Collinsella is a genus of bacteria commonly found in the human gut and plays a role in breaking down carbohydrates and producing certain metabolites. While present in healthy individuals, Collinsella becomes clinically relevant when it grows in excess. Research shows that elevated Collinsella is associated with increased intestinal permeability, higher inflammatory markers, insulin resistance, metabolic syndrome, obesity, and cardiovascular risk factors.
High Collinsella abundance is also linked to reduced butyrate-producing bacteria and higher production of pro-inflammatory metabolites, which can weaken the gut barrier and contribute to systemic inflammation. Patients with rheumatoid arthritis and certain autoimmune conditions also tend to show elevated levels, suggesting a role in immune dysregulation.
Low levels are generally not concerning and may indicate a balanced microbiome or dietary patterns lower in fermentable carbohydrates.
On the Gut Zoomer panel, Collinsella helps identify patterns related to inflammation, metabolic health, carbohydrate fermentation, and gut barrier integrity, making it a meaningful marker for both digestive and whole-body health.
What does it mean if your Collinsella result is too high?
High levels of Collinsella may indicate:
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Increased intestinal permeability (leaky gut)
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Systemic inflammation
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Metabolic syndrome or insulin resistance
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Elevated cardiovascular risk markers
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Diet high in sugars and refined carbohydrates
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Dysbiosis with reduced butyrate producers
Potential Symptoms of Elevated Collinsella
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Bloating or gas
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Blood sugar fluctuations
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Fatigue after meals
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Digestive discomfort
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Inflammation-related symptoms (joint stiffness, mild aches)
Potential Treatment & Management Approaches
Evidence and clinical patterns suggest the following may help rebalance elevated Collinsella:
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Increase dietary fiber, especially from whole grains, legumes, vegetables
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Reduce refined carbohydrates and added sugars
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Increase foods that support butyrate producers (e.g., resistant starch, cooked/cooled potatoes, oats, green bananas)
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Probiotics targeting SCFA production (Bifidobacteria, certain Lactobacillus species)
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Anti-inflammatory dietary patterns, such as Mediterranean or high-polyphenol diets
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Address gut barrier support (L-glutamine, zinc carnosine, probiotics, soluble fiber)
If high Collinsella is accompanied by metabolic symptoms or elevated inflammatory markers, discussing the results with a healthcare provider is recommended.
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