Homogentisic acid (HGA) is an intermediate in the breakdown (catabolism) of the amino acids tyrosine and phenylalanine. In healthy metabolism, the enzyme homogentisate 1,2-dioxygenase (HGD) converts HGA to the next step in the pathway, so only trace or undetectable amounts appear in urine. Labs measure HGA in a spot urine sample and report it normalized to creatinine (mmol HGA per mol creatinine) to account for urine concentration.
Why it matters
-
Markedly elevated HGA is a hallmark of alkaptonuria, a rare inherited (autosomal recessive) condition caused by variants in the HGD gene. When HGD activity is low or absent, HGA builds up and is excreted in large amounts. Over years, oxidized HGA can deposit in tissues (ochronosis), contributing to early spine and large-joint osteoarthritis, tendon/ligament issues, heart-valve calcification, and a higher risk of kidney or prostate stones.
-
Normal/undetectable HGA is expected in most people and supports intact tyrosine metabolism.
How to read your result (always use your lab’s reference range)
-
Normal / Undetectable: Typical finding; no evidence of excess HGA. No specific action is needed unless symptoms or other organic acids suggest a metabolic issue.
-
Elevated:
-
Borderline/near-cutoff: Consider repeat testing on a well-collected first-morning urine to confirm and review pre-analytic factors (hydration, collection, transport).
-
Clearly/markedly high: Strongly consider alkaptonuria. Your clinician may order targeted quantitative HGA testing, evaluate for clinical signs (e.g., urine darkening on standing, early joint disease), and discuss HGD genetic testing. Diagnosis is not based on one value alone; confirmation is standard.
-
Symptoms and clinical clues that prompt follow-up
-
Infants/children: Diapers or urine that darken on standing or with alkali; later, joint stiffness.
-
Adults: Early-onset back or large-joint pain, reduced spine flexibility, tendon/ligament problems, bluish-black cartilage discoloration (ears), and history of renal/prostate stones.
What can influence the result
-
Hydration/collection: The creatinine ratio helps, but extremely dilute or concentrated urine can still shift values. Follow collection and shipping instructions closely.
-
Diet/supplements: Typical dietary tyrosine/phenylalanine does not raise HGA above reference range when HGD function is normal.
-
Medications/therapies: Nitisinone (used selectively in alkaptonuria) dramatically lowers urinary HGA; it can raise blood tyrosine, so it requires medical supervision and dietary oversight. Always tell the lab and your clinician about current therapies.
What to do next (actionable steps)
-
Normal/undetectable HGA: No HGA-specific action needed. Interpret alongside symptoms and the rest of the Organic Acids panel.
-
Borderline elevation:
-
Repeat the test (first-morning urine, proper handling).
-
Review collection, medications, supplements.
-
Discuss whether quantitative HGA and/or genetic counseling/testing is appropriate based on history and family background.
-
-
Clearly elevated:
-
Consult a clinician experienced in inherited metabolic conditions.
-
Consider confirmatory urine/plasma HGA and HGD genetic testing.
-
Management is individualized; it may include specialist follow-up for joints/spine/heart, physical therapy and pain strategies, and—in appropriate cases—nitisinone under specialist care.
-
Support joint health with healthy body weight, muscle strengthening, and low-impact exercise as tolerated.
-
Key takeaways
-
What it is: A urine marker of the tyrosine/phenylalanine pathway, reported as mmol/mol creatinine.
-
Normal result: Typical in most people.
-
High result: Think alkaptonuria—confirm with repeat/quantitative testing and consider HGD genetics.
-
Carrier detection: Routine urine HGA is not a dependable carrier screen.
-
Vitamin C: Not proven harmful in alkaptonuria; potential antioxidant role is uncertain—use only within a clinician-guided plan.
FAQs
Does one high result diagnose alkaptonuria?
No. It’s a strong clue, but clinicians confirm with repeat/quantitative HGA and usually HGD genetic testing.
Can food alone cause high HGA?
Not in people with normal HGD enzyme function. Marked elevations generally reflect enzyme deficiency, not diet.
My urine sometimes looks dark—do I have alkaptonuria?
Many factors can darken urine. The classic sign is urine that darkens on standing, plus a high HGA result. Testing clarifies.
Should my family get tested?
Because alkaptonuria is autosomal recessive, consider genetic counseling if someone in the family is diagnosed.
What does it mean if your Homogentisic acid result is too high?
An elevated homogentisic acid (HGA) result means more HGA is leaving your body in urine than expected. HGA is a byproduct of breaking down the amino acids tyrosine and phenylalanine. In most people, an enzyme called homogentisate 1,2-dioxygenase (HGD) keeps HGA extremely low. When HGA is clearly high, it raises concern for alkaptonuria, a rare inherited condition caused by changes in the HGD gene. Over time, excess HGA can deposit in tissues (called ochronosis), which is linked to early spine/large-joint arthritis, tendon/ligament problems, heart-valve calcification, and a higher risk of kidney or prostate stones.
How high is “high”?
Always compare your value to your lab’s reference range and units (mmol/mol creatinine).
