests
Patient Takeaway
A positive IgG LFA Antigen + CK10 result indicates that your immune system has previously recognized Borrelia antigens and may also be reacting to CK10, a self-protein in epithelial tissues. This combination can provide important clues about both past infection and possible autoimmune involvement.
Your healthcare provider will interpret the result in the context of your symptoms, medical history, and additional laboratory findings.
If your test is reported as equivocal (borderline), antibody levels are close to the cutoff and not clearly positive or negative. In this case, repeat or confirmatory testing is usually recommended.
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