IgG B. burgdorferi AG
The IgG Borrelia burgdorferi Antigen (Ag) test measures long-term antibodies against antigens of Borrelia burgdorferi, the main bacterium responsible for Lyme disease, particularly in North America. Unlike species-specific tests that focus on one strain, antigen-based assays detect immune responses to a broader range of Borrelia proteins, offering insight into both past exposure and potential later-stage infection.
What IgG B. burgdorferi Ag Means
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IgG antibodies appear weeks to months after infection and may remain present for years, even after treatment.
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A positive result suggests that your immune system has mounted a previous response to Borrelia antigens, which can be a clue in cases of chronic or late-stage Lyme disease.
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Because antigens cover multiple Borrelia proteins, this test may capture antibody responses that complement other markers such as OspC, OspA, or VlsE.
Clinical Importance
Testing for IgG Borrelia burgdorferi Ag can be helpful in patients who have:
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Persistent Lyme symptoms such as joint pain, neurological issues, or fatigue
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Evidence of late-stage disease, including Lyme arthritis or neuroborreliosis
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A history of tick exposure in Lyme-endemic areas where infection risk is high
Patient Takeaway
A positive IgG B. burgdorferi Ag test means your immune system has recognized antigens from the Lyme disease bacterium. This does not always indicate an active infection, since IgG antibodies may persist long after the original illness.
Your healthcare provider will interpret the result together with your symptoms, clinical history, and other Lyme disease markers to build a complete diagnostic picture.
If your result is equivocal (borderline), antibody levels are near the cutoff and the finding is uncertain. In these cases, repeat or confirmatory testing is often recommended.
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