A urine creatinine concentration is part of every FMV analysis. All urinary biomarkers are ratioed to the creatinine concentration for standardization.
Urinary creatinine is commonly used as a laboratory standardization when evaluating urinary analytes. Creatinine excretion is influenced by muscle mass and body habitus since creatinine formation occurs in muscle. Dietary intake of proteins containing arginine and glycine (precursors of creatine) and creatine supplementation can elevate levels. Hydration status may also play a role in urinary creatinine levels.
References:
- Armstrong MD, Shaw K, Wall P. The phenolic acids of human urine. J Biol Chem. 1956;218:293.
- Cocker J, Mason HJ, Warren ND, Cotton RJ. Creatinine adjustment of biological monitoring results. Occup Med. 2011;61(5):349-353.
- Garde Ah, Hansen Åm, Kristiansen J, Knudsen Le. Comparison of Uncertainties Related to Standardization of Urine Samples with Volume and Creatinine Concentration. Ann Occup Hyg. 2004;48(2):171-179.
- Baxmann AC, Ahmed MS, Marques NC, et al. Influence of muscle mass and physical activity on serum and urinary creatinine and serum cystatin C. CJASN. 2008;3(2):348-354.
Creatinine Concentration (Amino Acids FMV)
Every lab result you’ve ever had, charted and explained.
Healthmatters is a tracker for your lab results. Upload a report from any lab, any country — every marker charted and explained.
Start with my report →
All our content is backed by peer-reviewed studies, academic research, and trusted medical sources. We’re committed to accuracy and transparency — see our editorial policy for details.