-
Borderline/slightly above range: Can reflect collection issues, hydration, or normal biological variation. Recheck before drawing conclusions.
-
Markedly elevated: Much more suggestive of alkaptonuria and warrants targeted follow-up.
Symptoms and clues that strengthen suspicion
-
Urine that darkens on standing (or diapers that darken),
-
Early-onset back or large-joint pain, reduced flexibility,
-
Bluish-black discoloration of cartilage (e.g., ears),
-
Personal or family history of kidney/prostate stones.
Common misconceptions (good to know)
-
Carriers (one HGD variant) usually have normal HGA. A mild elevation is not a reliable way to identify carrier status; genetic testing is the right tool if carrier screening is needed.
-
Vitamin C doesn’t “worsen” alkaptonuria. It’s been discussed historically as an antioxidant with uncertain clinical benefit. If you’re prone to kidney stones, avoid high-dose supplements unless your clinician advises otherwise.
What to do next
-
Repeat to confirm if the elevation is borderline (ideally a first-morning urine, following the lab’s instructions).
-
If still elevated, ask your clinician about quantitative urine/plasma HGA and HGD genetic testing to confirm or rule out alkaptonuria.
-
If alkaptonuria is confirmed or strongly suspected:
-
Discuss care with a specialist familiar with inherited metabolic conditions.
-
Management may include nitisinone in selected cases (this typically dramatically lowers urinary HGA and requires monitoring of blood tyrosine and diet).
-
Joint protection: maintain a healthy weight, use low-impact exercise, and consider physical therapy.
-
Hydration and routine follow-up for stone risk and cardiac/orthopedic health.
-
What else to check
-
Review the rest of your Organic Acids panel and any amino acid testing for context.
-
Tell your provider about medications/supplements (including any prior or current nitisinone therapy).
-
Confirm proper collection/transport; extreme dilution or concentration can nudge results even when creatinine-corrected.
Key takeaways
-
Elevated HGA primarily points to impaired tyrosine metabolism; marked elevations strongly suggest alkaptonuria.
-
Confirm with repeat and targeted testing; consider genetic testing.
-
Treatment and monitoring are personalized; early recognition helps protect joints, kidneys, and heart over time.
All Your Lab Results.
One Simple Dashboard.
Import, Track, and Share Your Lab Results Easily
Import, Track, and Share Your Lab Results
Import lab results from multiple providers, track changes over time, customize your reference ranges, and get clear explanations for each result. Everything is stored securely, exportable in one organized file, and shareable with your doctor—or anyone you choose.
Cancel or upgrade anytime
Laboratories
Bring All Your Lab Results Together — In One Place
We accept reports from any lab, so you can easily collect and organize all your health information in one secure spot.
Pricing Table
Gather Your Lab History — and Finally Make Sense of It
Finally, Your Lab Results Organized and Clear
Personal plans
$79/ year
Advanced Plan
Access your lab reports, explanations, and tracking tools.
- Import lab results from any provider
- Track all results with visual tools
- Customize your reference ranges
- Export your full lab history anytime
- Share results securely with anyone
- Receive 5 reports entered for you
- Cancel or upgrade anytime
$250/ once
Unlimited Account
Pay once, access everything—no monthly fees, no limits.
- Import lab results from any provider
- Track all results with visual tools
- Customize your reference ranges
- Export your full lab history anytime
- Share results securely with anyone
- Receive 10 reports entered for you
- No subscriptions. No extra fees.
$45/ month
Pro Monthly
Designed for professionals managing their clients' lab reports
- Import lab results from any provider
- Track lab results for multiple clients
- Customize reference ranges per client
- Export lab histories and reports
- Begin with first report entered by us
- Cancel or upgrade anytime
About membership
What's included in a Healthmatters membership
Import Lab Results from Any Source
See Your Health Timeline
Understand What Your Results Mean
Visualize Your Results
Data Entry Service for Your Reports
Securely Share With Anyone You Trust
Let Your Lab Results Tell the Full Story
Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.
Bring all your results together to compare, track progress, export your history, and share securely.
What Healthmatters Members Are Saying
Frequently asked questions
Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
- Individuals who want to track and understand their health over time.
- Health professionals, such as doctors, nutritionists, and wellness coaches, need to manage and interpret lab data for their clients.
With a Healthmatters account, you can:
- Upload lab reports from any lab
- View your data in interactive graphs, tables, and timelines
- Track trends and monitor changes over time
- Customize your reference ranges
- Export and share your full lab history
- Access your results anytime, from any device
Professionals can also analyze client data more efficiently and save time managing lab reports.
Healthmatters.io personal account provides in-depth research on 10000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
- The GI Effects® Comprehensive Stool Profile,
- GI-MAP,
- The NutrEval FMV®,
- The ION Profile,
- Amino Acids Profile,
- Dried Urine Test for Comprehensive Hormones (DUTCH),
- Organic Acids Test,
- Organix Comprehensive Profile,
- Toxic Metals,
- Complete Blood Count (CBC),
- Metabolic panel,
- Thyroid panel,
- Lipid Panel,
- Urinalysis,
- And many, many more.
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
We implement proven measures to keep your data safe.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.