Heat shock protein 60 (HSP60) is a mitochondrial chaperonin that plays a role in the transportation and refolding of proteins from the cytoplasm into the mitochondrial matrix. HSP60’s amino acid sequence bears a similarity to its homolog in plants, bacteria, and humans. Chlamydia is an obligate intracellular bacterium. Chlamydia HSP60 (C.Hsp60) is associated with the outer membrane complexes of Chlamydia and appears to be responsible for proinflammatory pathologic manifestations. Autoimmune disease can be induced by specific antigens such as HSPs, since antibodies against bacterial HSPs can cross-react with human HSP60 and induce cytotoxic damage to the stressed endothelial cells.
Human + Chlamydia HSP-60
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