Cadmium

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Cadmium is a natural element found in tiny amounts in air, water, soil, and food. It is used in batteries, alloys for electroplating (auto industries), the production of pigments, and as stabilizers for polyvinyl plastic. Exposure to cadmium occurs primarily occurs via ingestion of foods grown in contaminated soil or by the inhalation of cigarette smoke. According to the Agency for Toxic Substances and Disease Registry, dermal absorption of cadmium is negligible. Cadmium toxicity generates reactive oxygen species, interferes with DNA repair, and binds the mitochondria affecting cell proliferation, differentiation, and apoptosis. Symptoms of cadmium toxicity include anemia, liver disease, vomiting, diarrhea, kidney disease, and impaired bone density. Long-term exposure to cadmium may lead to cancer and organ system toxicity such as skeletal, urinary, reproductive, cardiovascular, central and peripheral nervous, and respiratory systems.

SOURCES:

Found in food such as shellfish, leafy vegetables, rice, cereals, cocoa butter, dried seaweed, and legumes. Also present in nickel cadmium batteries, cigarette smoke (including second-hand smoke), insecticides, fertilizer, motor oil, emissions and exhaust. Drinking water, air, and occupational exposures are also seen.

NUTRIENT INTERACTIONS:

Iron deficiency is associated with higher cadmium burden and absorption of cadmium may increase during very early stages of iron deficiency. Zinc deficiency is associated with an increase in Cadmium, as a result of the antagonistic relationship between the elements.

Dietary cadmium inhibits GI absorption of calcium and interferes with calcium and vitamin D metabolism. Low dietary calcium stimulates synthesis of calcium- binding protein which enhances Cadmium absorption.

References:

- Yedjou CG, Patlolla AK, Sutton DJ. Heavy Metals Toxicity and the Environment Paul B Tchounwou. Published in final edited form as: EXS. 2012;3:133-164.

- Kordas K, Loonnerdal B, Stoltzfus RJ. Interactions between Nutrition and Environmental Exposures: Effects on Health Outcomes in Women and Children. J Nutr. 2007;137(12):2794-2797.

- Afridi HI, Kazi TG, Kazi NG, et al. Evaluation of cadmium, lead, nickel and zinc status in biological samples of smokers and nonsmokers hypertensive patients. J Hum Hypertens. 2010;24(1):34-43.

- ATSDR. Cadmium Toxicity Clinical Assessment - Laboratory Tests. Environmental Health and Medicine Education 2008; https://www.atsdr.cdc.gov/csem/csem.asp?csem=6&po=15 2020.

- Lauwerys R, Buchet J, Roels H. The relationship between cadmium exposure or body burden and the concentration of cadmium in blood and urine in man. Int Arch Occup Environ health. 1976;36(4):275-285.

- Adams SV, Newcomb PA. Cadmium blood and urine concentrations as measures of exposure: NHANES 1999-2010. J Expo Sci Environ Epidemiol. 2014;24(2):163-170.

- Goyer RA. Toxic and essential metal interactions. Ann Rev Nutr. 1997;17(1):37-50.

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PHYSIOLOGIC EFFECTS:

Cadmium accumulates in the liver and kidneys and has a long half-life (17-30 years). The renal and skeletal systems are the main targets of Cadmium toxicity. Urinary cadmium reflects integrated exposure over time and body burden. Urinary levels do not rise significantly after acute exposure. Elevated blood cadmium levels confirm recent acute exposure.

CLINICAL SIGNIFICANCE:

Renal tubular toxicity, decreased bone density with increased bone turnover and fractures.

Chronic inhalation exposure is associated with emphysema. Acute oral ingestion leads to abdominal pain, nausea, vomiting, muscle cramps, and GI tract erosions.

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Cadmium

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What does it mean if your Cadmium result is too high?

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Import, Track, and Share Your Lab Results

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Bring All Your Lab Results Together — In One Place

Gather Your Lab History — and Finally Make Sense of It

Finally, Your Lab Results Organized and Clear

Advanced Plan

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What's included in a Healthmatters membership

Import Lab Results from Any Source

See Your Health Timeline

Understand What Your Results Mean

Enter Your Lab Reports Yourself — Always Free Enter Your Lab Reports — Always Free

Visualize Your Results

Export Your Complete Lab History in a Single File Export Your Complete Lab History

Comprehensive Data Entry Service for Your Reports Data Entry Service for Your Reports

Securely Share With Anyone You Trust

Let Your Lab Results Tell the Full Story

Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.

Bring all your results together to compare, track progress, export your history, and share securely.

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All Your Lab Results.
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