DYSBIOSIS
DYSBIOSIS
Biomarkers:
- IAD/Methane Score
- PP Bacteria/Yeast
- Reference Variance
- Total Abundance
Inflammation-Associated Dysbiosis (IAD) Score:
The Inflammation-Associated Dysbiosis score was developed from a pattern-based algorithm. When grouping patients according to their IAD scores, the group mean IAD score was negatively associated with commensal abundance and positively associated with fecal calprotectin, EPX, and sIgA. The score was validated in clinical studies including Genova’s database of IBD patients, and an independent UCLA study with a cohort of IBD patients.1 More information about the IAD score can be found in the publication: https://link.springer. com/article/10.1007/s10620-019-05828-8 It is unknown whether inflammation-associated dysbiosis is a cause and/or an effect of inflammation. A low IAD score with elevated inflammatory markers indicates the gut microbiome may not play a role in the inflammatory condition and other etiologies should be investigated (see zone 1 pattern description below). Longitudinal studies are needed to determine the significance of a high IAD score with normal inflammatory markers. It is possible that an inflammatory microbiome pattern may precede the rise of inflammatory markers.
Methane Dysbiosis Score (Immune Suppression):
The Methane Dysbiosis score was derived from an analysis of breath methane test results that correlated with certain markers on the GI Effects stool profile. Genova’ unpublished data found a unique correlation with markers indicating immune suppression (low fecal sIgA and EPX) and the presence of methanogens, potentially pathogenic bacteria, bacterial overgrowth, and certain parasitic organisms. (See zones 2 and 3 below for more information.) This dysbiosis pattern is associated with immune suppression and is distinct from the IAD pattern. It is unknown whether methane/methanogenic organisms are a cause and/or an effect of immune suppression. An elevated methane dysbiosis score may warrant treating potentially pathogenic organisms depending on the clinical picture. Additionally, intestinal barrier therapies may be helpful in supporting intestinal immune function.
Reference Variance Score:
The Reference Variance Score reflects the total number of an individual patient’s commensal bacteria (PCR) results that are out of reference range. This number ranges from zero to 12 and is denoted by the ‘x’ axis of the Commensal Balance infographic.
Score explanation:
The functional imbalance scores are generated using weighted algorithms that incorporate biomarkers belonging to each functional category.
0 to 2: This represents a low need for support.
2 to 3: This represents an optional need for support.
4 to 6: This represents moderate need for support.
7 to 10: This represents high need for support.
Therapeutic Support Options:
Therapeutic support options are static to serve as potential treatment ideas. Clinician discretion is advised when selecting appropriate therapeutics for individual patients.
- Pre-/Probiotics
- Increase Dietary Fiber Intake
- Consider SIBO Testing
- Increase Resistant Starches
- Increase Fermented Foods
- Meal Timing
What does it mean if your DYSBIOSIS result is too high?
Score explanation:
The functional imbalance scores are generated using weighted algorithms that incorporate biomarkers belonging to each functional category.
0 to 2: This represents a low need for support.
2 to 3: This represents an optional need for support.
4 to 6: This represents moderate need for support.
7 to 10: This represents high need for support.
Therapeutic Support Options:
Therapeutic support options are static to serve as potential treatment ideas. Clinician discretion is advised when selecting appropriate therapeutics for individual patients.
- Pre-/Probiotics
- Increase Dietary Fiber Intake
- Consider SIBO Testing
- Increase Resistant Starches
- Increase Fermented Foods
- Meal Timing
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