C. difficile is the leading cause of antibiotic-associated nosocomial diarrhea and colitis in the industrialized world. This gram-positive bacterium can reside in the human host without triggering serious clinical conditions, however, when the colonized bacteria produce toxin A and toxin B, the resulting changes in gastrointestinal pH and cytoskeletal structures of the barrier, serious disorders can occur. Pathogenic C. difficile has been linked to colitis, irritable bowel disease and liver disorders.
Clostridium difficile
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