Other names: Glutarylcarnit., C5DC
Optimal Result:
0 - 0.1 umol/L,
or
0 - 0.05 nmol/ML.
Glutarylcarnitine, also known as C5DC (C5-dicarboxylic), is a specific form of acylcarnitine that plays a key role in the metabolism of amino acids, particularly in the breakdown of lysine and tryptophan. It is part of the broader group of acylcarnitines, which are compounds that facilitate the transport of fatty acids and metabolites into the mitochondria, where they are oxidized to produce energy.
Glutarylcarnitine is measured in the Carnitine and Acylcarnitine panel (usually in µmol/L or nmol/mL), and its levels provide important information about the metabolic processes involving the breakdown of complex molecules. Abnormal levels of C5DC can point to specific metabolic disorders related to the breakdown of certain amino acids and fatty acids.
Normal Range: Typically varies by lab, but the reference range for C5DC is commonly low in healthy individuals. Any significant elevation outside the reference range can be clinically significant.
Elevated levels of Glutarylcarnitine, C5DC, are typically associated with disorders in the metabolism of lysine and tryptophan, most notably in conditions like Glutaric Aciduria Type 1. This rare genetic disorder leads to the accumulation of organic acids like glutaric acid and its derivatives, which includes C5DC. These elevated metabolites can be toxic, particularly to the brain, and can lead to neurological issues such as encephalopathy, developmental delays, and movement disorders.
Glutaric Aciduria Type 1 (GA-1): This inherited metabolic disorder results from a deficiency of the enzyme glutaryl-CoA dehydrogenase, which is essential for the breakdown of glutaryl-CoA, a product of lysine and tryptophan metabolism. As a result, intermediate metabolites like glutarylcarnitine accumulate in the bloodstream, and symptoms can range from acute neurological crises to chronic developmental issues.
Other Metabolic Disorders: Elevated levels of C5DC can also be seen in disorders related to fatty acid oxidation or other organic acidemias, although Glutaric Aciduria Type 1 is the most specific condition linked to this biomarker.
An abnormal elevation in C5DC, when combined with clinical symptoms or other abnormal findings in the Carnitine and Acylcarnitine panel, may prompt further diagnostic testing to confirm or rule out Glutaric Aciduria Type 1 or other metabolic conditions. Early detection is essential for managing the condition and preventing severe neurological damage, typically through dietary interventions and sometimes with specific medications to reduce metabolic load.
In summary, Glutarylcarnitine, C5DC is a significant marker in assessing the integrity of amino acid and fatty acid metabolism. Elevated levels warrant further investigation for potential metabolic disorders, particularly Glutaric Aciduria Type 1, and require careful clinical follow-up.
Elevated levels of Glutarylcarnitine (C5DC) in the blood often indicate a disruption in the metabolism of lysine and tryptophan, two essential amino acids. This biomarker is most commonly associated with Glutaric Aciduria Type 1 (GA-1), but other metabolic or physiological conditions can also contribute to its elevation. Below is a structured overview of possible causes and their clinical implications.
GA-1 is a rare autosomal recessive metabolic disorder caused by a deficiency in the enzyme glutaryl-CoA dehydrogenase. This enzyme plays a critical role in breaking down lysine, hydroxylysine, and tryptophan. A deficiency leads to the accumulation of toxic metabolites such as glutaric acid, 3-hydroxyglutaric acid, and C5DC.
The accumulation of these metabolites, particularly in the basal ganglia of the brain, results in neurotoxicity. This can lead to irreversible damage if untreated.
Neurological Symptoms: Developmental delays, dystonia, seizures, and motor skill deterioration are common. Acute crises are often triggered by febrile illnesses or fasting during early childhood.
Physical Signs: Macrocephaly and cortical atrophy may also be observed.
Elevated C5DC levels on newborn screening.
Urinary organic acid analysis showing increased glutaric acid and 3-hydroxyglutaric acid.
Confirmatory genetic testing for mutations in the GCDH gene.
Dietary Intervention: A low-lysine diet to reduce toxic metabolite production.
