Glutathione (GSH) is a tripeptide (λ-glutamyl-cysteinylglycine) synthesized by most cells, serving as a critical marker of cellular health and resilience against toxic stress. In erythrocytes, GSH levels are a sensitive indicator of the body's intracellular GSH status and overall cellular well-being. It is the most abundant non-protein thiol in mammalian cells, playing key roles in various biological processes, such as detoxifying harmful compounds (xenobiotics), neutralizing reactive oxygen species, regulating cellular redox balance, and maintaining the oxidative state of vital protein sulfhydryl groups. Additionally, GSH supports immune function. Intracellular GSH concentrations are significantly higher than plasma levels, with plasma GSH largely derived from the liver. The active form, reduced GSH (rGSH), is maintained at a ratio of approximately 9:1 with its oxidized counterpart (GSSH) in healthy cells. However, once a blood sample is collected, erythrocyte rGSH is highly prone to oxidation, rapidly diminishing the rGSH ratio. Due to the impracticality of preventing ex vivo oxidation and the challenges of directly measuring rGSH in clinical settings, it is more feasible to assess total erythrocyte GSH as an indicator of overall GSH status. Research suggests that an unfavorable rGSHratio is closely associated with abnormally low total cellular GSH levels.
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What does it mean if your Glutathione; Erythrocytes result is too low?
Low GSH levels have been observed in a variety of conditions, including cardiovascular disease, cancer, AIDS, autism, alcoholism, neurodegenerative diseases like Alzheimer's and Parkinson's, and chronic exposure to toxic elements (such as mercury, lead, arsenic, cadmium, manganese, iron), as well as certain chemicals and drugs. In response to these challenges, cells may upregulate GSH synthesis as a protective measure. Factors that can elevate erythrocyte GSH levels include moderate alcohol intake, smoking, regular physical exercise, and acute exposure to toxic metals. Under these conditions, it is important to provide the body with the necessary nutrients to support GSH production. Magnesium and potassium are essential for the energy-dependent enzymatic steps in GSH synthesis, while cysteine is the rate-limiting amino acid.
Several nutritional products have been shown to boost erythrocyte GSH levels and enhance GSH biosynthesis, including high-quality whey protein, α-lipoic acid, curcumin, oral liposomal GSH, nebulized GSH, and, to a lesser extent, N-acetyl-L-cysteine. Supporting and maintaining healthy erythrocyte GSH levels is vital for cellular protection, overall health, and longevity, as well as for effective detoxification of toxic metals.
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Import Lab Results from Any Source
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Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
- Individuals who want to track and understand their health over time.
- Health professionals, such as doctors, nutritionists, and wellness coaches, need to manage and interpret lab data for their clients.
With a Healthmatters account, you can:
- Upload lab reports from any lab
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- Track trends and monitor changes over time
- Customize your reference ranges
- Export and share your full lab history
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Professionals can also analyze client data more efficiently and save time managing lab reports.
Healthmatters.io personal account provides in-depth research on 10000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
- The GI Effects® Comprehensive Stool Profile,
- GI-MAP,
- The NutrEval FMV®,
- The ION Profile,
- Amino Acids Profile,
- Dried Urine Test for Comprehensive Hormones (DUTCH),
- Organic Acids Test,
- Organix Comprehensive Profile,
- Toxic Metals,
- Complete Blood Count (CBC),
- Metabolic panel,
- Thyroid panel,
- Lipid Panel,
- Urinalysis,
- And many, many more.
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
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At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.