Supplements: Carnitine supplementation to prevent secondary carnitine deficiency.
Emergency Protocols: Preventing catabolic stress during illness.
These disorders result from defects in enzymes involved in amino acid metabolism, leading to elevated metabolites such as methylmalonic acid and propionylcarnitine. While C5DC may be elevated, it is not as specific to these conditions as it is to GA-1.
Symptoms include vomiting, lethargy, metabolic acidosis, and failure to thrive. Early diagnosis via acylcarnitine profiling is crucial.
Disorders affecting mitochondrial fatty acid breakdown can lead to elevated C5DC levels due to impaired energy production during fasting or illness. These conditions often present with hypoglycemia, muscle weakness, and metabolic crises.
Acute illnesses or fasting can temporarily elevate C5DC levels as the body mobilizes amino acids and fatty acids for energy production.
High-protein diets may also cause mild elevations.
These elevations are typically transient and resolve once the underlying stressor is addressed.
Impaired renal function can reduce the excretion of metabolites like C5DC, causing their accumulation in the blood. However, this is a less common cause compared to metabolic disorders.
Rare mitochondrial disorders or genetic defects affecting amino acid and fatty acid metabolism may also lead to elevated C5DC levels. These conditions can present with muscle weakness, fatigue, or developmental delays.
| Condition/Cause | Key Biomarkers | Symptoms | Management |
|---|---|---|---|
| Glutaric Aciduria Type 1 | Elevated C5DC, glutaric acid | Developmental delays, dystonia | Low-lysine diet, carnitine supplements |
| Methylmalonic/Propionic Acidemia | Methylmalonic acid, propionylcarnitine | Vomiting, lethargy | Protein restriction |
| Fatty Acid Oxidation Disorders | Long-chain acylcarnitines | Hypoglycemia, muscle weakness | Avoid fasting |
| Metabolic Stress | Transient C5DC rise | Resolves with recovery | Supportive care |
| Kidney Dysfunction | Elevated metabolites | Variable symptoms based on severity | Address underlying renal condition |
Elevated C5DC levels are most commonly associated with Glutaric Aciduria Type 1 but may also indicate other metabolic or physiological conditions. Early diagnosis through newborn screening and confirmatory tests is critical for timely intervention. Management strategies vary depending on the underlying cause but often involve dietary modifications and metabolic support measures to prevent complications such as neurological damage.
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Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
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If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you're on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
The Complete Plan ($15/month) is perfect for individuals who want ongoing access to their health data. It includes unlimited lab imports, visual tracking, custom ranges, result explanations, full account exports, and secure sharing — all with a simple monthly subscription. You can cancel anytime and restart your plan whenever you're ready — your data will still be there waiting for you. You can also upgrade to the Unlimited Plan at any time, with the cost prorated based on what you've already paid.
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There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our Data Entry Service is for when you don't want to manually type in your lab results yourself. You simply upload your report (PDF, image, or screenshot), and our trained team enters the information into your Healthmatters account for you — accurately and neatly organized, ready to view in graphs, tables, and timelines.
The $15 per report covers the time and care it takes for a real person to review your file, make sure each result is entered correctly, and double-check for accuracy. This ensures your health data is precise and easy to work with — without you having to spend the time doing it yourself.
Prefer to do it yourself? You can always use our free self-entry tool to add results manually — it just takes a bit more time and attention.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
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All professional accounts allow you to import and onboard an unlimited number of clients and their lab results. The distinction between professional plans lies solely in the data entry service.
The Pro Monthly Plus plan is priced at $75 per month and includes a data entry service for five reports each month. Additional reports can be self-entered at no extra cost or, if preferred, you can use our data entry service for an additional fee of $15 per report.
The Pro Monthly plan is priced at $45 per month and does not include a data entry service. Self-entry is free for an unlimited number of reports, and you can opt for the data entry service at a fee of $15 per report.
You also have the option to upgrade to higher monthly or to annual plans, which come with substantial discounts. All upgrades can be done directly from your account.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
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Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
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